Lineage-Selective Disturbance of Early Human Hematopoietic Progenitor Cell Differentiation by the Commonly Used Plasticizer Di-2-ethylhexyl Phthalate via Reactive Oxygen Species: Fatty Acid Oxidation Makes the Difference

Lineage-Selective Disturbance of Early Human Hematopoietic Progenitor Cell Differentiation by the Commonly Used Plasticizer Di-2-ethylhexyl Phthalate via Reactive Oxygen Species: Fatty Acid Oxidation Makes the Difference

Exposure to ubiquitous endocrine-disrupting chemicals (EDCs) is a major public health concern. We analyzed the physiological impact of the EDC, di-2-ethylhexyl phthalate (DEHP), and found that its metabolite, mono-2-ethylhexyl phthalate (MEHP), had significant adverse effects on myeloid hematopoiesi...

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Bibliographic Details
Main Authors: Lars Kaiser, Isabel Quint, René Csuk, Manfred Jung, Hans-Peter Deigner
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
endocrine-disrupting compounds
fatty acid oxidation
reactive oxygen species
ROS quenching
hematopoietic stem and progenitor cells
di-2-ethylhexyl phthalate
Online Access:https://www.mdpi.com/2073-4409/10/10/2703

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