Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans
Abstract To investigate the association between muscle fiber capillarization and indices of insulin sensitivity in healthy older adults. A skeletal muscle biopsy was taken from the m. vastus lateralis of 22 healthy (nondiabetic) male older adults. In addition, all participants underwent an Oral Gluc...
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| Format: | Article |
| Language: | English |
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Wiley
2017-05-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.13278 |
| _version_ | 1819229401327337472 |
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| author | Tim Snijders Joshua P. Nederveen Lex B. Verdijk Alfons J. H. M. Houben Gijs H. Goossens Gianna Parise Luc J. C. vanLoon |
| author_facet | Tim Snijders Joshua P. Nederveen Lex B. Verdijk Alfons J. H. M. Houben Gijs H. Goossens Gianna Parise Luc J. C. vanLoon |
| author_sort | Tim Snijders |
| collection | DOAJ |
| description | Abstract To investigate the association between muscle fiber capillarization and indices of insulin sensitivity in healthy older adults. A skeletal muscle biopsy was taken from the m. vastus lateralis of 22 healthy (nondiabetic) male older adults. In addition, all participants underwent an Oral Glucose Tolerance Test (OGTT). Muscle fiber capillarization was assessed by immunohistochemistry. Participants were divided into a group with relatively low (LOW) or high (HIGH) muscle fiber capillarization (capillary‐to‐fiber perimeter exchange (CFPE) index), based on the median value for the entire group. All participants were healthy, nonobese, and had a normal glucose tolerance, according to the individual OGTT results. Whereas no differences in blood glucose concentrations were observed between groups during the OGTT, the postprandial increase in plasma insulin concentrations was significantly greater in the LOW compared to the HIGH muscle fiber capillarization group (P < 0.05). Skeletal muscle fiber capillarization may determine insulin sensitivity in humans. |
| first_indexed | 2024-12-23T11:12:35Z |
| format | Article |
| id | doaj.art-cc185da194ea4a288005e489c7515547 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-12-23T11:12:35Z |
| publishDate | 2017-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-cc185da194ea4a288005e489c75155472022-12-21T17:49:18ZengWileyPhysiological Reports2051-817X2017-05-01510n/an/a10.14814/phy2.13278Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humansTim Snijders0Joshua P. Nederveen1Lex B. Verdijk2Alfons J. H. M. Houben3Gijs H. Goossens4Gianna Parise5Luc J. C. vanLoon6Department of Human Biology and Movement Sciences NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Medical Center+ Maastricht The NetherlandsDepartment of Kinesiology McMaster University Hamilton Ontario CanadaDepartment of Human Biology and Movement Sciences NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Medical Center+ Maastricht The NetherlandsDepartment of Internal Medicine CARIM School for Cardiovascular Diseases Maastricht University Medical Center+ Maastricht The NetherlandsDepartment of Human Biology and Movement Sciences NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Medical Center+ Maastricht The NetherlandsDepartment of Kinesiology McMaster University Hamilton Ontario CanadaDepartment of Human Biology and Movement Sciences NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Medical Center+ Maastricht The NetherlandsAbstract To investigate the association between muscle fiber capillarization and indices of insulin sensitivity in healthy older adults. A skeletal muscle biopsy was taken from the m. vastus lateralis of 22 healthy (nondiabetic) male older adults. In addition, all participants underwent an Oral Glucose Tolerance Test (OGTT). Muscle fiber capillarization was assessed by immunohistochemistry. Participants were divided into a group with relatively low (LOW) or high (HIGH) muscle fiber capillarization (capillary‐to‐fiber perimeter exchange (CFPE) index), based on the median value for the entire group. All participants were healthy, nonobese, and had a normal glucose tolerance, according to the individual OGTT results. Whereas no differences in blood glucose concentrations were observed between groups during the OGTT, the postprandial increase in plasma insulin concentrations was significantly greater in the LOW compared to the HIGH muscle fiber capillarization group (P < 0.05). Skeletal muscle fiber capillarization may determine insulin sensitivity in humans.https://doi.org/10.14814/phy2.13278Agingoral glucose toleranceskeletal muscle |
| spellingShingle | Tim Snijders Joshua P. Nederveen Lex B. Verdijk Alfons J. H. M. Houben Gijs H. Goossens Gianna Parise Luc J. C. vanLoon Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans Physiological Reports Aging oral glucose tolerance skeletal muscle |
| title | Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans |
| title_full | Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans |
| title_fullStr | Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans |
| title_full_unstemmed | Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans |
| title_short | Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans |
| title_sort | muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans |
| topic | Aging oral glucose tolerance skeletal muscle |
| url | https://doi.org/10.14814/phy2.13278 |
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