Typhoidal Salmonella human challenge studies: ethical and practical challenges and considerations for low-resource settings

Typhoidal Salmonella human challenge studies: ethical and practical challenges and considerations for low-resource settings

Abstract Typhoidal Salmonella is a major global problem affecting more than 12 million people annually. Controlled human infection models (CHIMs) in high-resource settings have had an important role in accelerating the development of conjugate vaccines against Salmonella Typhi. The typhoidal Salmone...

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Bibliographic Details
Main Authors: Meriel Raymond, Malick M. Gibani, Nicholas P. J. Day, Phaik Yeong Cheah
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Trials
Subjects:
Research ethics
Controlled human infection models
Low-resource settings
Typhoidal Salmonella
Online Access:https://doi.org/10.1186/s13063-019-3844-z

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