TA-MSCs, TA-MSCs-EVs, MIF: their crosstalk in immunosuppressive tumor microenvironment
Abstract As an important component of the immunosuppressive tumor microenvironment (TME), it has been established that mesenchymal stem cells (MSCs) promote the progression of tumor cells. MSCs can directly promote the proliferation, migration, and invasion of tumor cells via cytokines and chemokine...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-022-03528-y |
| _version_ | 1828759631662415872 |
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| author | Zhenghou Zhang Xiangyu Zhou Jinshuai Guo Fusheng Zhang Yiping Qian Guang Wang Meiqi Duan Yutian Wang Haiying Zhao Zhi Yang Zunpeng Liu Xiaofeng Jiang |
| author_facet | Zhenghou Zhang Xiangyu Zhou Jinshuai Guo Fusheng Zhang Yiping Qian Guang Wang Meiqi Duan Yutian Wang Haiying Zhao Zhi Yang Zunpeng Liu Xiaofeng Jiang |
| author_sort | Zhenghou Zhang |
| collection | DOAJ |
| description | Abstract As an important component of the immunosuppressive tumor microenvironment (TME), it has been established that mesenchymal stem cells (MSCs) promote the progression of tumor cells. MSCs can directly promote the proliferation, migration, and invasion of tumor cells via cytokines and chemokines, as well as promote tumor progression by regulating the functions of anti-tumor immune and immunosuppressive cells. MSCs-derived extracellular vesicles (MSCs-EVs) contain part of the plasma membrane and signaling factors from MSCs; therefore, they display similar effects on tumors in the immunosuppressive TME. The tumor-promoting role of macrophage migration inhibitory factor (MIF) in the immunosuppressive TME has also been revealed. Interestingly, MIF exerts similar effects to those of MSCs in the immunosuppressive TME. In this review, we summarized the main effects and related mechanisms of tumor-associated MSCs (TA-MSCs), TA-MSCs-EVs, and MIF on tumors, and described their relationships. On this basis, we hypothesized that TA-MSCs-EVs, the MIF axis, and TA-MSCs form a positive feedback loop with tumor cells, influencing the occurrence and development of tumors. The functions of these three factors in the TME may undergo dynamic changes with tumor growth and continuously affect tumor development. This provides a new idea for the targeted treatment of tumors with EVs carrying MIF inhibitors. |
| first_indexed | 2024-12-11T01:01:11Z |
| format | Article |
| id | doaj.art-cc1ac325bc044228ab93e54afb02ea10 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-11T01:01:11Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-cc1ac325bc044228ab93e54afb02ea102022-12-22T01:26:20ZengBMCJournal of Translational Medicine1479-58762022-07-0120112310.1186/s12967-022-03528-yTA-MSCs, TA-MSCs-EVs, MIF: their crosstalk in immunosuppressive tumor microenvironmentZhenghou Zhang0Xiangyu Zhou1Jinshuai Guo2Fusheng Zhang3Yiping Qian4Guang Wang5Meiqi Duan6Yutian Wang7Haiying Zhao8Zhi Yang9Zunpeng Liu10Xiaofeng Jiang11Department of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityAbstract As an important component of the immunosuppressive tumor microenvironment (TME), it has been established that mesenchymal stem cells (MSCs) promote the progression of tumor cells. MSCs can directly promote the proliferation, migration, and invasion of tumor cells via cytokines and chemokines, as well as promote tumor progression by regulating the functions of anti-tumor immune and immunosuppressive cells. MSCs-derived extracellular vesicles (MSCs-EVs) contain part of the plasma membrane and signaling factors from MSCs; therefore, they display similar effects on tumors in the immunosuppressive TME. The tumor-promoting role of macrophage migration inhibitory factor (MIF) in the immunosuppressive TME has also been revealed. Interestingly, MIF exerts similar effects to those of MSCs in the immunosuppressive TME. In this review, we summarized the main effects and related mechanisms of tumor-associated MSCs (TA-MSCs), TA-MSCs-EVs, and MIF on tumors, and described their relationships. On this basis, we hypothesized that TA-MSCs-EVs, the MIF axis, and TA-MSCs form a positive feedback loop with tumor cells, influencing the occurrence and development of tumors. The functions of these three factors in the TME may undergo dynamic changes with tumor growth and continuously affect tumor development. This provides a new idea for the targeted treatment of tumors with EVs carrying MIF inhibitors.https://doi.org/10.1186/s12967-022-03528-yImmunosuppressive tumor microenvironmentTA-MSCsExtracellular vesiclesMacrophage migration inhibitory factorAnti-tumor immune cellsImmunosuppressive cells |
| spellingShingle | Zhenghou Zhang Xiangyu Zhou Jinshuai Guo Fusheng Zhang Yiping Qian Guang Wang Meiqi Duan Yutian Wang Haiying Zhao Zhi Yang Zunpeng Liu Xiaofeng Jiang TA-MSCs, TA-MSCs-EVs, MIF: their crosstalk in immunosuppressive tumor microenvironment Journal of Translational Medicine Immunosuppressive tumor microenvironment TA-MSCs Extracellular vesicles Macrophage migration inhibitory factor Anti-tumor immune cells Immunosuppressive cells |
| title | TA-MSCs, TA-MSCs-EVs, MIF: their crosstalk in immunosuppressive tumor microenvironment |
| title_full | TA-MSCs, TA-MSCs-EVs, MIF: their crosstalk in immunosuppressive tumor microenvironment |
| title_fullStr | TA-MSCs, TA-MSCs-EVs, MIF: their crosstalk in immunosuppressive tumor microenvironment |
| title_full_unstemmed | TA-MSCs, TA-MSCs-EVs, MIF: their crosstalk in immunosuppressive tumor microenvironment |
| title_short | TA-MSCs, TA-MSCs-EVs, MIF: their crosstalk in immunosuppressive tumor microenvironment |
| title_sort | ta mscs ta mscs evs mif their crosstalk in immunosuppressive tumor microenvironment |
| topic | Immunosuppressive tumor microenvironment TA-MSCs Extracellular vesicles Macrophage migration inhibitory factor Anti-tumor immune cells Immunosuppressive cells |
| url | https://doi.org/10.1186/s12967-022-03528-y |
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