Differences between finger and toe Meissner corpuscles: Searching for the optimal place to analyze meissner corpuscles in cutaneous biopsy
Background: Skin biopsy is a minimally invasive and repeatable technique, applicable in any part of the body that can allows for diagnosis and control of treatments, but to analyze Meissner corpuscles biopsy of glabrous skin is necessary it is recommendable obtained the maximal amount it is possible...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-03-01
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| Series: | Translational Research in Anatomy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214854X23000031 |
| _version_ | 1827963162307067904 |
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| author | Patricia Cuendias Rebeca del Rio Olivia García-Suárez Ramón Cobo Marialuisa Aragona Jorge Feito Benjamín Martín-Biedma José A. Vega Yolanda García-Mesa |
| author_facet | Patricia Cuendias Rebeca del Rio Olivia García-Suárez Ramón Cobo Marialuisa Aragona Jorge Feito Benjamín Martín-Biedma José A. Vega Yolanda García-Mesa |
| author_sort | Patricia Cuendias |
| collection | DOAJ |
| description | Background: Skin biopsy is a minimally invasive and repeatable technique, applicable in any part of the body that can allows for diagnosis and control of treatments, but to analyze Meissner corpuscles biopsy of glabrous skin is necessary it is recommendable obtained the maximal amount it is possible. Changes in density, size, and morphology occurs in several peripheral neuropathies as well as diseases affecting the central nervous system. Methods: We used immunohistochemistry and image analysis to establish differences in the immunohistochemical profile, density, morphology, size and depth relative to the epidermis of Meissner's corpuscles from fingers and toes in a homogeneous age-group. Results: The morphology of Meissner corpuscles was variable. In fingers ellipsoidal non-lobulated corpuscles predominate (about 82%) while in toes most of them showed irregular morphology (60%). No differences between fingers and toes were noted in the basic immunohistochemical profile, except for capsulation. The mean density of Meissner corpuscles was 3,22 ± 0,86/mm2 and 1,15 ± 0,71/mm2, respectively; and the Meissner corpuscles index was 1,09 ± 0,07 and 0,28 ± 0,09, respectively. Regarding the size Meissner corpuscles from the fingers measured 108 ± 24.2 μm x 64 ± 9 μm, and those from toes 87 ± 21.2 μm x 34 ± 6 μm. Finally, the depth relative to the epidermis was 3.6 ± 0.9 μm in fingers and 19 ± 16.2 μm in toes. Conclusion: the study of Meissner corpuscles in cutaneous biopsy from fingers may offer advantages over that from toes because in fingers Meissner's corpuscles are more abundant and superficial, larger, and express more regularly the defining markers of the main corpuscular components. |
| first_indexed | 2024-04-09T16:54:05Z |
| format | Article |
| id | doaj.art-cc1dcdfe36354f759e67e032c515ab35 |
| institution | Directory Open Access Journal |
| issn | 2214-854X |
| language | English |
| last_indexed | 2024-04-09T16:54:05Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Research in Anatomy |
| spelling | doaj.art-cc1dcdfe36354f759e67e032c515ab352023-04-21T06:45:21ZengElsevierTranslational Research in Anatomy2214-854X2023-03-0130100234Differences between finger and toe Meissner corpuscles: Searching for the optimal place to analyze meissner corpuscles in cutaneous biopsyPatricia Cuendias0Rebeca del Rio1Olivia García-Suárez2Ramón Cobo3Marialuisa Aragona4Jorge Feito5Benjamín Martín-Biedma6José A. Vega7Yolanda García-Mesa8Grupo SINPOS, Departamento de Morfología y Biología Celular, Universidad de Oviedo, SpainGrupo SINPOS, Departamento de Morfología y Biología Celular, Universidad de Oviedo, SpainGrupo SINPOS, Departamento de Morfología y Biología Celular, Universidad de Oviedo, SpainGrupo SINPOS, Departamento de Morfología y Biología Celular, Universidad de Oviedo, SpainDipartimento di Scienze Veterinarie, Università di Messina, Messina, ItalyGrupo SINPOS, Departamento de Morfología y Biología Celular, Universidad de Oviedo, Spain; Servicio de Anatomía Patológica, Complejo Asistencial Universitario de Salamanca, Salamanca, SpainDepartamento de Cirugía y Especialidades Médico-Quirúrgicas, Universidad de Santiago de Compostela, SpainGrupo SINPOS, Departamento de Morfología y Biología Celular, Universidad de Oviedo, Spain; Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago-Providencia, Chile; Corresponding author. Grupo SINPOS, Departamento de Morfología y Biología Celular, Universidad de Oviedo, Spain.Grupo SINPOS, Departamento de Morfología y Biología Celular, Universidad de Oviedo, SpainBackground: Skin biopsy is a minimally invasive and repeatable technique, applicable in any part of the body that can allows for diagnosis and control of treatments, but to analyze Meissner corpuscles biopsy of glabrous skin is necessary it is recommendable obtained the maximal amount it is possible. Changes in density, size, and morphology occurs in several peripheral neuropathies as well as diseases affecting the central nervous system. Methods: We used immunohistochemistry and image analysis to establish differences in the immunohistochemical profile, density, morphology, size and depth relative to the epidermis of Meissner's corpuscles from fingers and toes in a homogeneous age-group. Results: The morphology of Meissner corpuscles was variable. In fingers ellipsoidal non-lobulated corpuscles predominate (about 82%) while in toes most of them showed irregular morphology (60%). No differences between fingers and toes were noted in the basic immunohistochemical profile, except for capsulation. The mean density of Meissner corpuscles was 3,22 ± 0,86/mm2 and 1,15 ± 0,71/mm2, respectively; and the Meissner corpuscles index was 1,09 ± 0,07 and 0,28 ± 0,09, respectively. Regarding the size Meissner corpuscles from the fingers measured 108 ± 24.2 μm x 64 ± 9 μm, and those from toes 87 ± 21.2 μm x 34 ± 6 μm. Finally, the depth relative to the epidermis was 3.6 ± 0.9 μm in fingers and 19 ± 16.2 μm in toes. Conclusion: the study of Meissner corpuscles in cutaneous biopsy from fingers may offer advantages over that from toes because in fingers Meissner's corpuscles are more abundant and superficial, larger, and express more regularly the defining markers of the main corpuscular components.http://www.sciencedirect.com/science/article/pii/S2214854X23000031Meissner's corpuscles densityMeissner's morphometryFingerToeCutaneous biopsyHuman |
| spellingShingle | Patricia Cuendias Rebeca del Rio Olivia García-Suárez Ramón Cobo Marialuisa Aragona Jorge Feito Benjamín Martín-Biedma José A. Vega Yolanda García-Mesa Differences between finger and toe Meissner corpuscles: Searching for the optimal place to analyze meissner corpuscles in cutaneous biopsy Translational Research in Anatomy Meissner's corpuscles density Meissner's morphometry Finger Toe Cutaneous biopsy Human |
| title | Differences between finger and toe Meissner corpuscles: Searching for the optimal place to analyze meissner corpuscles in cutaneous biopsy |
| title_full | Differences between finger and toe Meissner corpuscles: Searching for the optimal place to analyze meissner corpuscles in cutaneous biopsy |
| title_fullStr | Differences between finger and toe Meissner corpuscles: Searching for the optimal place to analyze meissner corpuscles in cutaneous biopsy |
| title_full_unstemmed | Differences between finger and toe Meissner corpuscles: Searching for the optimal place to analyze meissner corpuscles in cutaneous biopsy |
| title_short | Differences between finger and toe Meissner corpuscles: Searching for the optimal place to analyze meissner corpuscles in cutaneous biopsy |
| title_sort | differences between finger and toe meissner corpuscles searching for the optimal place to analyze meissner corpuscles in cutaneous biopsy |
| topic | Meissner's corpuscles density Meissner's morphometry Finger Toe Cutaneous biopsy Human |
| url | http://www.sciencedirect.com/science/article/pii/S2214854X23000031 |
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