TRPM7 Ion Channel: Oncogenic Roles and Therapeutic Potential in Breast Cancer
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a divalent cations permeant channel but also has intrinsic serine/threonine kinase activity. It is ubiquitously expressed in normal tissues and studies have indicated that it participates in important physiological and pharmac...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/24/6322 |
| _version_ | 1797506337006944256 |
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| author | Clément Cordier Natalia Prevarskaya V’yacheslav Lehen’kyi |
| author_facet | Clément Cordier Natalia Prevarskaya V’yacheslav Lehen’kyi |
| author_sort | Clément Cordier |
| collection | DOAJ |
| description | The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a divalent cations permeant channel but also has intrinsic serine/threonine kinase activity. It is ubiquitously expressed in normal tissues and studies have indicated that it participates in important physiological and pharmacological processes through its channel-kinase activity, such as calcium/magnesium homeostasis, phosphorylation of proteins involved in embryogenesis or the cellular process. Accumulating evidence has shown that TRPM7 is overexpressed in human pathologies including breast cancer. Breast cancer is the second leading cause of cancer death in women with an incidence rate increase of around 0.5% per year since 2004. The overexpression of TRPM7 may be associated with a poor prognosis in breast cancer patients, so more efforts are needed to research a new therapeutic target. TRPM7 regulates the levels of Ca<sup>2+</sup>, which can alter the signaling pathways involved in survival, cell cycle progression, proliferation, growth, migration, invasion, epithelial-mesenchymal transition and thus determines cell behavior, promoting tumor development. This work provides a complete overview of the TRPM7 ion channel and its main involvements in breast cancer. Special consideration is given to the modulation of the channel as a potential target in breast cancer treatment by inhibition of proliferation, migration and invasion. Taken together, these data suggest the potential exploitation of TRPM7 channel-kinase as a therapeutic target and a diagnostic biomarker. |
| first_indexed | 2024-03-10T04:32:08Z |
| format | Article |
| id | doaj.art-cc2049f42f334037b12bc7835fffdfc6 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T04:32:08Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-cc2049f42f334037b12bc7835fffdfc62023-11-23T04:07:02ZengMDPI AGCancers2072-66942021-12-011324632210.3390/cancers13246322TRPM7 Ion Channel: Oncogenic Roles and Therapeutic Potential in Breast CancerClément Cordier0Natalia Prevarskaya1V’yacheslav Lehen’kyi2Laboratory of Cell Physiology, INSERM U1003, Laboratory of Excellence Ion Channels Science and Therapeutics, Department of Biology, Faculty of Science and Technologies, University of Lille, 59650 Villeneuve d’Ascq, FranceLaboratory of Cell Physiology, INSERM U1003, Laboratory of Excellence Ion Channels Science and Therapeutics, Department of Biology, Faculty of Science and Technologies, University of Lille, 59650 Villeneuve d’Ascq, FranceLaboratory of Cell Physiology, INSERM U1003, Laboratory of Excellence Ion Channels Science and Therapeutics, Department of Biology, Faculty of Science and Technologies, University of Lille, 59650 Villeneuve d’Ascq, FranceThe transient receptor potential melastatin-subfamily member 7 (TRPM7) is a divalent cations permeant channel but also has intrinsic serine/threonine kinase activity. It is ubiquitously expressed in normal tissues and studies have indicated that it participates in important physiological and pharmacological processes through its channel-kinase activity, such as calcium/magnesium homeostasis, phosphorylation of proteins involved in embryogenesis or the cellular process. Accumulating evidence has shown that TRPM7 is overexpressed in human pathologies including breast cancer. Breast cancer is the second leading cause of cancer death in women with an incidence rate increase of around 0.5% per year since 2004. The overexpression of TRPM7 may be associated with a poor prognosis in breast cancer patients, so more efforts are needed to research a new therapeutic target. TRPM7 regulates the levels of Ca<sup>2+</sup>, which can alter the signaling pathways involved in survival, cell cycle progression, proliferation, growth, migration, invasion, epithelial-mesenchymal transition and thus determines cell behavior, promoting tumor development. This work provides a complete overview of the TRPM7 ion channel and its main involvements in breast cancer. Special consideration is given to the modulation of the channel as a potential target in breast cancer treatment by inhibition of proliferation, migration and invasion. Taken together, these data suggest the potential exploitation of TRPM7 channel-kinase as a therapeutic target and a diagnostic biomarker.https://www.mdpi.com/2072-6694/13/24/6322breast cancerTRPM7chanzymeCa<sup>2+</sup>therapeutic target |
| spellingShingle | Clément Cordier Natalia Prevarskaya V’yacheslav Lehen’kyi TRPM7 Ion Channel: Oncogenic Roles and Therapeutic Potential in Breast Cancer Cancers breast cancer TRPM7 chanzyme Ca<sup>2+</sup> therapeutic target |
| title | TRPM7 Ion Channel: Oncogenic Roles and Therapeutic Potential in Breast Cancer |
| title_full | TRPM7 Ion Channel: Oncogenic Roles and Therapeutic Potential in Breast Cancer |
| title_fullStr | TRPM7 Ion Channel: Oncogenic Roles and Therapeutic Potential in Breast Cancer |
| title_full_unstemmed | TRPM7 Ion Channel: Oncogenic Roles and Therapeutic Potential in Breast Cancer |
| title_short | TRPM7 Ion Channel: Oncogenic Roles and Therapeutic Potential in Breast Cancer |
| title_sort | trpm7 ion channel oncogenic roles and therapeutic potential in breast cancer |
| topic | breast cancer TRPM7 chanzyme Ca<sup>2+</sup> therapeutic target |
| url | https://www.mdpi.com/2072-6694/13/24/6322 |
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