Experimental visceral leishmaniasis in high and low antibody - producer mice (selection IV-A)
Leishmaniasis is a typical parasite infection whose protective immunity depends on macrophage activation. Susceptibility to Leishmania donovani infection was compared in H (high antibody responder) and L (low antibody responder) mice from selection IV-A. H mice infected intravenously with 10(7) amas...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
1999-06-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821999000300002&tlng=en |
| _version_ | 1828515554584952832 |
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| author | Cristiane Jellmayer Fechio Angela Maria Victoriano de Campos Soares Silvio Luís de Oliveira Alexandrina Sartori |
| author_facet | Cristiane Jellmayer Fechio Angela Maria Victoriano de Campos Soares Silvio Luís de Oliveira Alexandrina Sartori |
| author_sort | Cristiane Jellmayer Fechio |
| collection | DOAJ |
| description | Leishmaniasis is a typical parasite infection whose protective immunity depends on macrophage activation. Susceptibility to Leishmania donovani infection was compared in H (high antibody responder) and L (low antibody responder) mice from selection IV-A. H mice infected intravenously with 10(7) amastigotes of L. donovani were more susceptible to infection than their L counterparts. This higher susceptibility was characterized by a higher splenic and hepatic parasite burden. An increased splenic index was observed in both lines after sixty days of infection. This splenomegaly was caused, at least partially, by an increase in the number of splenic cells as determined by direct counts of cells from spleen. The results show that selection IV-A is susceptible to visceral leishmaniasis, with the H line being more susceptible than the L line. |
| first_indexed | 2024-12-11T18:14:43Z |
| format | Article |
| id | doaj.art-cc21ab5a56dc44c79b8678ac73099d49 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-11T18:14:43Z |
| publishDate | 1999-06-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-cc21ab5a56dc44c79b8678ac73099d492022-12-22T00:55:27ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98491999-06-01323229234Experimental visceral leishmaniasis in high and low antibody - producer mice (selection IV-A)Cristiane Jellmayer Fechio0Angela Maria Victoriano de Campos Soares1Silvio Luís de Oliveira2Alexandrina Sartori3Universidade Estadual Paulista (UNESP)Universidade Estadual Paulista (UNESP)Universidade Estadual Paulista (UNESP)Universidade Estadual Paulista (UNESP)Leishmaniasis is a typical parasite infection whose protective immunity depends on macrophage activation. Susceptibility to Leishmania donovani infection was compared in H (high antibody responder) and L (low antibody responder) mice from selection IV-A. H mice infected intravenously with 10(7) amastigotes of L. donovani were more susceptible to infection than their L counterparts. This higher susceptibility was characterized by a higher splenic and hepatic parasite burden. An increased splenic index was observed in both lines after sixty days of infection. This splenomegaly was caused, at least partially, by an increase in the number of splenic cells as determined by direct counts of cells from spleen. The results show that selection IV-A is susceptible to visceral leishmaniasis, with the H line being more susceptible than the L line.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821999000300002&tlng=enLeishmania donovaniBiozzi mice |
| spellingShingle | Cristiane Jellmayer Fechio Angela Maria Victoriano de Campos Soares Silvio Luís de Oliveira Alexandrina Sartori Experimental visceral leishmaniasis in high and low antibody - producer mice (selection IV-A) Revista da Sociedade Brasileira de Medicina Tropical Leishmania donovani Biozzi mice |
| title | Experimental visceral leishmaniasis in high and low antibody - producer mice (selection IV-A) |
| title_full | Experimental visceral leishmaniasis in high and low antibody - producer mice (selection IV-A) |
| title_fullStr | Experimental visceral leishmaniasis in high and low antibody - producer mice (selection IV-A) |
| title_full_unstemmed | Experimental visceral leishmaniasis in high and low antibody - producer mice (selection IV-A) |
| title_short | Experimental visceral leishmaniasis in high and low antibody - producer mice (selection IV-A) |
| title_sort | experimental visceral leishmaniasis in high and low antibody producer mice selection iv a |
| topic | Leishmania donovani Biozzi mice |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821999000300002&tlng=en |
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