Choline Glycerophospholipid-Derived Prostaglandins Attenuate TNFα Gene Expression in Macrophages via a cPLA<sub>2</sub>α/COX-1 Pathway

Choline Glycerophospholipid-Derived Prostaglandins Attenuate TNFα Gene Expression in Macrophages via a cPLA<sub>2</sub>α/COX-1 Pathway

Macrophages are professional antigen presenting cells with intense phagocytic activity, strategically distributed in tissues and cavities. These cells are capable of responding to a wide variety of innate inflammatory stimuli, many of which are signaled by lipid mediators. The distribution of arachi...

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Bibliographic Details
Main Authors: Alma M. Astudillo, Juan P. Rodríguez, Carlos Guijas, Julio M. Rubio, María A. Balboa, Jesús Balsinde
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
arachidonic acid
eicosanoids
phospholipid remodeling
phospholipase A<sub>2</sub>
inflammation
monocytes/macrophages
Online Access:https://www.mdpi.com/2073-4409/10/2/447

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