Vitamin D and Its Role on the Fatigue Mitigation: A Narrative Review
Vitamin D has historically been associated with bone metabolism. However, over the years, a growing body of evidence has emerged indicating its involvement in various physiological processes that may influence the onset of numerous pathologies (cardiovascular and neurodegenerative diseases, rheumato...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/2/221 |
| _version_ | 1797339505093509120 |
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| author | Ippolita Valentina Di Molfetta Laura Bordoni Rosita Gabbianelli Gianni Sagratini Laura Alessandroni |
| author_facet | Ippolita Valentina Di Molfetta Laura Bordoni Rosita Gabbianelli Gianni Sagratini Laura Alessandroni |
| author_sort | Ippolita Valentina Di Molfetta |
| collection | DOAJ |
| description | Vitamin D has historically been associated with bone metabolism. However, over the years, a growing body of evidence has emerged indicating its involvement in various physiological processes that may influence the onset of numerous pathologies (cardiovascular and neurodegenerative diseases, rheumatological diseases, fertility, cancer, diabetes, or a condition of fatigue). This narrative review investigates the current knowledge of the pathophysiological mechanisms underlying fatigue and the ways in which vitamin D is implicated in these processes. Scientific studies in the databases of PubMed, Scopus, and Web of Science were reviewed with a focus on factors that play a role in the genesis of fatigue, where the influence of vitamin D has been clearly demonstrated. The pathogenic factors of fatigue influenced by vitamin D are related to biochemical factors connected to oxidative stress and inflammatory cytokines. A role in the control of the neurotransmitters dopamine and serotonin has also been demonstrated: an imbalance in the relationship between these two neurotransmitters is linked to the genesis of fatigue. Furthermore, vitamin D is implicated in the control of voltage-gated calcium and chloride channels. Although it has been demonstrated that hypovitaminosis D is associated with numerous pathological conditions, current data on the outcomes of correcting hypovitaminosis D are conflicting. This suggests that, despite the significant involvement of vitamin D in regulating mechanisms governing fatigue, other factors could also play a role. |
| first_indexed | 2024-03-08T09:49:07Z |
| format | Article |
| id | doaj.art-cc21db6259834a24b0a67d1f6c3f73a0 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-08T09:49:07Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-cc21db6259834a24b0a67d1f6c3f73a02024-01-29T14:09:49ZengMDPI AGNutrients2072-66432024-01-0116222110.3390/nu16020221Vitamin D and Its Role on the Fatigue Mitigation: A Narrative ReviewIppolita Valentina Di Molfetta0Laura Bordoni1Rosita Gabbianelli2Gianni Sagratini3Laura Alessandroni4Chemistry Interdisciplinary Project, School of Pharmacy, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, ItalyUnit of Molecular Biology and Nutrigenomics, School of Pharmacy, University of Camerino, Via Gentile III da Varano, 62032 Camerino, ItalyUnit of Molecular Biology and Nutrigenomics, School of Pharmacy, University of Camerino, Via Gentile III da Varano, 62032 Camerino, ItalyChemistry Interdisciplinary Project, School of Pharmacy, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, ItalyChemistry Interdisciplinary Project, School of Pharmacy, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, ItalyVitamin D has historically been associated with bone metabolism. However, over the years, a growing body of evidence has emerged indicating its involvement in various physiological processes that may influence the onset of numerous pathologies (cardiovascular and neurodegenerative diseases, rheumatological diseases, fertility, cancer, diabetes, or a condition of fatigue). This narrative review investigates the current knowledge of the pathophysiological mechanisms underlying fatigue and the ways in which vitamin D is implicated in these processes. Scientific studies in the databases of PubMed, Scopus, and Web of Science were reviewed with a focus on factors that play a role in the genesis of fatigue, where the influence of vitamin D has been clearly demonstrated. The pathogenic factors of fatigue influenced by vitamin D are related to biochemical factors connected to oxidative stress and inflammatory cytokines. A role in the control of the neurotransmitters dopamine and serotonin has also been demonstrated: an imbalance in the relationship between these two neurotransmitters is linked to the genesis of fatigue. Furthermore, vitamin D is implicated in the control of voltage-gated calcium and chloride channels. Although it has been demonstrated that hypovitaminosis D is associated with numerous pathological conditions, current data on the outcomes of correcting hypovitaminosis D are conflicting. This suggests that, despite the significant involvement of vitamin D in regulating mechanisms governing fatigue, other factors could also play a role.https://www.mdpi.com/2072-6643/16/2/221vitamin Doxidative stressneurotransmitterschronic fatiguemusculoskeletal disorders |
| spellingShingle | Ippolita Valentina Di Molfetta Laura Bordoni Rosita Gabbianelli Gianni Sagratini Laura Alessandroni Vitamin D and Its Role on the Fatigue Mitigation: A Narrative Review Nutrients vitamin D oxidative stress neurotransmitters chronic fatigue musculoskeletal disorders |
| title | Vitamin D and Its Role on the Fatigue Mitigation: A Narrative Review |
| title_full | Vitamin D and Its Role on the Fatigue Mitigation: A Narrative Review |
| title_fullStr | Vitamin D and Its Role on the Fatigue Mitigation: A Narrative Review |
| title_full_unstemmed | Vitamin D and Its Role on the Fatigue Mitigation: A Narrative Review |
| title_short | Vitamin D and Its Role on the Fatigue Mitigation: A Narrative Review |
| title_sort | vitamin d and its role on the fatigue mitigation a narrative review |
| topic | vitamin D oxidative stress neurotransmitters chronic fatigue musculoskeletal disorders |
| url | https://www.mdpi.com/2072-6643/16/2/221 |
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