Cancer becomes wasteful: emerging roles of exosomes in cell-fate determination
Extracellular vesicles (EVs), including exosomes, have been widely recognized for their role in intercellular communication of the immune response system. In the past few years, significance has been given to exosomes in the induction and modulation of cell-fate-inducing signalling pathways, such as...
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| Format: | Article |
| Language: | English |
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Wiley
2013-09-01
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| Series: | Journal of Extracellular Vesicles |
| Subjects: | |
| Online Access: | http://www.journalofextracellularvesicles.net/index.php/jev/article/download/22390/30366 |
| _version_ | 1818914901502984192 |
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| author | Franz Wendler Neus Bota-Rabassedas Xavier Franch-Marro |
| author_facet | Franz Wendler Neus Bota-Rabassedas Xavier Franch-Marro |
| author_sort | Franz Wendler |
| collection | DOAJ |
| description | Extracellular vesicles (EVs), including exosomes, have been widely recognized for their role in intercellular communication of the immune response system. In the past few years, significance has been given to exosomes in the induction and modulation of cell-fate-inducing signalling pathways, such as the Hedgehog (Hh), Wnts, Notch, transforming growth factor (TGF-β), epidermal growth factor (EGF) and fibroblast growth factor (FGF) pathways, placing them in the wider context of development and also of cancer. These protein families induce signalling cascades responsible for tissue specification, homeostasis and maintenance. Exosomes contribute to cell-fate signal secretion, and vice versa exosome secretion can be induced by these proteins. Interestingly, exosomes can also transfer their mRNA to host cells or modulate the signalling pathways directly by the removal of downstream effector molecules from the cell. Surprisingly, much of what we know about the function of exosomes in cell determination is gathered from pathological transformed cancer cells and wound healing while data about their biogenesis and biology in normal developing and adult tissue lag behind. In this report, we will summarize some of the published literature and point to current advances and questions in this fast-developing topic. In a brief foray, we will also update and shortly discuss their potential in diagnosis and targeted cancer treatment. |
| first_indexed | 2024-12-19T23:53:45Z |
| format | Article |
| id | doaj.art-cc22250c4d384e2a8e7ab9c8f32303a7 |
| institution | Directory Open Access Journal |
| issn | 2001-3078 |
| language | English |
| last_indexed | 2024-12-19T23:53:45Z |
| publishDate | 2013-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Extracellular Vesicles |
| spelling | doaj.art-cc22250c4d384e2a8e7ab9c8f32303a72022-12-21T20:01:05ZengWileyJournal of Extracellular Vesicles2001-30782013-09-01201910.3402/jev.v2i0.22390Cancer becomes wasteful: emerging roles of exosomes in cell-fate determinationFranz WendlerNeus Bota-RabassedasXavier Franch-MarroExtracellular vesicles (EVs), including exosomes, have been widely recognized for their role in intercellular communication of the immune response system. In the past few years, significance has been given to exosomes in the induction and modulation of cell-fate-inducing signalling pathways, such as the Hedgehog (Hh), Wnts, Notch, transforming growth factor (TGF-β), epidermal growth factor (EGF) and fibroblast growth factor (FGF) pathways, placing them in the wider context of development and also of cancer. These protein families induce signalling cascades responsible for tissue specification, homeostasis and maintenance. Exosomes contribute to cell-fate signal secretion, and vice versa exosome secretion can be induced by these proteins. Interestingly, exosomes can also transfer their mRNA to host cells or modulate the signalling pathways directly by the removal of downstream effector molecules from the cell. Surprisingly, much of what we know about the function of exosomes in cell determination is gathered from pathological transformed cancer cells and wound healing while data about their biogenesis and biology in normal developing and adult tissue lag behind. In this report, we will summarize some of the published literature and point to current advances and questions in this fast-developing topic. In a brief foray, we will also update and shortly discuss their potential in diagnosis and targeted cancer treatment.www.journalofextracellularvesicles.net/index.php/jev/article/download/22390/30366multivesicular body (MVB)extracellular vesiclesexosomescell-fate ligandssecretionsignalling pathways |
| spellingShingle | Franz Wendler Neus Bota-Rabassedas Xavier Franch-Marro Cancer becomes wasteful: emerging roles of exosomes in cell-fate determination Journal of Extracellular Vesicles multivesicular body (MVB) extracellular vesicles exosomes cell-fate ligands secretion signalling pathways |
| title | Cancer becomes wasteful: emerging roles of exosomes in cell-fate determination |
| title_full | Cancer becomes wasteful: emerging roles of exosomes in cell-fate determination |
| title_fullStr | Cancer becomes wasteful: emerging roles of exosomes in cell-fate determination |
| title_full_unstemmed | Cancer becomes wasteful: emerging roles of exosomes in cell-fate determination |
| title_short | Cancer becomes wasteful: emerging roles of exosomes in cell-fate determination |
| title_sort | cancer becomes wasteful emerging roles of exosomes in cell fate determination |
| topic | multivesicular body (MVB) extracellular vesicles exosomes cell-fate ligands secretion signalling pathways |
| url | http://www.journalofextracellularvesicles.net/index.php/jev/article/download/22390/30366 |
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