Phenotype assessment for neurodegenerative murine models with ataxia and application to Niemann–Pick disease, type C1

Phenotype assessment for neurodegenerative murine models with ataxia and application to Niemann–Pick disease, type C1

Identifying meaningful predictors of therapeutic efficacy from preclinical studies is challenging. However, clinical manifestations occurring in both patients and mammalian models offer significant translational value. Many neurological disorders, including inherited, metabolic Niemann–Pick disease,...

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Bibliographic Details
Main Authors: Julia Yerger, Antony C. Cougnoux, Craig B. Abbott, Rachel Luke, Tannia S. Clark, Niamh X. Cawley, Forbes D. Porter, Cristin D. Davidson
Format: Article
Language:English
Published: The Company of Biologists 2022-04-01
Series:Biology Open
Subjects:
niemann–pick disease
type c
cerebellar ataxia
npc1
neurological disease
phenotype assessment
lysosomal disease
Online Access:http://bio.biologists.org/content/11/4/bio059052

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