DRUG INDUCED ACUTE TUBULAR NECROSIS – RARE CASE OF NEPHROTIC SYNDROME
We presented two cases of nephrotic syndrome (NS) drug-induced with tubular nephrotoxicity, with different evolution in the context of etiologic diseases. First is 5-month-old girl admitted with NS (clinically and biological proven) and acute renal failure after another hospitalization for pneumo...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2015-12-01
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| Series: | Romanian Journal of Pediatrics |
| Subjects: | |
| Online Access: | https://revistemedicale.amaltea.ro/Romanian_Journal_of_PEDIATRICS/Revista_Romana_de_PEDIATRIE-2015-Nr.4/EN/RJP_2015_4_EN_Art-11.pdf |
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| author | Magdalena Starcea Mihaela Munteanu Radu Russu Anca Iulia Rotaru Doina Mihaila Ingrith Miron |
| author_facet | Magdalena Starcea Mihaela Munteanu Radu Russu Anca Iulia Rotaru Doina Mihaila Ingrith Miron |
| author_sort | Magdalena Starcea |
| collection | DOAJ |
| description | We presented two cases of nephrotic syndrome (NS) drug-induced with tubular nephrotoxicity, with different
evolution in the context of etiologic diseases.
First is 5-month-old girl admitted with NS (clinically and biological proven) and acute renal failure after another
hospitalization for pneumonia. The girl was treated with ceftriaxone and gentamicin 12 days. Congenital NS
suspicion was eliminated by renal biopsy who revealed renal tubular necrosis highlighting recovery phase. The
development was favorable in 7 days of peritoneal dialysis.
The second case was 16 years old adolescents treated 3 years with carbimazol for Basedow disease. Was
presented with nephrotic syndrome not influenced by corticosteroids. Histopathology revealed toxic tubular
necrosis, interstitial fibrosis, absence of glomerular injury. Nephrotoxic treatment was stopped, and, after thyroidectomy, edema were reduced, but kidney function continued to depreciate, while nephrotoxic therapy given
for 3 years.
Conclusions. Renal tubular necrosis clinical and laboratory expressed by nephrotic syndrome, accompanied by renal insufficiency is a rare occurrence in children; gentamicin and carbimazol can be criminalized. The suffering or impairment may be improved by removing the causative drug. Treatment failure was associated with duration of drug aggression and evolution of comorbidities. |
| first_indexed | 2024-12-19T20:58:12Z |
| format | Article |
| id | doaj.art-cc238e72b4e4417c8f6ba7b20e572e97 |
| institution | Directory Open Access Journal |
| issn | 1454-0398 2069-6175 |
| language | English |
| last_indexed | 2024-12-19T20:58:12Z |
| publishDate | 2015-12-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Pediatrics |
| spelling | doaj.art-cc238e72b4e4417c8f6ba7b20e572e972022-12-21T20:05:54ZengAmaltea Medical Publishing HouseRomanian Journal of Pediatrics1454-03982069-61752015-12-0164441041210.37897/RJP.2015.4.11DRUG INDUCED ACUTE TUBULAR NECROSIS – RARE CASE OF NEPHROTIC SYNDROMEMagdalena Starcea0Mihaela Munteanu1Radu Russu2Anca Iulia Rotaru3Doina Mihaila4Ingrith Miron5“Gr. T. Popa” University of Medicine and Pharmacy, Iasi; Department of Pediatric Nephrology, “Sf. Maria” Emergency Clinical Hospital for Children, IasiDepartment of Pediatric Nephrology, “Sf. Maria” Emergency Clinical Hospital for Children, IasiDepartment of Pediatric Nephrology, “Sf. Maria” Emergency Clinical Hospital for Children, IasiDepartment of Pediatric Nephrology, “Sf. Maria” Emergency Clinical Hospital for Children, IasiLaboratory of Pathology, “Sf. Maria” Emergency Clinical Hospital for Children, Iasi“Gr. T. Popa” University of Medicine and Pharmacy, Iasi; Department of Pediatric Nephrology, “Sf. Maria” Emergency Clinical Hospital for Children, IasiWe presented two cases of nephrotic syndrome (NS) drug-induced with tubular nephrotoxicity, with different evolution in the context of etiologic diseases. First is 5-month-old girl admitted with NS (clinically and biological proven) and acute renal failure after another hospitalization for pneumonia. The girl was treated with ceftriaxone and gentamicin 12 days. Congenital NS suspicion was eliminated by renal biopsy who revealed renal tubular necrosis highlighting recovery phase. The development was favorable in 7 days of peritoneal dialysis. The second case was 16 years old adolescents treated 3 years with carbimazol for Basedow disease. Was presented with nephrotic syndrome not influenced by corticosteroids. Histopathology revealed toxic tubular necrosis, interstitial fibrosis, absence of glomerular injury. Nephrotoxic treatment was stopped, and, after thyroidectomy, edema were reduced, but kidney function continued to depreciate, while nephrotoxic therapy given for 3 years. Conclusions. Renal tubular necrosis clinical and laboratory expressed by nephrotic syndrome, accompanied by renal insufficiency is a rare occurrence in children; gentamicin and carbimazol can be criminalized. The suffering or impairment may be improved by removing the causative drug. Treatment failure was associated with duration of drug aggression and evolution of comorbidities.https://revistemedicale.amaltea.ro/Romanian_Journal_of_PEDIATRICS/Revista_Romana_de_PEDIATRIE-2015-Nr.4/EN/RJP_2015_4_EN_Art-11.pdfacute tubular necrosisnephrotic syndromeacute renal failure |
| spellingShingle | Magdalena Starcea Mihaela Munteanu Radu Russu Anca Iulia Rotaru Doina Mihaila Ingrith Miron DRUG INDUCED ACUTE TUBULAR NECROSIS – RARE CASE OF NEPHROTIC SYNDROME Romanian Journal of Pediatrics acute tubular necrosis nephrotic syndrome acute renal failure |
| title | DRUG INDUCED ACUTE TUBULAR NECROSIS – RARE CASE OF NEPHROTIC SYNDROME |
| title_full | DRUG INDUCED ACUTE TUBULAR NECROSIS – RARE CASE OF NEPHROTIC SYNDROME |
| title_fullStr | DRUG INDUCED ACUTE TUBULAR NECROSIS – RARE CASE OF NEPHROTIC SYNDROME |
| title_full_unstemmed | DRUG INDUCED ACUTE TUBULAR NECROSIS – RARE CASE OF NEPHROTIC SYNDROME |
| title_short | DRUG INDUCED ACUTE TUBULAR NECROSIS – RARE CASE OF NEPHROTIC SYNDROME |
| title_sort | drug induced acute tubular necrosis rare case of nephrotic syndrome |
| topic | acute tubular necrosis nephrotic syndrome acute renal failure |
| url | https://revistemedicale.amaltea.ro/Romanian_Journal_of_PEDIATRICS/Revista_Romana_de_PEDIATRIE-2015-Nr.4/EN/RJP_2015_4_EN_Art-11.pdf |
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