The effects of panax ginseng on lipid profile, pro-oxidant: Antioxidant status and high-sensitivity c reactive protein levels in hyperlipidemic patients in Iran

Background: Because of the conflicting results from previous studies regarding the efficacy of ginseng on lipid profile and anti-inflammatory and anti-proliferative activities of its components, we aimed to evaluate the effects of Panax ginseng on lipid profile, pro-oxidant - anti-oxidant status and...

Full description

Bibliographic Details
Main Authors: Mahdy Hassanzadeh Delui, Hedayatollah Fatehi, Morteza Manavifar, Maral Amini, Majid Ghayour-Mobarhan, Mahdi Zahedi, Gordon Ferns
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2013-01-01
Series:International Journal of Preventive Medicine
Subjects:
Online Access:http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2013;volume=4;issue=9;spage=1045;epage=1051;aulast=Delui
_version_ 1828868935235141632
author Mahdy Hassanzadeh Delui
Hedayatollah Fatehi
Morteza Manavifar
Maral Amini
Majid Ghayour-Mobarhan
Mahdi Zahedi
Gordon Ferns
author_facet Mahdy Hassanzadeh Delui
Hedayatollah Fatehi
Morteza Manavifar
Maral Amini
Majid Ghayour-Mobarhan
Mahdi Zahedi
Gordon Ferns
author_sort Mahdy Hassanzadeh Delui
collection DOAJ
description Background: Because of the conflicting results from previous studies regarding the efficacy of ginseng on lipid profile and anti-inflammatory and anti-proliferative activities of its components, we aimed to evaluate the effects of Panax ginseng on lipid profile, pro-oxidant - anti-oxidant status and high-sensitivity C reactive protein (hs-CRP) levels. Methods: Forty Iranian hyperlipidemic patients were randomly assigned to placebo (n = 20) or control (n = 20) groups in this double-blind randomized controlled trial. The ginseng or placebo was taken two capsules twice a day for 8 weeks. Total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose, serum creatinine and hs-CRP levels and pro-oxidant - anti-oxidant balance (PAB) were estimated before and after intervention. Results: There were no significant differences between the two groups with respect to changes in serum TG, LDL-C, HDL-C, and TC/HDL-C levels. Nor were there significant differences between the two groups with respect to changes in hs-CRP level and PAB from baseline to week 8. Conclusions: Our study demonstrates that ginseng does not have significant effects on lipid profile, Hs-CRP level and PAB. Further clinical studies, with a larger sample size, more prolonged period of therapy are needed to investigate the therapeutic effects of ginseng.
first_indexed 2024-12-13T05:40:03Z
format Article
id doaj.art-cc23c3e058aa414c8c8af1b5b443219c
institution Directory Open Access Journal
issn 2008-7802
2008-8213
language English
last_indexed 2024-12-13T05:40:03Z
publishDate 2013-01-01
publisher Wolters Kluwer Medknow Publications
record_format Article
series International Journal of Preventive Medicine
spelling doaj.art-cc23c3e058aa414c8c8af1b5b443219c2022-12-21T23:57:48ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132013-01-014910451051The effects of panax ginseng on lipid profile, pro-oxidant: Antioxidant status and high-sensitivity c reactive protein levels in hyperlipidemic patients in IranMahdy Hassanzadeh DeluiHedayatollah FatehiMorteza ManavifarMaral AminiMajid Ghayour-MobarhanMahdi ZahediGordon FernsBackground: Because of the conflicting results from previous studies regarding the efficacy of ginseng on lipid profile and anti-inflammatory and anti-proliferative activities of its components, we aimed to evaluate the effects of Panax ginseng on lipid profile, pro-oxidant - anti-oxidant status and high-sensitivity C reactive protein (hs-CRP) levels. Methods: Forty Iranian hyperlipidemic patients were randomly assigned to placebo (n = 20) or control (n = 20) groups in this double-blind randomized controlled trial. The ginseng or placebo was taken two capsules twice a day for 8 weeks. Total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose, serum creatinine and hs-CRP levels and pro-oxidant - anti-oxidant balance (PAB) were estimated before and after intervention. Results: There were no significant differences between the two groups with respect to changes in serum TG, LDL-C, HDL-C, and TC/HDL-C levels. Nor were there significant differences between the two groups with respect to changes in hs-CRP level and PAB from baseline to week 8. Conclusions: Our study demonstrates that ginseng does not have significant effects on lipid profile, Hs-CRP level and PAB. Further clinical studies, with a larger sample size, more prolonged period of therapy are needed to investigate the therapeutic effects of ginseng.http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2013;volume=4;issue=9;spage=1045;epage=1051;aulast=DeluiHigh sensitivity C reactive proteinlipid profilePanax ginsengpro-oxidant - anti-oxidant status
spellingShingle Mahdy Hassanzadeh Delui
Hedayatollah Fatehi
Morteza Manavifar
Maral Amini
Majid Ghayour-Mobarhan
Mahdi Zahedi
Gordon Ferns
The effects of panax ginseng on lipid profile, pro-oxidant: Antioxidant status and high-sensitivity c reactive protein levels in hyperlipidemic patients in Iran
International Journal of Preventive Medicine
High sensitivity C reactive protein
lipid profile
Panax ginseng
pro-oxidant - anti-oxidant status
title The effects of panax ginseng on lipid profile, pro-oxidant: Antioxidant status and high-sensitivity c reactive protein levels in hyperlipidemic patients in Iran
title_full The effects of panax ginseng on lipid profile, pro-oxidant: Antioxidant status and high-sensitivity c reactive protein levels in hyperlipidemic patients in Iran
title_fullStr The effects of panax ginseng on lipid profile, pro-oxidant: Antioxidant status and high-sensitivity c reactive protein levels in hyperlipidemic patients in Iran
title_full_unstemmed The effects of panax ginseng on lipid profile, pro-oxidant: Antioxidant status and high-sensitivity c reactive protein levels in hyperlipidemic patients in Iran
title_short The effects of panax ginseng on lipid profile, pro-oxidant: Antioxidant status and high-sensitivity c reactive protein levels in hyperlipidemic patients in Iran
title_sort effects of panax ginseng on lipid profile pro oxidant antioxidant status and high sensitivity c reactive protein levels in hyperlipidemic patients in iran
topic High sensitivity C reactive protein
lipid profile
Panax ginseng
pro-oxidant - anti-oxidant status
url http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2013;volume=4;issue=9;spage=1045;epage=1051;aulast=Delui
work_keys_str_mv AT mahdyhassanzadehdelui theeffectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran
AT hedayatollahfatehi theeffectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran
AT mortezamanavifar theeffectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran
AT maralamini theeffectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran
AT majidghayourmobarhan theeffectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran
AT mahdizahedi theeffectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran
AT gordonferns theeffectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran
AT mahdyhassanzadehdelui effectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran
AT hedayatollahfatehi effectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran
AT mortezamanavifar effectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran
AT maralamini effectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran
AT majidghayourmobarhan effectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran
AT mahdizahedi effectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran
AT gordonferns effectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran