The effects of panax ginseng on lipid profile, pro-oxidant: Antioxidant status and high-sensitivity c reactive protein levels in hyperlipidemic patients in Iran
Background: Because of the conflicting results from previous studies regarding the efficacy of ginseng on lipid profile and anti-inflammatory and anti-proliferative activities of its components, we aimed to evaluate the effects of Panax ginseng on lipid profile, pro-oxidant - anti-oxidant status and...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2013-01-01
|
Series: | International Journal of Preventive Medicine |
Subjects: | |
Online Access: | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2013;volume=4;issue=9;spage=1045;epage=1051;aulast=Delui |
_version_ | 1828868935235141632 |
---|---|
author | Mahdy Hassanzadeh Delui Hedayatollah Fatehi Morteza Manavifar Maral Amini Majid Ghayour-Mobarhan Mahdi Zahedi Gordon Ferns |
author_facet | Mahdy Hassanzadeh Delui Hedayatollah Fatehi Morteza Manavifar Maral Amini Majid Ghayour-Mobarhan Mahdi Zahedi Gordon Ferns |
author_sort | Mahdy Hassanzadeh Delui |
collection | DOAJ |
description | Background: Because of the conflicting results from previous studies regarding the efficacy of ginseng on lipid profile and anti-inflammatory and anti-proliferative activities of its components, we aimed to evaluate the effects of Panax ginseng on lipid profile, pro-oxidant - anti-oxidant status and high-sensitivity C reactive protein (hs-CRP) levels.
Methods: Forty Iranian hyperlipidemic patients were randomly assigned to placebo (n = 20) or control (n = 20) groups in this double-blind randomized controlled trial. The ginseng or placebo was taken two capsules twice a day for 8 weeks. Total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose, serum creatinine and hs-CRP levels and pro-oxidant - anti-oxidant balance (PAB) were estimated before and after intervention.
Results: There were no significant differences between the two groups with respect to changes in serum TG, LDL-C, HDL-C, and TC/HDL-C levels. Nor were there significant differences between the two groups with respect to changes in hs-CRP level and PAB from baseline to week 8.
Conclusions: Our study demonstrates that ginseng does not have significant effects on lipid profile, Hs-CRP level and PAB. Further clinical studies, with a larger sample size, more prolonged period of therapy are needed to investigate the therapeutic effects of ginseng. |
first_indexed | 2024-12-13T05:40:03Z |
format | Article |
id | doaj.art-cc23c3e058aa414c8c8af1b5b443219c |
institution | Directory Open Access Journal |
issn | 2008-7802 2008-8213 |
language | English |
last_indexed | 2024-12-13T05:40:03Z |
publishDate | 2013-01-01 |
publisher | Wolters Kluwer Medknow Publications |
record_format | Article |
series | International Journal of Preventive Medicine |
spelling | doaj.art-cc23c3e058aa414c8c8af1b5b443219c2022-12-21T23:57:48ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132013-01-014910451051The effects of panax ginseng on lipid profile, pro-oxidant: Antioxidant status and high-sensitivity c reactive protein levels in hyperlipidemic patients in IranMahdy Hassanzadeh DeluiHedayatollah FatehiMorteza ManavifarMaral AminiMajid Ghayour-MobarhanMahdi ZahediGordon FernsBackground: Because of the conflicting results from previous studies regarding the efficacy of ginseng on lipid profile and anti-inflammatory and anti-proliferative activities of its components, we aimed to evaluate the effects of Panax ginseng on lipid profile, pro-oxidant - anti-oxidant status and high-sensitivity C reactive protein (hs-CRP) levels. Methods: Forty Iranian hyperlipidemic patients were randomly assigned to placebo (n = 20) or control (n = 20) groups in this double-blind randomized controlled trial. The ginseng or placebo was taken two capsules twice a day for 8 weeks. Total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose, serum creatinine and hs-CRP levels and pro-oxidant - anti-oxidant balance (PAB) were estimated before and after intervention. Results: There were no significant differences between the two groups with respect to changes in serum TG, LDL-C, HDL-C, and TC/HDL-C levels. Nor were there significant differences between the two groups with respect to changes in hs-CRP level and PAB from baseline to week 8. Conclusions: Our study demonstrates that ginseng does not have significant effects on lipid profile, Hs-CRP level and PAB. Further clinical studies, with a larger sample size, more prolonged period of therapy are needed to investigate the therapeutic effects of ginseng.http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2013;volume=4;issue=9;spage=1045;epage=1051;aulast=DeluiHigh sensitivity C reactive proteinlipid profilePanax ginsengpro-oxidant - anti-oxidant status |
spellingShingle | Mahdy Hassanzadeh Delui Hedayatollah Fatehi Morteza Manavifar Maral Amini Majid Ghayour-Mobarhan Mahdi Zahedi Gordon Ferns The effects of panax ginseng on lipid profile, pro-oxidant: Antioxidant status and high-sensitivity c reactive protein levels in hyperlipidemic patients in Iran International Journal of Preventive Medicine High sensitivity C reactive protein lipid profile Panax ginseng pro-oxidant - anti-oxidant status |
title | The effects of panax ginseng on lipid profile, pro-oxidant: Antioxidant status and high-sensitivity c reactive protein levels in hyperlipidemic patients in Iran |
title_full | The effects of panax ginseng on lipid profile, pro-oxidant: Antioxidant status and high-sensitivity c reactive protein levels in hyperlipidemic patients in Iran |
title_fullStr | The effects of panax ginseng on lipid profile, pro-oxidant: Antioxidant status and high-sensitivity c reactive protein levels in hyperlipidemic patients in Iran |
title_full_unstemmed | The effects of panax ginseng on lipid profile, pro-oxidant: Antioxidant status and high-sensitivity c reactive protein levels in hyperlipidemic patients in Iran |
title_short | The effects of panax ginseng on lipid profile, pro-oxidant: Antioxidant status and high-sensitivity c reactive protein levels in hyperlipidemic patients in Iran |
title_sort | effects of panax ginseng on lipid profile pro oxidant antioxidant status and high sensitivity c reactive protein levels in hyperlipidemic patients in iran |
topic | High sensitivity C reactive protein lipid profile Panax ginseng pro-oxidant - anti-oxidant status |
url | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2013;volume=4;issue=9;spage=1045;epage=1051;aulast=Delui |
work_keys_str_mv | AT mahdyhassanzadehdelui theeffectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran AT hedayatollahfatehi theeffectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran AT mortezamanavifar theeffectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran AT maralamini theeffectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran AT majidghayourmobarhan theeffectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran AT mahdizahedi theeffectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran AT gordonferns theeffectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran AT mahdyhassanzadehdelui effectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran AT hedayatollahfatehi effectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran AT mortezamanavifar effectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran AT maralamini effectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran AT majidghayourmobarhan effectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran AT mahdizahedi effectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran AT gordonferns effectsofpanaxginsengonlipidprofileprooxidantantioxidantstatusandhighsensitivitycreactiveproteinlevelsinhyperlipidemicpatientsiniran |