High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing

High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing

Abstract The mammary gland undergoes hormonally stimulated cycles of proliferation, lactation, and involution. We hypothesized that these factors increase the mutational burden in glandular tissue and may explain high cancer incidence rate in the general population, and recurrent disease. Hence, we...

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Main Authors: Anna Kostecka, Tomasz Nowikiewicz, Paweł Olszewski, Magdalena Koczkowska, Monika Horbacz, Monika Heinzl, Maria Andreou, Renato Salazar, Theresa Mair, Piotr Madanecki, Magdalena Gucwa, Hanna Davies, Jarosław Skokowski, Patrick G. Buckley, Rafał Pęksa, Ewa Śrutek, Łukasz Szylberg, Johan Hartman, Michał Jankowski, Wojciech Zegarski, Irene Tiemann-Boege, Jan P. Dumanski, Arkadiusz Piotrowski
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-022-00443-9

Internet

https://doi.org/10.1038/s41523-022-00443-9

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