Unraveling the causal genes and transcriptomic determinants of human telomere length

Unraveling the causal genes and transcriptomic determinants of human telomere length

Abstract Telomere length (TL) shortening is a pivotal indicator of biological aging and is associated with many human diseases. The genetic determinates of human TL have been widely investigated, however, most existing studies were conducted based on adult tissues which are heavily influenced by lif...

Full description

Bibliographic Details
Main Authors:	Ying Chang, Yao Zhou, Junrui Zhou, Wen Li, Jiasong Cao, Yaqing Jing, Shan Zhang, Yongmei Shen, Qimei Lin, Xutong Fan, Hongxi Yang, Xiaobao Dong, Shijie Zhang, Xianfu Yi, Ling Shuai, Lei Shi, Zhe Liu, Jie Yang, Xin Ma, Jihui Hao, Kexin Chen, Mulin Jun Li, Feng Wang, Dandan Huang
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-023-44355-z

Similar Items

Unraveling the causal association between leukocyte telomere length and infertility: A two-sample Mendelian randomization study.
by: Gaole An, et al.
Published: (2024-01-01)

Interrogating cell type-specific cooperation of transcriptional regulators in 3D chromatin
by: Xianfu Yi, et al.
Published: (2021-12-01)

Quantum causal unravelling
by: Ge Bai, et al.
Published: (2022-06-01)

Exploring 3D chromatin contacts in gene regulation: The evolution of approaches for the identification of functional enhancer-promoter interaction
by: Hang Xu, et al.
Published: (2020-01-01)

Association of laxatives use with incident dementia and modifying effect of genetic susceptibility: a population-based cohort study with propensity score matching
by: Jiangtao Feng, et al.
Published: (2023-03-01)

Causal association of obesity with epigenetic aging and telomere length: a bidirectional mendelian randomization study
by: Jixin Li, et al.
Published: (2024-03-01)

Unraveling the associations and causalities between glucose metabolism and multiple sleep traits
by: Minhan Yi, et al.
Published: (2023-11-01)

The causal relationship between genetically determined telomere length and meningiomas risk
by: Weijie Yu, et al.
Published: (2023-08-01)

Unraveling the binding characteristics of small ligands to telomeric DNA by pressure modulation
by: Rosario Oliva, et al.
Published: (2021-05-01)

Alternative Lengthening of Telomeres and Mediated Telomere Synthesis
by: Kailong Hou, et al.
Published: (2022-04-01)

The HeyL-Aromatase Axis Promotes Cancer Stem Cell Properties by Endogenous Estrogen-Induced Autophagy in Castration-Resistant Prostate Cancer
by: Qimei Lin, et al.
Published: (2022-01-01)

Causal relationship between immune cells and telomere length: mendelian randomization analysis
by: Yujian Li, et al.
Published: (2024-03-01)

Unraveling the gut health puzzle: exploring the mechanisms of butyrate and the potential of High-Amylose Maize Starch Butyrate (HAMSB) in alleviating colorectal disturbances
by: Junrui Cheng, et al.
Published: (2024-01-01)

Causal relationships between telomere length and liver disease: a Mendelian randomization study
by: Shuangjing Zhu, et al.
Published: (2023-07-01)

Telomere to Telomere Genome Assembly of Fusarium musae F31, Causal Agent of Crown Rot Disease of Banana
by: Luca Degradi, et al.
Published: (2021-12-01)

No Causal Effect of Telomere Length on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study
by: Weijie Cao, et al.
Published: (2019-02-01)

Unraveling genetic causality between type 2 diabetes and pulmonary tuberculosis on the basis of Mendelian randomization
by: Shengnan Chen, et al.
Published: (2023-11-01)

Causal relationship between telomere length and sepsis: a bidirectional Mendelian randomization study
by: Jiamin Xu, et al.
Published: (2024-03-01)

Unravelling the complex causal effects of substance use behaviours on common diseases
by: Angli Xue, et al.
Published: (2024-03-01)

Causal relationship between atrial fibrillation and leukocyte telomere length: A two sample, bidirectional Mendelian randomization study
by: Zimo Sha, et al.
Published: (2023-02-01)

Maternal antibiotic exposure enhances ILC2 activation in neonates via downregulation of IFN1 signaling
by: Haixu Xu, et al.
Published: (2023-12-01)

Exploring the Causal Pathway From Telomere Length to Alzheimer’s Disease: An Update Mendelian Randomization Study
by: Kai Gao, et al.
Published: (2019-11-01)

Causality of telomere length associated with calcific aortic valvular stenosis: A Mendelian randomization study
by: Junkui Wang, et al.
Published: (2022-12-01)

Causal relationship between telomere length and risk of intracranial aneurysm: a bidirectional Mendelian randomization study
by: Bangjie Xu, et al.
Published: (2024-03-01)

Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells.
by: Lei Yang, et al.
Published: (2013-01-01)

epiCOLOC: Integrating Large-Scale and Context-Dependent Epigenomics Features for Comprehensive Colocalization Analysis
by: Yao Zhou, et al.
Published: (2020-02-01)

Unraveling the causal role of immune cells in gastrointestinal tract cancers: insights from a Mendelian randomization study
by: Yu-xiang Wang, et al.
Published: (2024-03-01)

Causal relationship between telomere length and epilepsy: A bidirectional Mendelian randomization study
by: Xinxin Luo, et al.
Published: (2023-12-01)

Mendelian randomization study on the causal relationship between leukocyte telomere length and prostate cancer.
by: Bangbei Wan, et al.
Published: (2023-01-01)

Coagulation factors and the incidence of COVID-19 severity: Mendelian randomization analyses and supporting evidence
by: Yao Zhou, et al.
Published: (2021-06-01)

3DCoop: An approach for computational inference of cell-type-specific transcriptional regulators cooperation in 3D chromatin
by: Xianfu Yi, et al.
Published: (2022-06-01)

Exploring Causal Relationships between Leukocyte Telomere Length, Sex Hormone‐Binding Globulin Levels, and Osteoporosis Using Univariable and Multivariable Mendelian Randomization
by: Kaibo Sun, et al.
Published: (2024-02-01)

Telomere-to-telomere genome assembly of asparaginase-producing Trichoderma simmonsii
by: Dawoon Chung, et al.
Published: (2021-11-01)

Telomere-to-telomere and haplotype-resolved genome assembly of the Chinese cork oak (Quercus variabilis)
by: Longxin Wang, et al.
Published: (2023-11-01)

Comment on ‘Causal linkage of tobacco smoking with ageing: Mendelian randomization analysis towards telomere attrition and sarcopenia’ by Park et al.
by: Mingchong Liu, et al.
Published: (2023-08-01)

Causal linkage of tobacco smoking with ageing: Mendelian randomization analysis towards telomere attrition and sarcopenia
by: Sehoon Park, et al.
Published: (2023-04-01)

Reverse causal relationship between periodontitis and shortened telomere length: Bidirectional two-sample Mendelian random analysis
by: Jiaxin Hu, et al.
Published: (2022-12-01)

Unraveling how the adolescent brain deals with criticism using dynamic causal modeling
by: Qinyuan Chen, et al.
Published: (2024-02-01)

The causal relationship between thyroid function, autoimune thyroid dysfunction and lung cancer: a mendelian randomization study
by: Xinhui Wang, et al.
Published: (2023-09-01)

First telomere-to-telomere gapless assembly of the rice blast fungus Pyricularia oryzae
by: Zhigang Li, et al.
Published: (2024-04-01)