Role of voltage-gated proton channel (Hv1) in cancer biology
The acid-base characteristics of tumor cells and the other elements that compose the tumor microenvironment have been topics of scientific interest in oncological research. There is much evidence confirming that pH conditions are maintained by changes in the patterns of expression of certain proton...
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| Format: | Article |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1175702/full |
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| author | Juan J. Alvear-Arias Juan J. Alvear-Arias Antonio Pena-Pichicoi Antonio Pena-Pichicoi Christian Carrillo Christian Carrillo Miguel Fernandez Miguel Fernandez Tania Gonzalez Jose A. Garate Jose A. Garate Jose A. Garate Carlos Gonzalez Carlos Gonzalez Carlos Gonzalez |
| author_facet | Juan J. Alvear-Arias Juan J. Alvear-Arias Antonio Pena-Pichicoi Antonio Pena-Pichicoi Christian Carrillo Christian Carrillo Miguel Fernandez Miguel Fernandez Tania Gonzalez Jose A. Garate Jose A. Garate Jose A. Garate Carlos Gonzalez Carlos Gonzalez Carlos Gonzalez |
| author_sort | Juan J. Alvear-Arias |
| collection | DOAJ |
| description | The acid-base characteristics of tumor cells and the other elements that compose the tumor microenvironment have been topics of scientific interest in oncological research. There is much evidence confirming that pH conditions are maintained by changes in the patterns of expression of certain proton transporters. In the past decade, the voltage-gated proton channel (Hv1) has been added to this list and is increasingly being recognized as a target with onco-therapeutic potential. The Hv1 channel is key to proton extrusion for maintaining a balanced cytosolic pH. This protein-channel is expressed in a myriad of tissues and cell lineages whose functions vary from producing bioluminescence in dinoflagellates to alkalizing spermatozoa cytoplasm for reproduction, and regulating the respiratory burst for immune system response. It is no wonder that in acidic environments such as the tumor microenvironment, an exacerbated expression and function of this channel has been reported. Indeed, multiple studies have revealed a strong relationship between pH balance, cancer development, and the overexpression of the Hv1 channel, being proposed as a marker for malignancy in cancer. In this review, we present data that supports the idea that the Hv1 channel plays a significant role in cancer by maintaining pH conditions that favor the development of malignancy features in solid tumor models. With the antecedents presented in this bibliographic report, we want to strengthen the idea that the Hv1 proton channel is an excellent therapeutic strategy to counter the development of solid tumors. |
| first_indexed | 2024-04-09T17:11:54Z |
| format | Article |
| id | doaj.art-cc285a142de9404f86ba4e3dd9e41c72 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-09T17:11:54Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-cc285a142de9404f86ba4e3dd9e41c722023-04-20T05:57:53ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-04-011410.3389/fphar.2023.11757021175702Role of voltage-gated proton channel (Hv1) in cancer biologyJuan J. Alvear-Arias0Juan J. Alvear-Arias1Antonio Pena-Pichicoi2Antonio Pena-Pichicoi3Christian Carrillo4Christian Carrillo5Miguel Fernandez6Miguel Fernandez7Tania Gonzalez8Jose A. Garate9Jose A. Garate10Jose A. Garate11Carlos Gonzalez12Carlos Gonzalez13Carlos Gonzalez14Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso, ChileMillennium Nucleus in NanoBioPhysics, Universidad de Valparaíso, Valparaíso, ChileCentro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso, ChileMillennium Nucleus in NanoBioPhysics, Universidad de Valparaíso, Valparaíso, ChileCentro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso, ChileMillennium Nucleus in NanoBioPhysics, Universidad de Valparaíso, Valparaíso, ChileCentro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso, ChileMillennium Nucleus in NanoBioPhysics, Universidad de Valparaíso, Valparaíso, ChileNational Center for Minimally Invasive Surgery, La Habana, CubaMillennium Nucleus in NanoBioPhysics, Universidad de Valparaíso, Valparaíso, ChileFacultad de Ingeniería y Tecnología, Universidad San Sebastián, Santiago, ChileCentro Científico y Tecnológico de Excelencia Ciencia y Vida, Santiago, ChileCentro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso, ChileMillennium Nucleus in NanoBioPhysics, Universidad de Valparaíso, Valparaíso, ChileDepartment of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, FL, United StatesThe acid-base characteristics of tumor cells and the other elements that compose the tumor microenvironment have been topics of scientific interest in oncological research. There is much evidence confirming that pH conditions are maintained by changes in the patterns of expression of certain proton transporters. In the past decade, the voltage-gated proton channel (Hv1) has been added to this list and is increasingly being recognized as a target with onco-therapeutic potential. The Hv1 channel is key to proton extrusion for maintaining a balanced cytosolic pH. This protein-channel is expressed in a myriad of tissues and cell lineages whose functions vary from producing bioluminescence in dinoflagellates to alkalizing spermatozoa cytoplasm for reproduction, and regulating the respiratory burst for immune system response. It is no wonder that in acidic environments such as the tumor microenvironment, an exacerbated expression and function of this channel has been reported. Indeed, multiple studies have revealed a strong relationship between pH balance, cancer development, and the overexpression of the Hv1 channel, being proposed as a marker for malignancy in cancer. In this review, we present data that supports the idea that the Hv1 channel plays a significant role in cancer by maintaining pH conditions that favor the development of malignancy features in solid tumor models. With the antecedents presented in this bibliographic report, we want to strengthen the idea that the Hv1 proton channel is an excellent therapeutic strategy to counter the development of solid tumors.https://www.frontiersin.org/articles/10.3389/fphar.2023.1175702/fullHv1cancertumorchannelprotonpH |
| spellingShingle | Juan J. Alvear-Arias Juan J. Alvear-Arias Antonio Pena-Pichicoi Antonio Pena-Pichicoi Christian Carrillo Christian Carrillo Miguel Fernandez Miguel Fernandez Tania Gonzalez Jose A. Garate Jose A. Garate Jose A. Garate Carlos Gonzalez Carlos Gonzalez Carlos Gonzalez Role of voltage-gated proton channel (Hv1) in cancer biology Frontiers in Pharmacology Hv1 cancer tumor channel proton pH |
| title | Role of voltage-gated proton channel (Hv1) in cancer biology |
| title_full | Role of voltage-gated proton channel (Hv1) in cancer biology |
| title_fullStr | Role of voltage-gated proton channel (Hv1) in cancer biology |
| title_full_unstemmed | Role of voltage-gated proton channel (Hv1) in cancer biology |
| title_short | Role of voltage-gated proton channel (Hv1) in cancer biology |
| title_sort | role of voltage gated proton channel hv1 in cancer biology |
| topic | Hv1 cancer tumor channel proton pH |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1175702/full |
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