The effect of 12 weeks of combined training on hepatic fat content and metabolic flexibility of individuals with non-alcoholic fatty liver disease: Protocol of an open-label, single-center randomized control trial
IntroductionMetabolic flexibility (MetF) is the capacity of an organism to oxidate substrate according to substrate availability or demand. The mismatch of substrate availability and oxidation may cause ectopic fat accumulation in the muscle and the liver. The objectives of the study are to examine...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1065188/full |
| _version_ | 1797952103180664832 |
|---|---|
| author | Wei Huang Wei Huang Weiqi Ruan Weiqi Ruan Cuilan Huo Yanyu Lin Yanyu Lin Tian Wang Tian Wang Xiangdi Dai Xiangdi Dai Haonan Zhai Jiasheng Ma Jingyi Zhang Jingyi Zhang Jin Lu Jie Zhuang Jie Zhuang |
| author_facet | Wei Huang Wei Huang Weiqi Ruan Weiqi Ruan Cuilan Huo Yanyu Lin Yanyu Lin Tian Wang Tian Wang Xiangdi Dai Xiangdi Dai Haonan Zhai Jiasheng Ma Jingyi Zhang Jingyi Zhang Jin Lu Jie Zhuang Jie Zhuang |
| author_sort | Wei Huang |
| collection | DOAJ |
| description | IntroductionMetabolic flexibility (MetF) is the capacity of an organism to oxidate substrate according to substrate availability or demand. The mismatch of substrate availability and oxidation may cause ectopic fat accumulation in the muscle and the liver. The objectives of the study are to examine the effect of 12 weeks of combined exercise on hepatic fat reduction and investigate metabolites related to MetF before and after the high-fat diet between individuals with NAFLD and healthy control with an active lifestyle.MethodsThis study is an open-label, single-center trial randomized controlled clinical study plus a cross-sectional comparison between individuals with NAFLD and healthy control. Individuals with NAFLD were allocated into two groups receiving resistance training (RT) combined with high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT). Anthropometric indicators, clinical blood markers about glucose, lipid metabolism, and hepatic fat content (HFC) were assessed before and after the intervention. The metabolomics was also used to investigate the discrepant metabolites and mechanisms related to MetF.DiscussionMetabolic flexibility reflects the capacity of an organism to switch the oxidation substrates flexibly, which is associated with ectopic fat accumulation. Our study aimed to explore the discrepant metabolites related to MetF before and after a high-fat diet between individuals with NAFLD and healthy control. In addition, the study also examined the effectiveness of RT combined with HIIT or MICT on hepatic fat reduction and quantificationally analyzed the metabolites related to MetF before and after the intervention. Our results provided a perspective on fatty liver-associated metabolic inactivity.Trial registrationClinicalTrials.gov: ChiCTR2200055110; Registered 31 December 2021, http://www.chictr.org.cn/index.aspx. |
| first_indexed | 2024-04-10T22:42:08Z |
| format | Article |
| id | doaj.art-cc294e4ce20e4c69945e870dcc65870b |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T22:42:08Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-cc294e4ce20e4c69945e870dcc65870b2023-01-16T04:44:00ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-01-01910.3389/fnut.2022.10651881065188The effect of 12 weeks of combined training on hepatic fat content and metabolic flexibility of individuals with non-alcoholic fatty liver disease: Protocol of an open-label, single-center randomized control trialWei Huang0Wei Huang1Weiqi Ruan2Weiqi Ruan3Cuilan Huo4Yanyu Lin5Yanyu Lin6Tian Wang7Tian Wang8Xiangdi Dai9Xiangdi Dai10Haonan Zhai11Jiasheng Ma12Jingyi Zhang13Jingyi Zhang14Jin Lu15Jie Zhuang16Jie Zhuang17Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaShanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaDepartment of Endocrinology, The First Affiliated Hospital of the Naval Medical University, Shanghai, ChinaShanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaShanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaShanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaSchool of Physical Education, Shanghai University of Sport, Shanghai, ChinaSchool of Elite Sport, Shanghai University of Sport, Shanghai, ChinaShanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaDepartment of Endocrinology, The First Affiliated Hospital of the Naval Medical University, Shanghai, ChinaShanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaIntroductionMetabolic flexibility (MetF) is the capacity of an organism to oxidate substrate according to substrate availability or demand. The mismatch of substrate availability and oxidation may cause ectopic fat accumulation in the muscle and the liver. The objectives of the study are to examine the effect of 12 weeks of combined exercise on hepatic fat reduction and investigate metabolites related to MetF before and after the high-fat diet between individuals with NAFLD and healthy control with an active lifestyle.MethodsThis study is an open-label, single-center trial randomized controlled clinical study plus a cross-sectional comparison between individuals with NAFLD and healthy control. Individuals with NAFLD were allocated into two groups receiving resistance training (RT) combined with high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT). Anthropometric indicators, clinical blood markers about glucose, lipid metabolism, and hepatic fat content (HFC) were assessed before and after the intervention. The metabolomics was also used to investigate the discrepant metabolites and mechanisms related to MetF.DiscussionMetabolic flexibility reflects the capacity of an organism to switch the oxidation substrates flexibly, which is associated with ectopic fat accumulation. Our study aimed to explore the discrepant metabolites related to MetF before and after a high-fat diet between individuals with NAFLD and healthy control. In addition, the study also examined the effectiveness of RT combined with HIIT or MICT on hepatic fat reduction and quantificationally analyzed the metabolites related to MetF before and after the intervention. Our results provided a perspective on fatty liver-associated metabolic inactivity.Trial registrationClinicalTrials.gov: ChiCTR2200055110; Registered 31 December 2021, http://www.chictr.org.cn/index.aspx.https://www.frontiersin.org/articles/10.3389/fnut.2022.1065188/fullNAFLDmetabolic flexibilityexercise interventioncombined trainingrandomized controlled trialhepatic fat content |
| spellingShingle | Wei Huang Wei Huang Weiqi Ruan Weiqi Ruan Cuilan Huo Yanyu Lin Yanyu Lin Tian Wang Tian Wang Xiangdi Dai Xiangdi Dai Haonan Zhai Jiasheng Ma Jingyi Zhang Jingyi Zhang Jin Lu Jie Zhuang Jie Zhuang The effect of 12 weeks of combined training on hepatic fat content and metabolic flexibility of individuals with non-alcoholic fatty liver disease: Protocol of an open-label, single-center randomized control trial Frontiers in Nutrition NAFLD metabolic flexibility exercise intervention combined training randomized controlled trial hepatic fat content |
| title | The effect of 12 weeks of combined training on hepatic fat content and metabolic flexibility of individuals with non-alcoholic fatty liver disease: Protocol of an open-label, single-center randomized control trial |
| title_full | The effect of 12 weeks of combined training on hepatic fat content and metabolic flexibility of individuals with non-alcoholic fatty liver disease: Protocol of an open-label, single-center randomized control trial |
| title_fullStr | The effect of 12 weeks of combined training on hepatic fat content and metabolic flexibility of individuals with non-alcoholic fatty liver disease: Protocol of an open-label, single-center randomized control trial |
| title_full_unstemmed | The effect of 12 weeks of combined training on hepatic fat content and metabolic flexibility of individuals with non-alcoholic fatty liver disease: Protocol of an open-label, single-center randomized control trial |
| title_short | The effect of 12 weeks of combined training on hepatic fat content and metabolic flexibility of individuals with non-alcoholic fatty liver disease: Protocol of an open-label, single-center randomized control trial |
| title_sort | effect of 12 weeks of combined training on hepatic fat content and metabolic flexibility of individuals with non alcoholic fatty liver disease protocol of an open label single center randomized control trial |
| topic | NAFLD metabolic flexibility exercise intervention combined training randomized controlled trial hepatic fat content |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1065188/full |
| work_keys_str_mv | AT weihuang theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT weihuang theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT weiqiruan theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT weiqiruan theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT cuilanhuo theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT yanyulin theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT yanyulin theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT tianwang theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT tianwang theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT xiangdidai theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT xiangdidai theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT haonanzhai theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT jiashengma theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT jingyizhang theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT jingyizhang theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT jinlu theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT jiezhuang theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT jiezhuang theeffectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT weihuang effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT weihuang effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT weiqiruan effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT weiqiruan effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT cuilanhuo effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT yanyulin effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT yanyulin effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT tianwang effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT tianwang effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT xiangdidai effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT xiangdidai effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT haonanzhai effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT jiashengma effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT jingyizhang effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT jingyizhang effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT jinlu effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT jiezhuang effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial AT jiezhuang effectof12weeksofcombinedtrainingonhepaticfatcontentandmetabolicflexibilityofindividualswithnonalcoholicfattyliverdiseaseprotocolofanopenlabelsinglecenterrandomizedcontroltrial |