Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands
The molecular mechanisms underlying retrograde transport in axons are only partially understood. Villarinet al. show that in cultured DRG neurons, extracellular trophic cues such as NGF dynamically regulate local protein synthesis of dynein cofactors, thus controlling retrograde trafficking in neuro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13865 |