PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis in gastric cancer
Gastric cancer (GC) is a major health burden worldwide, but our understanding of GC is limited, and the prognosis is poor. Novel therapeutic strategies and biomarkers are urgently needed to improve GC patient outcomes. Previously, we identified PFDN2 as a novel key gene in gastric cancer based on it...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1164070/full |
| _version_ | 1797777662304845824 |
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| author | Qiuming He Qiuming He Qiuming He Zheyu Ding Zheyu Ding Tingna Chen Tingna Chen Haitao Wu Jialing Song Jialing Song Zhenxian Xiang Zhenxian Xiang Chaogang Yang Chaogang Yang Shuyi Wang Shuyi Wang Bin Xiong Bin Xiong |
| author_facet | Qiuming He Qiuming He Qiuming He Zheyu Ding Zheyu Ding Tingna Chen Tingna Chen Haitao Wu Jialing Song Jialing Song Zhenxian Xiang Zhenxian Xiang Chaogang Yang Chaogang Yang Shuyi Wang Shuyi Wang Bin Xiong Bin Xiong |
| author_sort | Qiuming He |
| collection | DOAJ |
| description | Gastric cancer (GC) is a major health burden worldwide, but our understanding of GC is limited, and the prognosis is poor. Novel therapeutic strategies and biomarkers are urgently needed to improve GC patient outcomes. Previously, we identified PFDN2 as a novel key gene in gastric cancer based on its differential expression between cancer and normal tissues. However, the role and underlying mechanisms of PFDN2 in GC remain elusive. In this article, we demonstrated that PFDN2 is highly expressed in GC and that upregulation of PFDN2 is associated with the progression of GC. We further found that PFDN2 could promote cell cycle progression by promoting MYBL2 expression. Mechanistically, we demonstrated that PFDN2 could upregulate MYBL2 expression by facilitating the nuclear translocation of hnRNPD, and thus promoting MYBL2 transcriptional program. In conclusion, we found that PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis and may serve as a potential biomarker and therapeutic target for GC. |
| first_indexed | 2024-03-12T23:07:01Z |
| format | Article |
| id | doaj.art-cc2d598a461d462fa62d1be3187959ed |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-12T23:07:01Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-cc2d598a461d462fa62d1be3187959ed2023-07-18T15:37:48ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-07-011310.3389/fonc.2023.11640701164070PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis in gastric cancerQiuming He0Qiuming He1Qiuming He2Zheyu Ding3Zheyu Ding4Tingna Chen5Tingna Chen6Haitao Wu7Jialing Song8Jialing Song9Zhenxian Xiang10Zhenxian Xiang11Chaogang Yang12Chaogang Yang13Shuyi Wang14Shuyi Wang15Bin Xiong16Bin Xiong17Department of Gastrointestinal Surgery & Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Tumor Biological Behaviors, Wuhan, ChinaDepartment of Gastrointestinal Surgery & Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Tumor Biological Behaviors, Wuhan, ChinaDepartment of Gastrointestinal Surgery & Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Tumor Biological Behaviors, Wuhan, ChinaDepartment of Thyroid and Breast Surgery, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Gastrointestinal Surgery & Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Tumor Biological Behaviors, Wuhan, ChinaDepartment of Gastrointestinal Surgery & Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Tumor Biological Behaviors, Wuhan, ChinaDepartment of Gastrointestinal Surgery & Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Tumor Biological Behaviors, Wuhan, ChinaDepartment of Gastrointestinal Surgery & Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Tumor Biological Behaviors, Wuhan, ChinaDepartment of Gastrointestinal Surgery & Department of Gastric and Colorectal Surgical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Tumor Biological Behaviors, Wuhan, ChinaGastric cancer (GC) is a major health burden worldwide, but our understanding of GC is limited, and the prognosis is poor. Novel therapeutic strategies and biomarkers are urgently needed to improve GC patient outcomes. Previously, we identified PFDN2 as a novel key gene in gastric cancer based on its differential expression between cancer and normal tissues. However, the role and underlying mechanisms of PFDN2 in GC remain elusive. In this article, we demonstrated that PFDN2 is highly expressed in GC and that upregulation of PFDN2 is associated with the progression of GC. We further found that PFDN2 could promote cell cycle progression by promoting MYBL2 expression. Mechanistically, we demonstrated that PFDN2 could upregulate MYBL2 expression by facilitating the nuclear translocation of hnRNPD, and thus promoting MYBL2 transcriptional program. In conclusion, we found that PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis and may serve as a potential biomarker and therapeutic target for GC.https://www.frontiersin.org/articles/10.3389/fonc.2023.1164070/fullPFDN2Cell CycleMYBL2gastric cancerHNRNPD |
| spellingShingle | Qiuming He Qiuming He Qiuming He Zheyu Ding Zheyu Ding Tingna Chen Tingna Chen Haitao Wu Jialing Song Jialing Song Zhenxian Xiang Zhenxian Xiang Chaogang Yang Chaogang Yang Shuyi Wang Shuyi Wang Bin Xiong Bin Xiong PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis in gastric cancer Frontiers in Oncology PFDN2 Cell Cycle MYBL2 gastric cancer HNRNPD |
| title | PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis in gastric cancer |
| title_full | PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis in gastric cancer |
| title_fullStr | PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis in gastric cancer |
| title_full_unstemmed | PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis in gastric cancer |
| title_short | PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis in gastric cancer |
| title_sort | pfdn2 promotes cell cycle progression via the hnrnpd mybl2 axis in gastric cancer |
| topic | PFDN2 Cell Cycle MYBL2 gastric cancer HNRNPD |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1164070/full |
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