A multicentre review comparing long term outcomes of endoscopic vein harvesting versus open vein harvesting for coronary artery bypass surgery [version 1; peer review: 1 approved, 2 approved with reservations]
Background: Utilisation of the Endoscopic Vein Harvesting (EVH) technique has been increasing for coronary artery bypass grafting (CABG) for the last two decades. Some surgeons remain concerned about the long-term patency of the long saphenous vein harvested endoscopically compared to traditional Op...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2021-07-01
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| Series: | NIHR Open Research |
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| Online Access: | https://openresearch.nihr.ac.uk/articles/1-11/v1 |
| _version_ | 1797847588494376960 |
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| author | Bhuvaneswari Krishnamoorthy William R. Critchley Joesph Zacharias Iryna Stalpinskaya Melissa Rochon Rajamiyer V. Venkateswaran Azita Rajai Toufan Bahrami Shahzad G. Raja |
| author_facet | Bhuvaneswari Krishnamoorthy William R. Critchley Joesph Zacharias Iryna Stalpinskaya Melissa Rochon Rajamiyer V. Venkateswaran Azita Rajai Toufan Bahrami Shahzad G. Raja |
| author_sort | Bhuvaneswari Krishnamoorthy |
| collection | DOAJ |
| description | Background: Utilisation of the Endoscopic Vein Harvesting (EVH) technique has been increasing for coronary artery bypass grafting (CABG) for the last two decades. Some surgeons remain concerned about the long-term patency of the long saphenous vein harvested endoscopically compared to traditional Open Vein Harvesting (OVH). The aim of this study was to perform a retrospective analysis of the outcomes between EVH and OVH from three UK centres with 10 years follow-up. Methods: 27,024 patients underwent CABG with long saphenous vein harvested by EVH (n=13,794) or OVH (n=13,230) in three UK centres between 2007 and 2019. Propensity modelling was used to calculate the Inverse Probability of Treatment Weights (IPTW). The primary endpoint was mortality from all causes and secondary endpoints were length of hospital stay, postoperative complications, and incidence of repeat coronary re-vascularisation for symptomatic patients. IPTW was used to balance the two intervention groups for baseline and preoperative co-morbidities. Results: Median follow-up time was 4.54 years for EVH and 6.00 years for OVH. Death from any cause occurred in 13.8% of the EVH group versus 20.8% in the OVH group over the follow-up period. The hazard ratio of death (EVH to OVH) was 0.823 (95% CI: 0.767, 0.884). Length of hospital stay was similar between the groups (p=0.86). Post-operative pulmonary complications were more common in EVH vs OVH (14.7% vs. 12.8%, p<0.001), but repeat coronary re-vascularisation was similar between the groups. Conclusion: This large retrospective multicentre analysis indicates that EVH has a lower risk of mortality compared with OVH during the follow-up period of the study. The observed benefits of EVH may outweigh the risks but should be considered on a case-by-case basis. We hope this review gives confidence to other cardiac centres that offering an EVH approach to conduit harvesting does not affect long term patient outcomes. |
| first_indexed | 2024-04-09T18:13:53Z |
| format | Article |
| id | doaj.art-cc30f9a3967a4acd890706fefd237b76 |
| institution | Directory Open Access Journal |
| issn | 2633-4402 |
| language | English |
| last_indexed | 2024-04-09T18:13:53Z |
| publishDate | 2021-07-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | NIHR Open Research |
| spelling | doaj.art-cc30f9a3967a4acd890706fefd237b762023-04-13T11:02:08ZengF1000 Research LtdNIHR Open Research2633-44022021-07-01114331A multicentre review comparing long term outcomes of endoscopic vein harvesting versus open vein harvesting for coronary artery bypass surgery [version 1; peer review: 1 approved, 2 approved with reservations]Bhuvaneswari Krishnamoorthy0https://orcid.org/0000-0001-5250-1104William R. Critchley1Joesph Zacharias2Iryna Stalpinskaya3Melissa Rochon4https://orcid.org/0000-0002-1101-2256Rajamiyer V. Venkateswaran5Azita Rajai6https://orcid.org/0000-0002-0376-9945Toufan Bahrami7Shahzad G. Raja8Department of Allied Health Professions, Faculty of Health and Social Service, Edge hill University, Ormskirk, UKEndothelial Cell Biology, School of Molecular Medicine, University of Leeds, Leeds, England, UKDepartment of Cardiothoracic surgery, Blackpool Victoria NHS trust, Blackpool, UKDepartment of Cardiothoracic surgery, Blackpool Victoria NHS trust, Blackpool, UKDepartment of Cardiothoracic surgery, Royal Brompton & Harefield NHS Trust, London, UKDepartment of Allied Health Professions, Faculty of Health and Social Service, Edge hill University, Ormskirk, UKCentre for Biostatitics, Division of Population Health, University of Manchester, Manchester, UKDepartment of Cardiothoracic surgery, Royal Brompton & Harefield NHS Trust, London, UKDepartment of Cardiothoracic surgery, Royal Brompton & Harefield NHS Trust, London, UKBackground: Utilisation of the Endoscopic Vein Harvesting (EVH) technique has been increasing for coronary artery bypass grafting (CABG) for the last two decades. Some surgeons remain concerned about the long-term patency of the long saphenous vein harvested endoscopically compared to traditional Open Vein Harvesting (OVH). The aim of this study was to perform a retrospective analysis of the outcomes between EVH and OVH from three UK centres with 10 years follow-up. Methods: 27,024 patients underwent CABG with long saphenous vein harvested by EVH (n=13,794) or OVH (n=13,230) in three UK centres between 2007 and 2019. Propensity modelling was used to calculate the Inverse Probability of Treatment Weights (IPTW). The primary endpoint was mortality from all causes and secondary endpoints were length of hospital stay, postoperative complications, and incidence of repeat coronary re-vascularisation for symptomatic patients. IPTW was used to balance the two intervention groups for baseline and preoperative co-morbidities. Results: Median follow-up time was 4.54 years for EVH and 6.00 years for OVH. Death from any cause occurred in 13.8% of the EVH group versus 20.8% in the OVH group over the follow-up period. The hazard ratio of death (EVH to OVH) was 0.823 (95% CI: 0.767, 0.884). Length of hospital stay was similar between the groups (p=0.86). Post-operative pulmonary complications were more common in EVH vs OVH (14.7% vs. 12.8%, p<0.001), but repeat coronary re-vascularisation was similar between the groups. Conclusion: This large retrospective multicentre analysis indicates that EVH has a lower risk of mortality compared with OVH during the follow-up period of the study. The observed benefits of EVH may outweigh the risks but should be considered on a case-by-case basis. We hope this review gives confidence to other cardiac centres that offering an EVH approach to conduit harvesting does not affect long term patient outcomes.https://openresearch.nihr.ac.uk/articles/1-11/v1Open vein harvesting survival endoscopic vein harvesting major adverse cardiac events coronary artery bypass graft clinical outcomes.eng |
| spellingShingle | Bhuvaneswari Krishnamoorthy William R. Critchley Joesph Zacharias Iryna Stalpinskaya Melissa Rochon Rajamiyer V. Venkateswaran Azita Rajai Toufan Bahrami Shahzad G. Raja A multicentre review comparing long term outcomes of endoscopic vein harvesting versus open vein harvesting for coronary artery bypass surgery [version 1; peer review: 1 approved, 2 approved with reservations] NIHR Open Research Open vein harvesting survival endoscopic vein harvesting major adverse cardiac events coronary artery bypass graft clinical outcomes. eng |
| title | A multicentre review comparing long term outcomes of endoscopic vein harvesting versus open vein harvesting for coronary artery bypass surgery [version 1; peer review: 1 approved, 2 approved with reservations] |
| title_full | A multicentre review comparing long term outcomes of endoscopic vein harvesting versus open vein harvesting for coronary artery bypass surgery [version 1; peer review: 1 approved, 2 approved with reservations] |
| title_fullStr | A multicentre review comparing long term outcomes of endoscopic vein harvesting versus open vein harvesting for coronary artery bypass surgery [version 1; peer review: 1 approved, 2 approved with reservations] |
| title_full_unstemmed | A multicentre review comparing long term outcomes of endoscopic vein harvesting versus open vein harvesting for coronary artery bypass surgery [version 1; peer review: 1 approved, 2 approved with reservations] |
| title_short | A multicentre review comparing long term outcomes of endoscopic vein harvesting versus open vein harvesting for coronary artery bypass surgery [version 1; peer review: 1 approved, 2 approved with reservations] |
| title_sort | multicentre review comparing long term outcomes of endoscopic vein harvesting versus open vein harvesting for coronary artery bypass surgery version 1 peer review 1 approved 2 approved with reservations |
| topic | Open vein harvesting survival endoscopic vein harvesting major adverse cardiac events coronary artery bypass graft clinical outcomes. eng |
| url | https://openresearch.nihr.ac.uk/articles/1-11/v1 |
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