Cortical plasticity is correlated with cognitive improvement in Alzheimer’s disease patients after rTMS treatment
Objective: Repetitive transcranial magnetic stimulation (rTMS) has been widely used in non-invasive treatments for different neurological disorders. Few biomarkers are available for treatment response prediction. This study aims to analyze the correlation between changes in long-term potentiation (L...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-05-01
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| Series: | Brain Stimulation |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X21000176 |
| _version_ | 1819047220063764480 |
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| author | Xingxing Li Gangqiao Qi Chang Yu Guomin Lian Hong Zheng Shaochang Wu Ti-Fei Yuan Dongsheng Zhou |
| author_facet | Xingxing Li Gangqiao Qi Chang Yu Guomin Lian Hong Zheng Shaochang Wu Ti-Fei Yuan Dongsheng Zhou |
| author_sort | Xingxing Li |
| collection | DOAJ |
| description | Objective: Repetitive transcranial magnetic stimulation (rTMS) has been widely used in non-invasive treatments for different neurological disorders. Few biomarkers are available for treatment response prediction. This study aims to analyze the correlation between changes in long-term potentiation (LTP)-like cortical plasticity and cognitive function in patients with Alzheimer’s disease (AD) that underwent rTMS treatment. Methods: A total of 75 AD patients were randomized into either 20 Hz rTMS treatment at the dorsolateral prefrontal cortex (DLPFC) group (n = 37) or a sham treatment group (n = 38) for 30 sessions over six weeks (five days per week) with a three-month follow-up. Neuropsychological assessments were conducted using the Mini-Mental State Examination (MMSE) and Alzheimer’s Disease Assessment-Cognitive Component (ADAS-Cog). The cortical plasticity reflected by the motor-evoked potential (MEP) before and after high-frequency repetitive TMS to the primary motor cortex (M1) was also examined prior to and after the treatment period. Results: The results showed that the cognitive ability of patients who underwent the MMSE and ADAS-Cog assessments showed small but significant improvement after six weeks of rTMS treatment compared with the sham group. The cortical plasticity improvement correlated to the observed cognition change. Conclusions: Cortical LTP-like plasticity could predict the treatment responses of cognitive improvements in AD patients receiving rTMS intervention. This warrants future clinical trials using cortical LTP as a predictive marker. |
| first_indexed | 2024-12-21T10:56:54Z |
| format | Article |
| id | doaj.art-cc31c67db0234fa1aae2213e94255b21 |
| institution | Directory Open Access Journal |
| issn | 1935-861X |
| language | English |
| last_indexed | 2024-12-21T10:56:54Z |
| publishDate | 2021-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Stimulation |
| spelling | doaj.art-cc31c67db0234fa1aae2213e94255b212022-12-21T19:06:29ZengElsevierBrain Stimulation1935-861X2021-05-01143503510Cortical plasticity is correlated with cognitive improvement in Alzheimer’s disease patients after rTMS treatmentXingxing Li0Gangqiao Qi1Chang Yu2Guomin Lian3Hong Zheng4Shaochang Wu5Ti-Fei Yuan6Dongsheng Zhou7Ningbo Kangning Hospital, Ningbo, Zhejiang, ChinaTaizhou Second People’s Hospital, Taizhou, Zhejiang, ChinaNingbo Kangning Hospital, Ningbo, Zhejiang, ChinaNingbo Kangning Hospital, Ningbo, Zhejiang, ChinaNingbo Kangning Hospital, Ningbo, Zhejiang, ChinaThe Second People’s Hospital of Lishui, Lishui, Zhejiang, China; Corresponding author.Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China; Corresponding author. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Ningbo Kangning Hospital, Ningbo, Zhejiang, China; Corresponding author. Ningbo Kangning Hospital, Ningbo Key Laboratory of Sleep Medicine, Ningbo, Zhejiang, China.Objective: Repetitive transcranial magnetic stimulation (rTMS) has been widely used in non-invasive treatments for different neurological disorders. Few biomarkers are available for treatment response prediction. This study aims to analyze the correlation between changes in long-term potentiation (LTP)-like cortical plasticity and cognitive function in patients with Alzheimer’s disease (AD) that underwent rTMS treatment. Methods: A total of 75 AD patients were randomized into either 20 Hz rTMS treatment at the dorsolateral prefrontal cortex (DLPFC) group (n = 37) or a sham treatment group (n = 38) for 30 sessions over six weeks (five days per week) with a three-month follow-up. Neuropsychological assessments were conducted using the Mini-Mental State Examination (MMSE) and Alzheimer’s Disease Assessment-Cognitive Component (ADAS-Cog). The cortical plasticity reflected by the motor-evoked potential (MEP) before and after high-frequency repetitive TMS to the primary motor cortex (M1) was also examined prior to and after the treatment period. Results: The results showed that the cognitive ability of patients who underwent the MMSE and ADAS-Cog assessments showed small but significant improvement after six weeks of rTMS treatment compared with the sham group. The cortical plasticity improvement correlated to the observed cognition change. Conclusions: Cortical LTP-like plasticity could predict the treatment responses of cognitive improvements in AD patients receiving rTMS intervention. This warrants future clinical trials using cortical LTP as a predictive marker.http://www.sciencedirect.com/science/article/pii/S1935861X21000176rTMSTranscranial magnetic stimulationAlzheimer’s diseaseCognitionCortical plasticityLong-term potentiation |
| spellingShingle | Xingxing Li Gangqiao Qi Chang Yu Guomin Lian Hong Zheng Shaochang Wu Ti-Fei Yuan Dongsheng Zhou Cortical plasticity is correlated with cognitive improvement in Alzheimer’s disease patients after rTMS treatment Brain Stimulation rTMS Transcranial magnetic stimulation Alzheimer’s disease Cognition Cortical plasticity Long-term potentiation |
| title | Cortical plasticity is correlated with cognitive improvement in Alzheimer’s disease patients after rTMS treatment |
| title_full | Cortical plasticity is correlated with cognitive improvement in Alzheimer’s disease patients after rTMS treatment |
| title_fullStr | Cortical plasticity is correlated with cognitive improvement in Alzheimer’s disease patients after rTMS treatment |
| title_full_unstemmed | Cortical plasticity is correlated with cognitive improvement in Alzheimer’s disease patients after rTMS treatment |
| title_short | Cortical plasticity is correlated with cognitive improvement in Alzheimer’s disease patients after rTMS treatment |
| title_sort | cortical plasticity is correlated with cognitive improvement in alzheimer s disease patients after rtms treatment |
| topic | rTMS Transcranial magnetic stimulation Alzheimer’s disease Cognition Cortical plasticity Long-term potentiation |
| url | http://www.sciencedirect.com/science/article/pii/S1935861X21000176 |
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