How useful are ferric chloride models of arterial thrombosis?
The ferric chloride models of arterial thrombosis are useful tools with which to investigate the cellular and molecular mechanisms that contribute to arterial thrombosis. Recent insights have, however, revealed the complex and multifaceted mechanism by which ferric chloride induces thrombus formatio...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-05-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2019.1678119 |
| _version_ | 1797684224969408512 |
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| author | Steven P. Grover Nigel Mackman |
| author_facet | Steven P. Grover Nigel Mackman |
| author_sort | Steven P. Grover |
| collection | DOAJ |
| description | The ferric chloride models of arterial thrombosis are useful tools with which to investigate the cellular and molecular mechanisms that contribute to arterial thrombosis. Recent insights have, however, revealed the complex and multifaceted mechanism by which ferric chloride induces thrombus formation. Here, we discuss the strengths and weaknesses of the ferric chloride models of arterial thrombosis. Particular focus is given to the phenotypes of different knockout mice in the ferric chloride models and how these compare to other models with independent modes of initiation. Further, we discuss the relevance of the ferric chloride models to the human pathology of atherothrombotic disease. |
| first_indexed | 2024-03-12T00:26:35Z |
| format | Article |
| id | doaj.art-cc32b2e882e24ea5992de4f8c2348beb |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:26:35Z |
| publishDate | 2020-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-cc32b2e882e24ea5992de4f8c2348beb2023-09-15T10:32:02ZengTaylor & Francis GroupPlatelets0953-71041369-16352020-05-0131443243810.1080/09537104.2019.16781191678119How useful are ferric chloride models of arterial thrombosis?Steven P. Grover0Nigel Mackman1University of North Carolina at Chapel HillUniversity of North Carolina at Chapel HillThe ferric chloride models of arterial thrombosis are useful tools with which to investigate the cellular and molecular mechanisms that contribute to arterial thrombosis. Recent insights have, however, revealed the complex and multifaceted mechanism by which ferric chloride induces thrombus formation. Here, we discuss the strengths and weaknesses of the ferric chloride models of arterial thrombosis. Particular focus is given to the phenotypes of different knockout mice in the ferric chloride models and how these compare to other models with independent modes of initiation. Further, we discuss the relevance of the ferric chloride models to the human pathology of atherothrombotic disease.http://dx.doi.org/10.1080/09537104.2019.1678119animal modelserythrocytesferric chlorideplateletsthrombosis |
| spellingShingle | Steven P. Grover Nigel Mackman How useful are ferric chloride models of arterial thrombosis? Platelets animal models erythrocytes ferric chloride platelets thrombosis |
| title | How useful are ferric chloride models of arterial thrombosis? |
| title_full | How useful are ferric chloride models of arterial thrombosis? |
| title_fullStr | How useful are ferric chloride models of arterial thrombosis? |
| title_full_unstemmed | How useful are ferric chloride models of arterial thrombosis? |
| title_short | How useful are ferric chloride models of arterial thrombosis? |
| title_sort | how useful are ferric chloride models of arterial thrombosis |
| topic | animal models erythrocytes ferric chloride platelets thrombosis |
| url | http://dx.doi.org/10.1080/09537104.2019.1678119 |
| work_keys_str_mv | AT stevenpgrover howusefulareferricchloridemodelsofarterialthrombosis AT nigelmackman howusefulareferricchloridemodelsofarterialthrombosis |