Pioglitazone Eases Testicular Torsion/Detorsion-Induced Ischemia- Reperfusion Injury in Rats
Objective:This study demonstrated the protective effects of pioglitazone (Pio) on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury.Materials and Methods:A total of 48 male rats were randomly divided into six experimental groups of eight rats each; Control group, I/R group, Pio...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2023-06-01
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| Series: | Journal of Urological Surgery |
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http://jurolsurgery.org/archives/archive-detail/article-preview/pioglitazone-eases-testicular-torsion-detorsion-nd/60541
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| author | İrfan Yıldırım Şentürk Müslim Doğan Değer Muhammed Ali Aydın Serdar Madendere Oktay Kaya Ebru Taştekin Tevfik Aktoz |
| author_facet | İrfan Yıldırım Şentürk Müslim Doğan Değer Muhammed Ali Aydın Serdar Madendere Oktay Kaya Ebru Taştekin Tevfik Aktoz |
| author_sort | İrfan Yıldırım Şentürk |
| collection | DOAJ |
| description | Objective:This study demonstrated the protective effects of pioglitazone (Pio) on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury.Materials and Methods:A total of 48 male rats were randomly divided into six experimental groups of eight rats each; Control group, I/R group, Pio 3 mg/kg group, I/R treated with Pio 3 mg/kg group, Pio 6 mg/kg group, and I/R treated with Pio 6 mg/kg group. Testicular torsion was induced by twisting the left testis 720 °C in a clockwise direction (I/R groups). Both ischemia and reperfusion periods were 4 h. Single-dose 3 mg/kg Pio or 6 mg/kg Pio was administered orally two hours before reperfusion (Pio groups). Left orchiectomy was performed at the end of the protocol.Results:In the I/R within-group analysis for mean seminiferous tubule diameter and epithelial lengths, a statistically significant difference was found only in the Pio 6 group (p=0.005; p=0.005). But Pio treatment failed to improve the levels of malondialdehyde and glutathione. Also, it did not cause any change in the non-I/R groups.Conclusion:Considering the findings of Pio, it may be used in emergencies such as torsion and other chronic diseases. |
| first_indexed | 2024-03-13T06:57:16Z |
| format | Article |
| id | doaj.art-cc33287054a34563b4c52190de8c04c6 |
| institution | Directory Open Access Journal |
| issn | 2148-9580 |
| language | English |
| last_indexed | 2024-03-13T06:57:16Z |
| publishDate | 2023-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Urological Surgery |
| spelling | doaj.art-cc33287054a34563b4c52190de8c04c62023-06-07T06:57:08ZengGalenos YayineviJournal of Urological Surgery2148-95802023-06-0110216717210.4274/jus.galenos.2022.2022.004713049054Pioglitazone Eases Testicular Torsion/Detorsion-Induced Ischemia- Reperfusion Injury in Ratsİrfan Yıldırım Şentürk0Müslim Doğan Değer1Muhammed Ali Aydın2Serdar Madendere3Oktay Kaya4Ebru Taştekin5Tevfik Aktoz6 Trakya University Faculty of Medicine, Department of Urology, Edirne, Turkiye Trakya University Faculty of Medicine, Department of Urology, Edirne, Turkiye Trakya University Faculty of Medicine, Department of Physiology, Edirne, Turkiye Trakya University Faculty of Medicine, Department of Urology, Edirne, Turkiye Trakya University Faculty of Medicine, Department of Physiology, Edirne, Turkiye Trakya University Faculty of Medicine, Department of Pathology, Edirne, Turkiye Trakya University Faculty of Medicine, Department of Urology, Edirne, Turkiye Objective:This study demonstrated the protective effects of pioglitazone (Pio) on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury.Materials and Methods:A total of 48 male rats were randomly divided into six experimental groups of eight rats each; Control group, I/R group, Pio 3 mg/kg group, I/R treated with Pio 3 mg/kg group, Pio 6 mg/kg group, and I/R treated with Pio 6 mg/kg group. Testicular torsion was induced by twisting the left testis 720 °C in a clockwise direction (I/R groups). Both ischemia and reperfusion periods were 4 h. Single-dose 3 mg/kg Pio or 6 mg/kg Pio was administered orally two hours before reperfusion (Pio groups). Left orchiectomy was performed at the end of the protocol.Results:In the I/R within-group analysis for mean seminiferous tubule diameter and epithelial lengths, a statistically significant difference was found only in the Pio 6 group (p=0.005; p=0.005). But Pio treatment failed to improve the levels of malondialdehyde and glutathione. Also, it did not cause any change in the non-I/R groups.Conclusion:Considering the findings of Pio, it may be used in emergencies such as torsion and other chronic diseases. http://jurolsurgery.org/archives/archive-detail/article-preview/pioglitazone-eases-testicular-torsion-detorsion-nd/60541 testicular torsionischemiareperfusion |
| spellingShingle | İrfan Yıldırım Şentürk Müslim Doğan Değer Muhammed Ali Aydın Serdar Madendere Oktay Kaya Ebru Taştekin Tevfik Aktoz Pioglitazone Eases Testicular Torsion/Detorsion-Induced Ischemia- Reperfusion Injury in Rats Journal of Urological Surgery testicular torsion ischemia reperfusion |
| title | Pioglitazone Eases Testicular Torsion/Detorsion-Induced Ischemia- Reperfusion Injury in Rats |
| title_full | Pioglitazone Eases Testicular Torsion/Detorsion-Induced Ischemia- Reperfusion Injury in Rats |
| title_fullStr | Pioglitazone Eases Testicular Torsion/Detorsion-Induced Ischemia- Reperfusion Injury in Rats |
| title_full_unstemmed | Pioglitazone Eases Testicular Torsion/Detorsion-Induced Ischemia- Reperfusion Injury in Rats |
| title_short | Pioglitazone Eases Testicular Torsion/Detorsion-Induced Ischemia- Reperfusion Injury in Rats |
| title_sort | pioglitazone eases testicular torsion detorsion induced ischemia reperfusion injury in rats |
| topic | testicular torsion ischemia reperfusion |
| url |
http://jurolsurgery.org/archives/archive-detail/article-preview/pioglitazone-eases-testicular-torsion-detorsion-nd/60541
|
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