Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset

Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset

Abstract The regulation of autoimmunity against pancreatic islet β cells for type 1 diabetes (T1D) onset is still unclear. NOD/ShiLtJ (NOD) mice are prone to the onset of autoimmune diabetes, but its congenic strain, ALR/Lt (ALR), is not. Here we show that dendritic cells (DC) in ALR mice have impai...

Full description

Bibliographic Details
Main Authors: Jing Zhang, Yuan Zou, Longmin Chen, Fei Sun, Qianqian Xu, Qing Zhou, Yi Wang, Xi Luo, Na Wang, Yang Li, Shu Zhang, Fei Xiong, Ping Yang, Shiwei Liu, Tao Yang, Jianping Weng, Décio L. Eizirik, Jinhua Yan, Zhiguang Zhou, Cong-Yi Wang
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41534-w

Internet

https://doi.org/10.1038/s41467-023-41534-w

Similar Items