Interleukin 7-expressing fibroblasts promote breast cancer growth through sustenance of tumor cell stemness

Interleukin 7-expressing fibroblasts promote breast cancer growth through sustenance of tumor cell stemness

The tumor microenvironment harbors cancer-associated fibroblasts that function as major modulators of cancer progression. Here, we assessed to which extent distinct cancer-associated fibroblast subsets impact mammary carcinoma growth and cancer cell stemness in an orthotopic murine model. We found t...

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Bibliographic Details
Main Authors: Maximilian Boesch, Lucas Onder, Hung-Wei Cheng, Mario Novkovic, Urs Mörbe, Sieghart Sopper, Guenther Gastl, Wolfram Jochum, Thomas Ruhstaller, Michael Knauer, Burkhard Ludewig
Format: Article
Language:English
Published: Taylor & Francis Group 2018-04-01
Series:OncoImmunology
Subjects:
breast cancer
tumor microenvironment
interleukin 7
cancer-associated fibroblast
cancer stem cells
cxcl12
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1414129

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