Serum leptin levels in patients with chronic kidney disease and hypertensive heart disease: An observational cross‐sectional study
Abstract Background and Aim Adipocytes secrete a peptide hormone called leptin, which plays a crucial role in controlling appetite and energy expenditure. Alterations in leptin concentrations are associated with CKD‐related cardiovascular problems such as hypertensive heart disease (HHD). Despite th...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.1053 |
| _version_ | 1797737734306004992 |
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| author | Emmanuel K. Ofori Christian N. Adekena Vincent Boima Henry Asare‐Anane Ernest Yorke Eric N. Y. Nyarko Bismark N. Mohammed Emmanuel Quansah Sisitha U. Jayasinghe Seth D. Amanquah |
| author_facet | Emmanuel K. Ofori Christian N. Adekena Vincent Boima Henry Asare‐Anane Ernest Yorke Eric N. Y. Nyarko Bismark N. Mohammed Emmanuel Quansah Sisitha U. Jayasinghe Seth D. Amanquah |
| author_sort | Emmanuel K. Ofori |
| collection | DOAJ |
| description | Abstract Background and Aim Adipocytes secrete a peptide hormone called leptin, which plays a crucial role in controlling appetite and energy expenditure. Alterations in leptin concentrations are associated with CKD‐related cardiovascular problems such as hypertensive heart disease (HHD). Despite the link, data on the precise function of leptin in people with CKD and HHD is scant. Methods An observational cross‐sectional study involving a total of 108 participants (72 CKD patients with HHD and 36 healthy controls). Their demographic and anthropometric information was collected using a standardized questionnaire. Certain clinical measures such as blood pressure and body mass index (BMI) were assessed. Fasting blood samples were analyzed for levels of plasma glucose (FPG), lipids, creatinine, and leptin. Data were analyzed with SPSS v23. Results Leptin, FPG, creatinine and triglyceride levels were all significantly higher in CKD patients with HHD compared to controls (p < 0.01 for all). Furthermore, advanced CKD status (being in stage 5), having a 6‐year diagnosis of HHD, being female, having a higher BMI, and elevation in levels of HDL and FPG contributed significantly to the variance in serum leptin levels in the case group (β = 0.37, 0.22, 0.19, 0.18, 0.27, 0.28; p < 0.05 for all). In the control group, the female gender had the biggest unique effect on circulating leptin levels, followed by BMI and eGFR (β = 0.71, 0.34, −0.22; p < 0.01 for all). Conclusion Patients with CKD who also had HHD reported considerably higher circulating leptin levels. Significantly higher blood leptin levels were shown to be associated with CKD stage 5 in the case group. These results are consistent with the role of leptin in the metabolic complexity seen in CKD patients. There needs to be more research into treatments that aim to lower leptin levels in CKD patients with HHD. |
| first_indexed | 2024-03-12T13:33:41Z |
| format | Article |
| id | doaj.art-cc35f7e3bacd42e8b41cd48a51e89718 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-12T13:33:41Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-cc35f7e3bacd42e8b41cd48a51e897182023-08-24T06:32:46ZengWileyHealth Science Reports2398-88352023-01-0161n/an/a10.1002/hsr2.1053Serum leptin levels in patients with chronic kidney disease and hypertensive heart disease: An observational cross‐sectional studyEmmanuel K. Ofori0Christian N. Adekena1Vincent Boima2Henry Asare‐Anane3Ernest Yorke4Eric N. Y. Nyarko5Bismark N. Mohammed6Emmanuel Quansah7Sisitha U. Jayasinghe8Seth D. Amanquah9Department of Chemical Pathology University of Ghana Medical School Accra GhanaDepartment of Chemical Pathology University of Ghana Medical School Accra GhanaDepartment of Medicine and Therapeutics University of Ghana Medical School Accra GhanaDepartment of Chemical Pathology University of Ghana Medical School Accra GhanaDepartment of Medicine and Therapeutics University of Ghana Medical School Accra GhanaDepartment of Chemical Pathology University of Ghana Medical School Accra GhanaDepartment of Chemical Pathology University of Ghana Medical School Accra GhanaUniversity of Ghana Medical Center Accra GhanaSchool of Health Sciences University of Tasmania Hobart Tasmania AustraliaDepartment of Chemical Pathology University of Ghana Medical School Accra GhanaAbstract Background and Aim Adipocytes secrete a peptide hormone called leptin, which plays a crucial role in controlling appetite and energy expenditure. Alterations in leptin concentrations are associated with CKD‐related cardiovascular problems such as hypertensive heart disease (HHD). Despite the link, data on the precise function of leptin in people with CKD and HHD is scant. Methods An observational cross‐sectional study involving a total of 108 participants (72 CKD patients with HHD and 36 healthy controls). Their demographic and anthropometric information was collected using a standardized questionnaire. Certain clinical measures such as blood pressure and body mass index (BMI) were assessed. Fasting blood samples were analyzed for levels of plasma glucose (FPG), lipids, creatinine, and leptin. Data were analyzed with SPSS v23. Results Leptin, FPG, creatinine and triglyceride levels were all significantly higher in CKD patients with HHD compared to controls (p < 0.01 for all). Furthermore, advanced CKD status (being in stage 5), having a 6‐year diagnosis of HHD, being female, having a higher BMI, and elevation in levels of HDL and FPG contributed significantly to the variance in serum leptin levels in the case group (β = 0.37, 0.22, 0.19, 0.18, 0.27, 0.28; p < 0.05 for all). In the control group, the female gender had the biggest unique effect on circulating leptin levels, followed by BMI and eGFR (β = 0.71, 0.34, −0.22; p < 0.01 for all). Conclusion Patients with CKD who also had HHD reported considerably higher circulating leptin levels. Significantly higher blood leptin levels were shown to be associated with CKD stage 5 in the case group. These results are consistent with the role of leptin in the metabolic complexity seen in CKD patients. There needs to be more research into treatments that aim to lower leptin levels in CKD patients with HHD.https://doi.org/10.1002/hsr2.1053body mass indexchronic kidney diseaseglomerular filtration ratehypertensionleptin |
| spellingShingle | Emmanuel K. Ofori Christian N. Adekena Vincent Boima Henry Asare‐Anane Ernest Yorke Eric N. Y. Nyarko Bismark N. Mohammed Emmanuel Quansah Sisitha U. Jayasinghe Seth D. Amanquah Serum leptin levels in patients with chronic kidney disease and hypertensive heart disease: An observational cross‐sectional study Health Science Reports body mass index chronic kidney disease glomerular filtration rate hypertension leptin |
| title | Serum leptin levels in patients with chronic kidney disease and hypertensive heart disease: An observational cross‐sectional study |
| title_full | Serum leptin levels in patients with chronic kidney disease and hypertensive heart disease: An observational cross‐sectional study |
| title_fullStr | Serum leptin levels in patients with chronic kidney disease and hypertensive heart disease: An observational cross‐sectional study |
| title_full_unstemmed | Serum leptin levels in patients with chronic kidney disease and hypertensive heart disease: An observational cross‐sectional study |
| title_short | Serum leptin levels in patients with chronic kidney disease and hypertensive heart disease: An observational cross‐sectional study |
| title_sort | serum leptin levels in patients with chronic kidney disease and hypertensive heart disease an observational cross sectional study |
| topic | body mass index chronic kidney disease glomerular filtration rate hypertension leptin |
| url | https://doi.org/10.1002/hsr2.1053 |
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