Focal Scleral Nodule and Scleroderma: report of one case and an observational series
Objective: a) To report an original case of focal scleral nodule (FSN) in a patient affected by collagen’s systemic disease; b) to investigate the possible correlation between the two clinical entities by means of an observational case series. Case Presentation: A 74-year-old Caucasian woman was re...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Verduci Editore
2022-08-01
|
| Series: | Beyond Rheumatology |
| Subjects: | |
| Online Access: | https://www.beyond-rheumatology.org/wp-content/uploads/sites/10/2022/08/e394.pdf |
| _version_ | 1797831434460725248 |
|---|---|
| author | P. Mora A. Apollonio A. Ariani M. Longhena G. Calzetti S. Tedesco S. Gandolfi M. Angi |
| author_facet | P. Mora A. Apollonio A. Ariani M. Longhena G. Calzetti S. Tedesco S. Gandolfi M. Angi |
| author_sort | P. Mora |
| collection | DOAJ |
| description | Objective: a) To report an original case of focal scleral nodule (FSN) in a patient affected by collagen’s systemic disease; b) to investigate the possible correlation between the two clinical entities by means of an observational case series.
Case Presentation: A 74-year-old Caucasian woman was referred on the suspicion of choroidal tumor. She was affected by Systemic Sclerosis (SSc), with a history of an ancient ovarian tumor and a recent severe bacterial pneumonia. Ocular investigations, associated with total body oncological follow up and blood investigations for granulomatous diseases, supported the diagnosis of FSN. Mydriatic fundoscopy was then performed in cohort of 62 eyes of patients affected by confirmed SSc excluding other similar conditions.
Conclusions: The simultaneous presence of FSN and SSc has never been reported. The present series has excluded these concomitant findings in a cohort of confirmed SSc subjects. It is probable that SSc alone is not a sufficient condition to promote FSN formation. Further events (e.g., bacterial infections) may play a role in triggering a type 1 collagen over-deposition. |
| first_indexed | 2024-04-09T13:51:50Z |
| format | Article |
| id | doaj.art-cc364c3c6a8c4712812b6ed6e31111ea |
| institution | Directory Open Access Journal |
| issn | 2612-5110 |
| language | English |
| last_indexed | 2024-04-09T13:51:50Z |
| publishDate | 2022-08-01 |
| publisher | Verduci Editore |
| record_format | Article |
| series | Beyond Rheumatology |
| spelling | doaj.art-cc364c3c6a8c4712812b6ed6e31111ea2023-05-08T14:41:26ZengVerduci EditoreBeyond Rheumatology2612-51102022-08-01410.53238/br_20228_394394Focal Scleral Nodule and Scleroderma: report of one case and an observational seriesP. Mora0A. Apollonio1A. Ariani2M. Longhena3G. Calzetti4S. Tedesco5S. Gandolfi6M. Angi7Ophthalmology Unit, University Hospital of Parma, Parma, ItalyOphthalmology Unit, University Hospital of Parma, Parma, ItalyInternal Medicine and Rheumatology Unit, Azienda Ospedaliero-Universitaria di Parma, Parma, ItalyOphthalmology Unit, University Hospital of Parma, Parma, ItalyOphthalmology Unit, University Hospital of Parma, Parma, ItalyOphthalmology Unit, University Hospital of Parma, Parma, ItalyOphthalmology Unit, University Hospital of Parma, Parma, ItalyDepartment of Surgical Oncology, Ocular Oncology Service, Fondazione IRCCS Istituto Nazionale Tumori, Milan, ItalyObjective: a) To report an original case of focal scleral nodule (FSN) in a patient affected by collagen’s systemic disease; b) to investigate the possible correlation between the two clinical entities by means of an observational case series. Case Presentation: A 74-year-old Caucasian woman was referred on the suspicion of choroidal tumor. She was affected by Systemic Sclerosis (SSc), with a history of an ancient ovarian tumor and a recent severe bacterial pneumonia. Ocular investigations, associated with total body oncological follow up and blood investigations for granulomatous diseases, supported the diagnosis of FSN. Mydriatic fundoscopy was then performed in cohort of 62 eyes of patients affected by confirmed SSc excluding other similar conditions. Conclusions: The simultaneous presence of FSN and SSc has never been reported. The present series has excluded these concomitant findings in a cohort of confirmed SSc subjects. It is probable that SSc alone is not a sufficient condition to promote FSN formation. Further events (e.g., bacterial infections) may play a role in triggering a type 1 collagen over-deposition.https://www.beyond-rheumatology.org/wp-content/uploads/sites/10/2022/08/e394.pdffocal scleral nodulesystemic sclerodermapathogenesis |
| spellingShingle | P. Mora A. Apollonio A. Ariani M. Longhena G. Calzetti S. Tedesco S. Gandolfi M. Angi Focal Scleral Nodule and Scleroderma: report of one case and an observational series Beyond Rheumatology focal scleral nodule systemic scleroderma pathogenesis |
| title | Focal Scleral Nodule and Scleroderma: report of one case and an observational series |
| title_full | Focal Scleral Nodule and Scleroderma: report of one case and an observational series |
| title_fullStr | Focal Scleral Nodule and Scleroderma: report of one case and an observational series |
| title_full_unstemmed | Focal Scleral Nodule and Scleroderma: report of one case and an observational series |
| title_short | Focal Scleral Nodule and Scleroderma: report of one case and an observational series |
| title_sort | focal scleral nodule and scleroderma report of one case and an observational series |
| topic | focal scleral nodule systemic scleroderma pathogenesis |
| url | https://www.beyond-rheumatology.org/wp-content/uploads/sites/10/2022/08/e394.pdf |
| work_keys_str_mv | AT pmora focalscleralnoduleandsclerodermareportofonecaseandanobservationalseries AT aapollonio focalscleralnoduleandsclerodermareportofonecaseandanobservationalseries AT aariani focalscleralnoduleandsclerodermareportofonecaseandanobservationalseries AT mlonghena focalscleralnoduleandsclerodermareportofonecaseandanobservationalseries AT gcalzetti focalscleralnoduleandsclerodermareportofonecaseandanobservationalseries AT stedesco focalscleralnoduleandsclerodermareportofonecaseandanobservationalseries AT sgandolfi focalscleralnoduleandsclerodermareportofonecaseandanobservationalseries AT mangi focalscleralnoduleandsclerodermareportofonecaseandanobservationalseries |