A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performance

The design of feedback biomolecular controllers is essential to synthetically regulate biological processes in a robust and timely fashion. Here the authors introduce a wide array of biomolecular Proportional-Integral-Derivative (PID) controllers that are capable of enhancing stability and dynamic p...

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Main Authors: Maurice Filo, Sant Kumar, Mustafa Khammash
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29640-7
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author Maurice Filo
Sant Kumar
Mustafa Khammash
author_facet Maurice Filo
Sant Kumar
Mustafa Khammash
author_sort Maurice Filo
collection DOAJ
description The design of feedback biomolecular controllers is essential to synthetically regulate biological processes in a robust and timely fashion. Here the authors introduce a wide array of biomolecular Proportional-Integral-Derivative (PID) controllers that are capable of enhancing stability and dynamic performance, and also reducing stochastic noise.
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spelling doaj.art-cc37a5d5cf644f4e810ca1574748f3462022-12-22T00:08:05ZengNature PortfolioNature Communications2041-17232022-04-0113111910.1038/s41467-022-29640-7A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performanceMaurice Filo0Sant Kumar1Mustafa Khammash2Department of Biosystems Science and Engineering, ETH ZürichDepartment of Biosystems Science and Engineering, ETH ZürichDepartment of Biosystems Science and Engineering, ETH ZürichThe design of feedback biomolecular controllers is essential to synthetically regulate biological processes in a robust and timely fashion. Here the authors introduce a wide array of biomolecular Proportional-Integral-Derivative (PID) controllers that are capable of enhancing stability and dynamic performance, and also reducing stochastic noise.https://doi.org/10.1038/s41467-022-29640-7
spellingShingle Maurice Filo
Sant Kumar
Mustafa Khammash
A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performance
Nature Communications
title A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performance
title_full A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performance
title_fullStr A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performance
title_full_unstemmed A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performance
title_short A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performance
title_sort hierarchy of biomolecular proportional integral derivative feedback controllers for robust perfect adaptation and dynamic performance
url https://doi.org/10.1038/s41467-022-29640-7
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