Effect and mechanism of γ -ray irradiation on cyclic olefin copolymer in the sterilization dose range
BackgroundCyclic olefin copolymer (COC), synthesized by catalytic copolymerization of ethylene and norbornene, can be applied in medical devices and drug packaging, owing to its many outstanding properties such as good light transmittance, water vapor barrier and biocompatibility. When this type of...
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| Format: | Article |
| Language: | zho |
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Science Press
2022-03-01
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| Series: | He jishu |
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| Online Access: | http://www.hjs.sinap.ac.cn/thesisDetails#10.11889/j.0253-3219.2022.hjs.45.030302&lang=zh |
| _version_ | 1811169658068271104 |
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| author | ZHANG Fan JI Zhenyan SHEN Rongfang XING Zhe WU Guozhong |
| author_facet | ZHANG Fan JI Zhenyan SHEN Rongfang XING Zhe WU Guozhong |
| author_sort | ZHANG Fan |
| collection | DOAJ |
| description | BackgroundCyclic olefin copolymer (COC), synthesized by catalytic copolymerization of ethylene and norbornene, can be applied in medical devices and drug packaging, owing to its many outstanding properties such as good light transmittance, water vapor barrier and biocompatibility. When this type of medical devices or drug package is sterilized by high energy irradiation, COC will inevitably undergo changes such as radiation scission, oxidation, discoloration and so on. It is of great significance to explain the performance change of COC from the free radical reaction initiated by ionization radiation for the radiation sterilization application of COC medical supplies.PurposeThis study aims to investigate radiation effect of COC in the dose range of radiation sterilization.MethodsEffects of γ-rays on chemical structure, free radical, glass transition temperature, thermal stability, molecular weight distribution, surface properties and melt index of the irradiated COC with the sterilization dose were investigated by Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), ultraviolet-visible absorption spectroscopy (UV-vas), electron spin resonance spectroscopy (ESRS), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), gel permeation chromatography (GPC), water contact angle (WCA) and melt mass-flow rate measurement.ResultsThe concentration of free radicals produced by COC irradiation in air increases linearly with the increase of absorbed dose. With the increase of absorbed dose, radiation degradation is dominant, hence the average molecular weight of the radiation oxidation products include carbonyl and hydroxyl compounds decreases, and the surface hydrophilicity is enhanced whilst the melt index is increased.ConclusionsThe molecular chain breakage caused by radiation and the reaction between free radicals and oxygen are the main causes of COC degradation. |
| first_indexed | 2024-04-10T16:45:53Z |
| format | Article |
| id | doaj.art-cc3a0ab668e048999cf1a8166def6d02 |
| institution | Directory Open Access Journal |
| issn | 0253-3219 |
| language | zho |
| last_indexed | 2024-04-10T16:45:53Z |
| publishDate | 2022-03-01 |
| publisher | Science Press |
| record_format | Article |
| series | He jishu |
| spelling | doaj.art-cc3a0ab668e048999cf1a8166def6d022023-02-08T00:47:18ZzhoScience PressHe jishu0253-32192022-03-0145303030203030210.11889/j.0253-3219.2022.hjs.45.0303020253-3219（2022）03-0041-08Effect and mechanism of γ -ray irradiation on cyclic olefin copolymer in the sterilization dose rangeZHANG Fan0JI Zhenyan1SHEN Rongfang2XING Zhe3WU Guozhong4Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, ChinaShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, ChinaShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, ChinaShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, ChinaShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, ChinaBackgroundCyclic olefin copolymer (COC), synthesized by catalytic copolymerization of ethylene and norbornene, can be applied in medical devices and drug packaging, owing to its many outstanding properties such as good light transmittance, water vapor barrier and biocompatibility. When this type of medical devices or drug package is sterilized by high energy irradiation, COC will inevitably undergo changes such as radiation scission, oxidation, discoloration and so on. It is of great significance to explain the performance change of COC from the free radical reaction initiated by ionization radiation for the radiation sterilization application of COC medical supplies.PurposeThis study aims to investigate radiation effect of COC in the dose range of radiation sterilization.MethodsEffects of γ-rays on chemical structure, free radical, glass transition temperature, thermal stability, molecular weight distribution, surface properties and melt index of the irradiated COC with the sterilization dose were investigated by Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), ultraviolet-visible absorption spectroscopy (UV-vas), electron spin resonance spectroscopy (ESRS), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), gel permeation chromatography (GPC), water contact angle (WCA) and melt mass-flow rate measurement.ResultsThe concentration of free radicals produced by COC irradiation in air increases linearly with the increase of absorbed dose. With the increase of absorbed dose, radiation degradation is dominant, hence the average molecular weight of the radiation oxidation products include carbonyl and hydroxyl compounds decreases, and the surface hydrophilicity is enhanced whilst the melt index is increased.ConclusionsThe molecular chain breakage caused by radiation and the reaction between free radicals and oxygen are the main causes of COC degradation.http://www.hjs.sinap.ac.cn/thesisDetails#10.11889/j.0253-3219.2022.hjs.45.030302&lang=zhγ-ray irradiationcyclic olefin copolymersradiation degradation |
| spellingShingle | ZHANG Fan JI Zhenyan SHEN Rongfang XING Zhe WU Guozhong Effect and mechanism of γ -ray irradiation on cyclic olefin copolymer in the sterilization dose range He jishu γ-ray irradiation cyclic olefin copolymers radiation degradation |
| title | Effect and mechanism of γ -ray irradiation on cyclic olefin copolymer in the sterilization dose range |
| title_full | Effect and mechanism of γ -ray irradiation on cyclic olefin copolymer in the sterilization dose range |
| title_fullStr | Effect and mechanism of γ -ray irradiation on cyclic olefin copolymer in the sterilization dose range |
| title_full_unstemmed | Effect and mechanism of γ -ray irradiation on cyclic olefin copolymer in the sterilization dose range |
| title_short | Effect and mechanism of γ -ray irradiation on cyclic olefin copolymer in the sterilization dose range |
| title_sort | effect and mechanism of γ ray irradiation on cyclic olefin copolymer in the sterilization dose range |
| topic | γ-ray irradiation cyclic olefin copolymers radiation degradation |
| url | http://www.hjs.sinap.ac.cn/thesisDetails#10.11889/j.0253-3219.2022.hjs.45.030302&lang=zh |
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