Genomic ancestry and education level independently influence abdominal fat distributions in a Brazilian admixed population.
We aimed to identify the independent associations of genomic ancestry and education level with abdominal fat distributions in the 1982 Pelotas birth cohort study, Brazil. In 2,890 participants (1,409 men and 1,481 women), genomic ancestry was assessed using genotype data on 370,539 genome-wide varia...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5459508?pdf=render |
| _version_ | 1819078489034194944 |
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| author | Giovanny Vinícius Araújo de França Emanuella De Lucia Rolfe Bernardo Lessa Horta Denise Petrucci Gigante John S Yudkin Ken K Ong Cesar Gomes Victora |
| author_facet | Giovanny Vinícius Araújo de França Emanuella De Lucia Rolfe Bernardo Lessa Horta Denise Petrucci Gigante John S Yudkin Ken K Ong Cesar Gomes Victora |
| author_sort | Giovanny Vinícius Araújo de França |
| collection | DOAJ |
| description | We aimed to identify the independent associations of genomic ancestry and education level with abdominal fat distributions in the 1982 Pelotas birth cohort study, Brazil. In 2,890 participants (1,409 men and 1,481 women), genomic ancestry was assessed using genotype data on 370,539 genome-wide variants to quantify ancestral proportions in each individual. Years of completed education was used to indicate socio-economic position. Visceral fat depth and subcutaneous abdominal fat thickness were measured by ultrasound at age 29-31y; these measures were adjusted for BMI to indicate abdominal fat distributions. Linear regression models were performed, separately by sex. Admixture was observed between European (median proportion 85.3), African (6.6), and Native American (6.3) ancestries, with a strong inverse correlation between the African and European ancestry scores (ρ = -0.93; p<0.001). Independent of education level, African ancestry was inversely associated with both visceral and subcutaneous abdominal fat distributions in men (both P = 0.001), and inversely associated with subcutaneous abdominal fat distribution in women (p = 0.009). Independent of genomic ancestry, higher education level was associated with lower visceral fat, but higher subcutaneous fat, in both men and women (all p<0.001). Our findings, from an admixed population, indicate that both genomic ancestry and education level were independently associated with abdominal fat distribution in adults. African ancestry appeared to lower abdominal fat distributions, particularly in men. |
| first_indexed | 2024-12-21T19:13:54Z |
| format | Article |
| id | doaj.art-cc3a66db220e4f2aac5717a22eccaa4d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T19:13:54Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-cc3a66db220e4f2aac5717a22eccaa4d2022-12-21T18:53:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01126e017908510.1371/journal.pone.0179085Genomic ancestry and education level independently influence abdominal fat distributions in a Brazilian admixed population.Giovanny Vinícius Araújo de FrançaEmanuella De Lucia RolfeBernardo Lessa HortaDenise Petrucci GiganteJohn S YudkinKen K OngCesar Gomes VictoraWe aimed to identify the independent associations of genomic ancestry and education level with abdominal fat distributions in the 1982 Pelotas birth cohort study, Brazil. In 2,890 participants (1,409 men and 1,481 women), genomic ancestry was assessed using genotype data on 370,539 genome-wide variants to quantify ancestral proportions in each individual. Years of completed education was used to indicate socio-economic position. Visceral fat depth and subcutaneous abdominal fat thickness were measured by ultrasound at age 29-31y; these measures were adjusted for BMI to indicate abdominal fat distributions. Linear regression models were performed, separately by sex. Admixture was observed between European (median proportion 85.3), African (6.6), and Native American (6.3) ancestries, with a strong inverse correlation between the African and European ancestry scores (ρ = -0.93; p<0.001). Independent of education level, African ancestry was inversely associated with both visceral and subcutaneous abdominal fat distributions in men (both P = 0.001), and inversely associated with subcutaneous abdominal fat distribution in women (p = 0.009). Independent of genomic ancestry, higher education level was associated with lower visceral fat, but higher subcutaneous fat, in both men and women (all p<0.001). Our findings, from an admixed population, indicate that both genomic ancestry and education level were independently associated with abdominal fat distribution in adults. African ancestry appeared to lower abdominal fat distributions, particularly in men.http://europepmc.org/articles/PMC5459508?pdf=render |
| spellingShingle | Giovanny Vinícius Araújo de França Emanuella De Lucia Rolfe Bernardo Lessa Horta Denise Petrucci Gigante John S Yudkin Ken K Ong Cesar Gomes Victora Genomic ancestry and education level independently influence abdominal fat distributions in a Brazilian admixed population. PLoS ONE |
| title | Genomic ancestry and education level independently influence abdominal fat distributions in a Brazilian admixed population. |
| title_full | Genomic ancestry and education level independently influence abdominal fat distributions in a Brazilian admixed population. |
| title_fullStr | Genomic ancestry and education level independently influence abdominal fat distributions in a Brazilian admixed population. |
| title_full_unstemmed | Genomic ancestry and education level independently influence abdominal fat distributions in a Brazilian admixed population. |
| title_short | Genomic ancestry and education level independently influence abdominal fat distributions in a Brazilian admixed population. |
| title_sort | genomic ancestry and education level independently influence abdominal fat distributions in a brazilian admixed population |
| url | http://europepmc.org/articles/PMC5459508?pdf=render |
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