Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease
Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 wit...
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MDPI AG
2021-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/18/4052 |
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| author | Maria-Del-Carmen Moleon Estrella Martinez-Gomez Marisa Flook Andreina Peralta-Leal Juan Antonio Gallego Hortensia Sanchez-Gomez Maria Alharilla Montilla-Ibañez Emilio Dominguez-Durán Andres Soto-Varela Ismael Aran Lidia Frejo Jose A. Lopez-Escamez |
| author_facet | Maria-Del-Carmen Moleon Estrella Martinez-Gomez Marisa Flook Andreina Peralta-Leal Juan Antonio Gallego Hortensia Sanchez-Gomez Maria Alharilla Montilla-Ibañez Emilio Dominguez-Durán Andres Soto-Varela Ismael Aran Lidia Frejo Jose A. Lopez-Escamez |
| author_sort | Maria-Del-Carmen Moleon |
| collection | DOAJ |
| description | Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD, >50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL,1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (<i>p</i> = 0.004) and a higher prevalence of migraine than LOMD (<i>p</i> = 0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3, and CXCL4 were different between patients with MD or migraine and controls. |
| first_indexed | 2024-03-10T07:34:14Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T07:34:14Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-cc3b7fd9d84b4eda9cd14dc1555159e22023-11-22T13:38:44ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-011018405210.3390/jcm10184052Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere DiseaseMaria-Del-Carmen Moleon0Estrella Martinez-Gomez1Marisa Flook2Andreina Peralta-Leal3Juan Antonio Gallego4Hortensia Sanchez-Gomez5Maria Alharilla Montilla-Ibañez6Emilio Dominguez-Durán7Andres Soto-Varela8Ismael Aran9Lidia Frejo10Jose A. Lopez-Escamez11Otology and Neurotology Group CTS495, Department of Genomic Medicine, GENYO—Centre for Genomics and Oncological Research—Pfizer/University of Granada/Junta de Andalucía, PTS, 18016 Granada, SpainOtology and Neurotology Group CTS495, Department of Genomic Medicine, GENYO—Centre for Genomics and Oncological Research—Pfizer/University of Granada/Junta de Andalucía, PTS, 18016 Granada, SpainOtology and Neurotology Group CTS495, Department of Genomic Medicine, GENYO—Centre for Genomics and Oncological Research—Pfizer/University of Granada/Junta de Andalucía, PTS, 18016 Granada, SpainOtology and Neurotology Group CTS495, Department of Genomic Medicine, GENYO—Centre for Genomics and Oncological Research—Pfizer/University of Granada/Junta de Andalucía, PTS, 18016 Granada, SpainDepartment of Neurology, Hospital Universitario Virgen de las Nieves, Universidad de Granada, 18014 Granada, SpainOtoneurology Unit, Department of Otorhinolaryngology, University Hospital of Salamanca, IBSAL, 37007 Salamanca, SpainDepartment of Otorhinolaryngology, Complejo Hospitalario de Jaén, 23007 Jaen, SpainDepartment of Otolaryngology, Hospital Virgen Macarena, 41009 Sevilla, SpainDivision of Neurotology, Department of Otorhinolaryngology, Complexo Hospitalario Universitario, 15706 Santiago de Compostela, SpainDepartment of Otolaryngology, Complexo Hospitalario de Pontevedra, 36071 Pontevedra, SpainOtology and Neurotology Group CTS495, Department of Genomic Medicine, GENYO—Centre for Genomics and Oncological Research—Pfizer/University of Granada/Junta de Andalucía, PTS, 18016 Granada, SpainOtology and Neurotology Group CTS495, Department of Genomic Medicine, GENYO—Centre for Genomics and Oncological Research—Pfizer/University of Granada/Junta de Andalucía, PTS, 18016 Granada, SpainBackground: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD, >50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL,1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (<i>p</i> = 0.004) and a higher prevalence of migraine than LOMD (<i>p</i> = 0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3, and CXCL4 were different between patients with MD or migraine and controls.https://www.mdpi.com/2077-0383/10/18/4052hearing lossvertigomigrainecytokinesinflammationvestibular disorders |
| spellingShingle | Maria-Del-Carmen Moleon Estrella Martinez-Gomez Marisa Flook Andreina Peralta-Leal Juan Antonio Gallego Hortensia Sanchez-Gomez Maria Alharilla Montilla-Ibañez Emilio Dominguez-Durán Andres Soto-Varela Ismael Aran Lidia Frejo Jose A. Lopez-Escamez Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease Journal of Clinical Medicine hearing loss vertigo migraine cytokines inflammation vestibular disorders |
| title | Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease |
| title_full | Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease |
| title_fullStr | Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease |
| title_full_unstemmed | Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease |
| title_short | Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease |
| title_sort | clinical and cytokine profile in patients with early and late onset meniere disease |
| topic | hearing loss vertigo migraine cytokines inflammation vestibular disorders |
| url | https://www.mdpi.com/2077-0383/10/18/4052 |
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