Aggravation of ischemic brain injury by prion protein deficiency: Role of ERK-1/-2 and STAT-1

Aggravation of ischemic brain injury by prion protein deficiency: Role of ERK-1/-2 and STAT-1

The cellular isoform of prion protein, PrPc, may confer neuroprotection in the brain, according to recent studies. To elucidate the role of PrPc in stroke pathology, we subjected PrPc-knockout (Prnp0/0), wild-type and PrPc-transgenic (tga20) mice to 30 min of intraluminal middle cerebral artery occl...

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Bibliographic Details
Main Authors: Annett Spudich, Rico Frigg, Ertugrul Kilic, Ülkan Kilic, Bruno Oesch, Alex Raeber, Claudio L. Bassetti, Dirk M. Hermann
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Neurobiology of Disease
Subjects:
Middle cerebral artery occlusion
Neuroprotection
ERK-1/-2
STAT-1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105001130

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