Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants

Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants

Adjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-α and IL-6. Here we present sma...

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Bibliographic Details
Main Authors: Brittany A. Moser, Yoseline Escalante-Buendia, Rachel C. Steinhardt, Matthew G. Rosenberger, Britteny J. Cassaidy, Nihesh Naorem, Alfred C. Chon, Minh H. Nguyen, Ngoctran T. Tran, Aaron P. Esser-Kahn
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
adjuvants
vaccines
NF-κB
honokiol
capsaicin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.511513/full
Description
Summary:Adjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-α and IL-6. Here we present small molecule NF-κB inhibitors that can be used in combination with an immune adjuvant to both decrease markers associated with poor tolerability and improve the protective response of vaccination. Additionally, we synthesize a library of honokiol derivatives identifying several promising candidates for use in vaccine formulations.
ISSN:1664-3224

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