Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants
Adjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-α and IL-6. Here we present sma...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.511513/full |
| _version_ | 1818198922921771008 |
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| author | Brittany A. Moser Yoseline Escalante-Buendia Rachel C. Steinhardt Matthew G. Rosenberger Britteny J. Cassaidy Nihesh Naorem Alfred C. Chon Minh H. Nguyen Ngoctran T. Tran Aaron P. Esser-Kahn |
| author_facet | Brittany A. Moser Yoseline Escalante-Buendia Rachel C. Steinhardt Matthew G. Rosenberger Britteny J. Cassaidy Nihesh Naorem Alfred C. Chon Minh H. Nguyen Ngoctran T. Tran Aaron P. Esser-Kahn |
| author_sort | Brittany A. Moser |
| collection | DOAJ |
| description | Adjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-α and IL-6. Here we present small molecule NF-κB inhibitors that can be used in combination with an immune adjuvant to both decrease markers associated with poor tolerability and improve the protective response of vaccination. Additionally, we synthesize a library of honokiol derivatives identifying several promising candidates for use in vaccine formulations. |
| first_indexed | 2024-12-12T02:13:34Z |
| format | Article |
| id | doaj.art-cc3d65d6e09243538ec17878894fcfd3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T02:13:34Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-cc3d65d6e09243538ec17878894fcfd32022-12-22T00:41:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-09-011110.3389/fimmu.2020.511513511513Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine AdjuvantsBrittany A. Moser0Yoseline Escalante-Buendia1Rachel C. Steinhardt2Matthew G. Rosenberger3Britteny J. Cassaidy4Nihesh Naorem5Alfred C. Chon6Minh H. Nguyen7Ngoctran T. Tran8Aaron P. Esser-Kahn9Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, United StatesPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, United StatesPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, United StatesPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, United StatesPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, United StatesPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, United StatesPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, United StatesDepartment of Chemistry, Chemical Engineering and Materials Science, Biomedical Engineering, University of California, Irvine, Irvine, CA, United StatesDepartment of Chemistry, Chemical Engineering and Materials Science, Biomedical Engineering, University of California, Irvine, Irvine, CA, United StatesPritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, United StatesAdjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-α and IL-6. Here we present small molecule NF-κB inhibitors that can be used in combination with an immune adjuvant to both decrease markers associated with poor tolerability and improve the protective response of vaccination. Additionally, we synthesize a library of honokiol derivatives identifying several promising candidates for use in vaccine formulations.https://www.frontiersin.org/article/10.3389/fimmu.2020.511513/fulladjuvantsvaccinesNF-κBhonokiolcapsaicin |
| spellingShingle | Brittany A. Moser Yoseline Escalante-Buendia Rachel C. Steinhardt Matthew G. Rosenberger Britteny J. Cassaidy Nihesh Naorem Alfred C. Chon Minh H. Nguyen Ngoctran T. Tran Aaron P. Esser-Kahn Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants Frontiers in Immunology adjuvants vaccines NF-κB honokiol capsaicin |
| title | Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants |
| title_full | Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants |
| title_fullStr | Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants |
| title_full_unstemmed | Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants |
| title_short | Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants |
| title_sort | small molecule nf κb inhibitors as immune potentiators for enhancement of vaccine adjuvants |
| topic | adjuvants vaccines NF-κB honokiol capsaicin |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.511513/full |
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