Experience-driven rate modulation is reinstated during hippocampal replay
Replay, the sequential reactivation within a neuronal ensemble, is a central hippocampal mechanism postulated to drive memory processing. While both rate and place representations are used by hippocampal place cells to encode behavioral episodes, replay has been largely defined by only the latter –...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2022-08-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/79031 |
| _version_ | 1811320472716967936 |
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| author | Margot Tirole Marta Huelin Gorriz Masahiro Takigawa Lilia Kukovska Daniel Bendor |
| author_facet | Margot Tirole Marta Huelin Gorriz Masahiro Takigawa Lilia Kukovska Daniel Bendor |
| author_sort | Margot Tirole |
| collection | DOAJ |
| description | Replay, the sequential reactivation within a neuronal ensemble, is a central hippocampal mechanism postulated to drive memory processing. While both rate and place representations are used by hippocampal place cells to encode behavioral episodes, replay has been largely defined by only the latter – based on the fidelity of sequential activity across neighboring place fields. Here, we show that dorsal CA1 place cells in rats can modulate their firing rate between replay events of two different contexts. This experience-dependent phenomenon mirrors the same pattern of rate modulation observed during behavior and can be used independently from place information within replay sequences to discriminate between contexts. Our results reveal the existence of two complementary neural representations available for memory processes. |
| first_indexed | 2024-04-13T12:59:57Z |
| format | Article |
| id | doaj.art-cc403eda7f3f4d78a98f16adefc27373 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-13T12:59:57Z |
| publishDate | 2022-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-cc403eda7f3f4d78a98f16adefc273732022-12-22T02:45:57ZengeLife Sciences Publications LtdeLife2050-084X2022-08-011110.7554/eLife.79031Experience-driven rate modulation is reinstated during hippocampal replayMargot Tirole0https://orcid.org/0000-0003-0674-6690Marta Huelin Gorriz1https://orcid.org/0000-0002-0281-0627Masahiro Takigawa2https://orcid.org/0000-0002-0162-9017Lilia Kukovska3Daniel Bendor4https://orcid.org/0000-0001-6621-793XInstitute of Behavioural Neuroscience, University College London, London, United KingdomInstitute of Behavioural Neuroscience, University College London, London, United KingdomInstitute of Behavioural Neuroscience, University College London, London, United KingdomInstitute of Behavioural Neuroscience, University College London, London, United KingdomInstitute of Behavioural Neuroscience, University College London, London, United KingdomReplay, the sequential reactivation within a neuronal ensemble, is a central hippocampal mechanism postulated to drive memory processing. While both rate and place representations are used by hippocampal place cells to encode behavioral episodes, replay has been largely defined by only the latter – based on the fidelity of sequential activity across neighboring place fields. Here, we show that dorsal CA1 place cells in rats can modulate their firing rate between replay events of two different contexts. This experience-dependent phenomenon mirrors the same pattern of rate modulation observed during behavior and can be used independently from place information within replay sequences to discriminate between contexts. Our results reveal the existence of two complementary neural representations available for memory processes.https://elifesciences.org/articles/79031replayhippocampussleepmemory consolidationneural codingplace cell |
| spellingShingle | Margot Tirole Marta Huelin Gorriz Masahiro Takigawa Lilia Kukovska Daniel Bendor Experience-driven rate modulation is reinstated during hippocampal replay eLife replay hippocampus sleep memory consolidation neural coding place cell |
| title | Experience-driven rate modulation is reinstated during hippocampal replay |
| title_full | Experience-driven rate modulation is reinstated during hippocampal replay |
| title_fullStr | Experience-driven rate modulation is reinstated during hippocampal replay |
| title_full_unstemmed | Experience-driven rate modulation is reinstated during hippocampal replay |
| title_short | Experience-driven rate modulation is reinstated during hippocampal replay |
| title_sort | experience driven rate modulation is reinstated during hippocampal replay |
| topic | replay hippocampus sleep memory consolidation neural coding place cell |
| url | https://elifesciences.org/articles/79031 |
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