A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island
Background: This study aimed to evaluate the prognosis of COVID-19 patients in Reunion Island, with a particular focus on the management of patients with hypoxemic pneumonia. Methods: This retrospective observational study was conducted from 11 March to 17 April 2020 at the only hospital authorized...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-12-01
|
| Series: | Journal of Global Antimicrobial Resistance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221371652030206X |
| _version_ | 1829483473591599104 |
|---|---|
| author | Arthur Dubernet Kevin Larsen Laurie Masse Jérôme Allyn Emilie Foch Lea Bruneau Adrien Maillot Marie Lagrange-Xelot Vincent Thomas Marie-Christine Jaffar-Bandjee Loraine Gauzere Loic Raffray Karine Borsu Servane Dibernardo Stéphane Renaud Michel André Diane Moreau Julien Jabot Nathalie Coolen-Allou Nicolas Allou |
| author_facet | Arthur Dubernet Kevin Larsen Laurie Masse Jérôme Allyn Emilie Foch Lea Bruneau Adrien Maillot Marie Lagrange-Xelot Vincent Thomas Marie-Christine Jaffar-Bandjee Loraine Gauzere Loic Raffray Karine Borsu Servane Dibernardo Stéphane Renaud Michel André Diane Moreau Julien Jabot Nathalie Coolen-Allou Nicolas Allou |
| author_sort | Arthur Dubernet |
| collection | DOAJ |
| description | Background: This study aimed to evaluate the prognosis of COVID-19 patients in Reunion Island, with a particular focus on the management of patients with hypoxemic pneumonia. Methods: This retrospective observational study was conducted from 11 March to 17 April 2020 at the only hospital authorized to manage patients with COVID-19 in Reunion Island. Results: Over the study period, 164 out of 398 patients (41.2%) infected with COVID-19 were admitted to Félix Guyon University Hospital. Of these, 36 (22%) developed hypoxemic pneumonia. Patients with hypoxemic pneumonia were aged 66 [56–77] years, 69% were male and 33% had hypertension. Ten patients (27.8%) were hospitalized in intensive care unit (ICU). Hydroxychloroquine/azithromycin treatment was associated with a lower ICU admission rate (P = 0.008). None of the 6 patients treated with corticosteroids were hospitalized in ICU (P = 0.16). There were no deaths at follow up (minimum 80 days). Conclusions: Despite the risk profile of COVID-19 patients with severe hypoxemic pneumonia, the mortality rate of the disease in Reunion Island was 0%. This may be due to the care bundle used in our hospital (early hospitalisation, treatment with hydroxychloroquine/azithromycin and/or corticosteroids, non-invasive respiratory support, etc). |
| first_indexed | 2024-12-14T22:08:14Z |
| format | Article |
| id | doaj.art-cc40a636f5564a179b2f3b10be97e1bf |
| institution | Directory Open Access Journal |
| issn | 2213-7165 |
| language | English |
| last_indexed | 2024-12-14T22:08:14Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj.art-cc40a636f5564a179b2f3b10be97e1bf2022-12-21T22:45:49ZengElsevierJournal of Global Antimicrobial Resistance2213-71652020-12-012313A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion IslandArthur Dubernet0Kevin Larsen1Laurie Masse2Jérôme Allyn3Emilie Foch4Lea Bruneau5Adrien Maillot6Marie Lagrange-Xelot7Vincent Thomas8Marie-Christine Jaffar-Bandjee9Loraine Gauzere10Loic Raffray11Karine Borsu12Servane Dibernardo13Stéphane Renaud14Michel André15Diane Moreau16Julien Jabot17Nathalie Coolen-Allou18Nicolas Allou19Pneumologie, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FrancePneumologie, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FrancePneumologie, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FranceRéanimation polyvalente, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France; Département d’Informatique Clinique, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FrancePneumologie, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FranceINSERM CIC 1410 Clinical and Epidemiology, University Hospital, Saint Pierre, Réunion Island, France; Department of Public Health and Research Support, Methodological Support and Biostatistics Unit, University Hospital, Saint Denis, Réunion Island, FranceDepartment of Public Health and Research Support, Methodological Support and Biostatistics Unit, University Hospital, Saint Denis, Réunion Island, FranceService des Maladies Infectieuses, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FranceMicrobiologie, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FranceMicrobiologie, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FranceMédecine Interne, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FranceMédecine Interne, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FranceMédecine Polyvalente, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FranceMédecine Polyvalente, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FranceGériatrie, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FrancePneumologie, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FrancePneumologie, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FranceRéanimation polyvalente, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FrancePneumologie, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, FranceRéanimation polyvalente, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France; Département d’Informatique Clinique, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France; Corresponding author at: Réanimation polyvalente, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France.Background: This study aimed to evaluate the prognosis of COVID-19 patients in Reunion Island, with a particular focus on the management of patients with hypoxemic pneumonia. Methods: This retrospective observational study was conducted from 11 March to 17 April 2020 at the only hospital authorized to manage patients with COVID-19 in Reunion Island. Results: Over the study period, 164 out of 398 patients (41.2%) infected with COVID-19 were admitted to Félix Guyon University Hospital. Of these, 36 (22%) developed hypoxemic pneumonia. Patients with hypoxemic pneumonia were aged 66 [56–77] years, 69% were male and 33% had hypertension. Ten patients (27.8%) were hospitalized in intensive care unit (ICU). Hydroxychloroquine/azithromycin treatment was associated with a lower ICU admission rate (P = 0.008). None of the 6 patients treated with corticosteroids were hospitalized in ICU (P = 0.16). There were no deaths at follow up (minimum 80 days). Conclusions: Despite the risk profile of COVID-19 patients with severe hypoxemic pneumonia, the mortality rate of the disease in Reunion Island was 0%. This may be due to the care bundle used in our hospital (early hospitalisation, treatment with hydroxychloroquine/azithromycin and/or corticosteroids, non-invasive respiratory support, etc).http://www.sciencedirect.com/science/article/pii/S221371652030206XCOVID-19SARS-CoV-2HydroxychloroquineAzithromycinCorticosteroids |
| spellingShingle | Arthur Dubernet Kevin Larsen Laurie Masse Jérôme Allyn Emilie Foch Lea Bruneau Adrien Maillot Marie Lagrange-Xelot Vincent Thomas Marie-Christine Jaffar-Bandjee Loraine Gauzere Loic Raffray Karine Borsu Servane Dibernardo Stéphane Renaud Michel André Diane Moreau Julien Jabot Nathalie Coolen-Allou Nicolas Allou A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island Journal of Global Antimicrobial Resistance COVID-19 SARS-CoV-2 Hydroxychloroquine Azithromycin Corticosteroids |
| title | A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island |
| title_full | A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island |
| title_fullStr | A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island |
| title_full_unstemmed | A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island |
| title_short | A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island |
| title_sort | comprehensive strategy for the early treatment of covid 19 with azithromycin hydroxychloroquine and or corticosteroids results of a retrospective observational study in the french overseas department of reunion island |
| topic | COVID-19 SARS-CoV-2 Hydroxychloroquine Azithromycin Corticosteroids |
| url | http://www.sciencedirect.com/science/article/pii/S221371652030206X |
| work_keys_str_mv | AT arthurdubernet acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT kevinlarsen acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT lauriemasse acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT jeromeallyn acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT emiliefoch acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT leabruneau acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT adrienmaillot acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT marielagrangexelot acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT vincentthomas acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT mariechristinejaffarbandjee acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT lorainegauzere acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT loicraffray acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT karineborsu acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT servanedibernardo acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT stephanerenaud acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT michelandre acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT dianemoreau acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT julienjabot acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT nathaliecoolenallou acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT nicolasallou acomprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT arthurdubernet comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT kevinlarsen comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT lauriemasse comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT jeromeallyn comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT emiliefoch comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT leabruneau comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT adrienmaillot comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT marielagrangexelot comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT vincentthomas comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT mariechristinejaffarbandjee comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT lorainegauzere comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT loicraffray comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT karineborsu comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT servanedibernardo comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT stephanerenaud comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT michelandre comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT dianemoreau comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT julienjabot comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT nathaliecoolenallou comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland AT nicolasallou comprehensivestrategyfortheearlytreatmentofcovid19withazithromycinhydroxychloroquineandorcorticosteroidsresultsofaretrospectiveobservationalstudyinthefrenchoverseasdepartmentofreunionisland |