Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in Rats
BackgroundDiabetic cardiomyopathy is an important causal factor in morbidity and mortality among diabetic patients, and currently, no effective means are available to reverse its pathological progress. The purpose of the present study was to investigate the effect of ginger extract on apolipoprotein...
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Korean Diabetes Association
2016-02-01
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| Series: | Diabetes & Metabolism Journal |
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| Online Access: | https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-40-46.pdf |
| _version_ | 1818323764756086784 |
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| author | Behrouz Ilkhanizadeh Alireza Shirpoor Mohamad hasan Khadem Ansari Samira Nemati Yusef Rasmi |
| author_facet | Behrouz Ilkhanizadeh Alireza Shirpoor Mohamad hasan Khadem Ansari Samira Nemati Yusef Rasmi |
| author_sort | Behrouz Ilkhanizadeh |
| collection | DOAJ |
| description | BackgroundDiabetic cardiomyopathy is an important causal factor in morbidity and mortality among diabetic patients, and currently, no effective means are available to reverse its pathological progress. The purpose of the present study was to investigate the effect of ginger extract on apolipoproteins (apo) A and B, hyperhomocysteinemia, cathepsin G and leptin changes, as well as cardiac fibrosis and heart muscle cell proliferation under hyperglycemic conditions in vivo.MethodsTwenty-four male Wistar rats were divided into three groups, namely: control, non-treated diabetic, and ginger extract-treated diabetic groups. The ginger extract-treated diabetic group received a 50 mg daily dose of ginger extract intragastrically for 6 weeks.ResultsThe results revealed concurrent significant increases in plasma C-reactive protein (CRP), homocysteine (Hcy), cathepsin G and apoB levels and decreases in apoA and leptin levels in the non-treated diabetic group compared to the control group. Moreover, heart structural changes, including fibrosis and heart muscle cell proliferation, were observed in non-treated diabetic rats compared to the control rats. Significant amelioration of changes in the heart structure together with restoration of the elevated levels of Hcy and CRP, leptin, cathepsin G, and apoA and B were found in the ginger extract-treated diabetic group compared to the non-treated diabetic group.ConclusionThe findings indicated that ginger extract significantly reduces heart structural abnormalities in diabetic rats and that these effects might be associated with improvements in serum apo, leptin, cathepsin G, and Hcy levels and with the antioxidant properties of ginger extract. |
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| format | Article |
| id | doaj.art-cc413805398b4bbea8c22f24f2c27010 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-13T11:17:53Z |
| publishDate | 2016-02-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-cc413805398b4bbea8c22f24f2c270102022-12-21T23:48:34ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872016-02-01401465310.4093/dmj.2016.40.1.4614745Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in RatsBehrouz Ilkhanizadeh0Alireza Shirpoor1Mohamad hasan Khadem Ansari2Samira Nemati3Yusef Rasmi4Department of Pathology, Urmia University of Medical Sciences Faculty of Medicine, Urmia, Iran.Department of Physiology, Urmia University of Medical Sciences Faculty of Medicine, Urmia, Iran.Department of Biochemistry, Urmia University of Medical Sciences Faculty of Medicine, Urmia, Iran.Department of Physiology, Urmia University of Medical Sciences Faculty of Medicine, Urmia, Iran.Department of Biochemistry, Urmia University of Medical Sciences Faculty of Medicine, Urmia, Iran.BackgroundDiabetic cardiomyopathy is an important causal factor in morbidity and mortality among diabetic patients, and currently, no effective means are available to reverse its pathological progress. The purpose of the present study was to investigate the effect of ginger extract on apolipoproteins (apo) A and B, hyperhomocysteinemia, cathepsin G and leptin changes, as well as cardiac fibrosis and heart muscle cell proliferation under hyperglycemic conditions in vivo.MethodsTwenty-four male Wistar rats were divided into three groups, namely: control, non-treated diabetic, and ginger extract-treated diabetic groups. The ginger extract-treated diabetic group received a 50 mg daily dose of ginger extract intragastrically for 6 weeks.ResultsThe results revealed concurrent significant increases in plasma C-reactive protein (CRP), homocysteine (Hcy), cathepsin G and apoB levels and decreases in apoA and leptin levels in the non-treated diabetic group compared to the control group. Moreover, heart structural changes, including fibrosis and heart muscle cell proliferation, were observed in non-treated diabetic rats compared to the control rats. Significant amelioration of changes in the heart structure together with restoration of the elevated levels of Hcy and CRP, leptin, cathepsin G, and apoA and B were found in the ginger extract-treated diabetic group compared to the non-treated diabetic group.ConclusionThe findings indicated that ginger extract significantly reduces heart structural abnormalities in diabetic rats and that these effects might be associated with improvements in serum apo, leptin, cathepsin G, and Hcy levels and with the antioxidant properties of ginger extract.https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-40-46.pdfDiabetesGingerHeartLeptinRats |
| spellingShingle | Behrouz Ilkhanizadeh Alireza Shirpoor Mohamad hasan Khadem Ansari Samira Nemati Yusef Rasmi Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in Rats Diabetes & Metabolism Journal Diabetes Ginger Heart Leptin Rats |
| title | Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in Rats |
| title_full | Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in Rats |
| title_fullStr | Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in Rats |
| title_full_unstemmed | Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in Rats |
| title_short | Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in Rats |
| title_sort | protective effects of ginger zingiber officinale extract against diabetes induced heart abnormality in rats |
| topic | Diabetes Ginger Heart Leptin Rats |
| url | https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-40-46.pdf |
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