Nicotinic Acid Improves Endurance Performance of Mice Subjected to Treadmill Exercise
Recently, administration of nicotinic acid (NA) at a pharmacological dose was found to induce a similar change in the muscle´s contractile and metabolic phenotype as observed in response to endurance exercise. Thus, the hypothesis was tested that combined NA administration and endurance exercise pro...
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MDPI AG
2020-04-01
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| Online Access: | https://www.mdpi.com/2218-1989/10/4/138 |
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| author | Robert Ringseis Denise K. Gessner Anna M. Beer Yvonne Albrecht Gaiping Wen Erika Most Karsten Krüger Klaus Eder |
| author_facet | Robert Ringseis Denise K. Gessner Anna M. Beer Yvonne Albrecht Gaiping Wen Erika Most Karsten Krüger Klaus Eder |
| author_sort | Robert Ringseis |
| collection | DOAJ |
| description | Recently, administration of nicotinic acid (NA) at a pharmacological dose was found to induce a similar change in the muscle´s contractile and metabolic phenotype as observed in response to endurance exercise. Thus, the hypothesis was tested that combined NA administration and endurance exercise promotes the adaptation of muscle to regular exercise and improves the endurance performance to a greater extent than exercise alone. Thus, 30 adult mice were randomly divided into three groups of 10 mice/group. The control and the exercise (EX) group received an adequate NA diet, while the EX + NA group received a high NA diet. Mice of the EX and the EX + NA group were subjected to a treadmill endurance exercise program five times/week during the experimental period of 42 days. At day 41, endurance performance was greater in the EX + NA group than in the control and the EX group (<i>p</i> < 0.05). Mice of the EX + NA group had a higher type IIA (+60%) and a lower type IIB (−55%) fiber percentage in gastrocnemius (GN) muscle than control mice (<i>p</i> < 0.05), while the type I fiber percentage in GN muscle tended to be increased (+100%) in the EX + NA group compared to the control group (<i>p</i> = 0.051). In the EX + NA group, glycogen concentration (+15%) and mRNA levels of two glycolytic (+70–80%) and two glycogenolytic enzymes (+80–120%) in GN muscle were increased compared to the control group (<i>p</i> < 0.05). In conclusion, feeding a high NA diet induces changes in skeletal muscle fiber composition and improves endurance performance of mice subjected to regular endurance exercise. |
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| language | English |
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| publishDate | 2020-04-01 |
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| series | Metabolites |
| spelling | doaj.art-cc41bfbff19445428f87d69c0c1f5e2a2023-11-19T20:24:20ZengMDPI AGMetabolites2218-19892020-04-0110413810.3390/metabo10040138Nicotinic Acid Improves Endurance Performance of Mice Subjected to Treadmill ExerciseRobert Ringseis0Denise K. Gessner1Anna M. Beer2Yvonne Albrecht3Gaiping Wen4Erika Most5Karsten Krüger6Klaus Eder7Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, GermanyInstitute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, GermanyInstitute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, GermanyInstitute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, GermanyInstitute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, GermanyInstitute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, GermanyDepartment of Exercise Physiology and Sports Therapy, Institute of Sports Science, Justus-Liebig-University Giessen, Kugelberg 62, 35394 Giessen, GermanyInstitute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, GermanyRecently, administration of nicotinic acid (NA) at a pharmacological dose was found to induce a similar change in the muscle´s contractile and metabolic phenotype as observed in response to endurance exercise. Thus, the hypothesis was tested that combined NA administration and endurance exercise promotes the adaptation of muscle to regular exercise and improves the endurance performance to a greater extent than exercise alone. Thus, 30 adult mice were randomly divided into three groups of 10 mice/group. The control and the exercise (EX) group received an adequate NA diet, while the EX + NA group received a high NA diet. Mice of the EX and the EX + NA group were subjected to a treadmill endurance exercise program five times/week during the experimental period of 42 days. At day 41, endurance performance was greater in the EX + NA group than in the control and the EX group (<i>p</i> < 0.05). Mice of the EX + NA group had a higher type IIA (+60%) and a lower type IIB (−55%) fiber percentage in gastrocnemius (GN) muscle than control mice (<i>p</i> < 0.05), while the type I fiber percentage in GN muscle tended to be increased (+100%) in the EX + NA group compared to the control group (<i>p</i> = 0.051). In the EX + NA group, glycogen concentration (+15%) and mRNA levels of two glycolytic (+70–80%) and two glycogenolytic enzymes (+80–120%) in GN muscle were increased compared to the control group (<i>p</i> < 0.05). In conclusion, feeding a high NA diet induces changes in skeletal muscle fiber composition and improves endurance performance of mice subjected to regular endurance exercise.https://www.mdpi.com/2218-1989/10/4/138adaptationenduranceexercisenicotinic acidskeletal muscleunfolded protein response |
| spellingShingle | Robert Ringseis Denise K. Gessner Anna M. Beer Yvonne Albrecht Gaiping Wen Erika Most Karsten Krüger Klaus Eder Nicotinic Acid Improves Endurance Performance of Mice Subjected to Treadmill Exercise Metabolites adaptation endurance exercise nicotinic acid skeletal muscle unfolded protein response |
| title | Nicotinic Acid Improves Endurance Performance of Mice Subjected to Treadmill Exercise |
| title_full | Nicotinic Acid Improves Endurance Performance of Mice Subjected to Treadmill Exercise |
| title_fullStr | Nicotinic Acid Improves Endurance Performance of Mice Subjected to Treadmill Exercise |
| title_full_unstemmed | Nicotinic Acid Improves Endurance Performance of Mice Subjected to Treadmill Exercise |
| title_short | Nicotinic Acid Improves Endurance Performance of Mice Subjected to Treadmill Exercise |
| title_sort | nicotinic acid improves endurance performance of mice subjected to treadmill exercise |
| topic | adaptation endurance exercise nicotinic acid skeletal muscle unfolded protein response |
| url | https://www.mdpi.com/2218-1989/10/4/138 |
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