DNAfusion: an R/Bioconductor package for increased sensitivity of detecting gene fusions in liquid biopsies

DNAfusion: an R/Bioconductor package for increased sensitivity of detecting gene fusions in liquid biopsies

Abstract Background EML4-ALK gene fusions are oncogenic drivers in non-small cell lung cancer (NSCLC), and liquid biopsies containing EML4-ALK fragments can be used to study tumor dynamics using next-generation sequencing (NGS). However, the sensitivity of EML4-ALK detection varies between pipelines...

Full description

Bibliographic Details
Main Authors: Christoffer Trier Maansson, Emma Roger Andersen, Maiken Parm Ulhoi, Peter Meldgaard, Boe Sandahl Sorensen
Format: Article
Language:English
Published: BMC 2023-04-01
Series:BMC Bioinformatics
Subjects:
Gene fusion
EML4-ALK
R/Bioconductor
Non-small cell lung cancer
Next-generation sequencing
Variant call
Online Access:https://doi.org/10.1186/s12859-023-05259-3

Similar Items

Similar Items