Identification of the KIF18A alpha-4 helix as a therapeutic target for chromosomally unstable tumor cells

Identification of the KIF18A alpha-4 helix as a therapeutic target for chromosomally unstable tumor cells

Background: The mitotic kinesin, KIF18A, is required for proliferation of cancer cells that exhibit chromosome instability (CIN), implicating it as a promising target for treatment of a subset of aggressive tumor types. Determining regions of the KIF18A protein to target for inhibition will be impor...

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Bibliographic Details
Main Authors: Katherine L. Schutt, Katelyn A. Queen, Kira Fisher, Olivia Budington, Weifeng Mao, Wei Liu, Xiaohui Gu, Yisong Xiao, Fred Aswad, James Joseph, Jason Stumpff
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
mitosis
kinesin
spindle
KIF18A
chromosome instability
small-molecule inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2024.1328077/full

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