Ubiquitylation as a rheostat for TCR signaling: from targeted approaches towards global profiling.

Ubiquitylation as a rheostat for TCR signaling: from targeted approaches towards global profiling.

AbstractT cell receptor (TCR) signaling must be precisely tuned to limit collateral damage and prevent reactivity to self, while still allowing robust protective immune responses that control pathogen invasion. One process that can be used to promote, modify or terminate TCR signaling is ubiquitylat...

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Bibliographic Details
Main Authors: Paula M Oliver, Claire eOleary, Emma eLewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Immunology
Subjects:
Proteomics
Ubiquitin
Ubiquitin-Protein Ligases
T cell
TCR signaling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00618/full

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