Occult Erythrocytic Membrane Damages Upon Physical and Pharmacological Exposures

The study was undertaken to develop a method for detection of occult damages to erythrocytic membranes exposed to a pulsed electric field, ionizing radiation of various nature, the blood substitute perfluorane, and some chemicals. The experimental results led to the conclusion that calibration elect...

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Main Authors: V. V. Moroz, A. M. Chernysh, M. S. Bogushevich, Ye. K, Kozlova, U. A. Bliznyuk, P. Yu. Alekseyeva, A. P. Kozlov
Format: Article
Language:English
Published: Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia 2006-12-01
Series:Общая реаниматология
Subjects:
Online Access:https://www.reanimatology.com/rmt/article/view/1362
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author V. V. Moroz
A. M. Chernysh
M. S. Bogushevich
Ye. K, Kozlova
U. A. Bliznyuk
P. Yu. Alekseyeva
A. P. Kozlov
author_facet V. V. Moroz
A. M. Chernysh
M. S. Bogushevich
Ye. K, Kozlova
U. A. Bliznyuk
P. Yu. Alekseyeva
A. P. Kozlov
author_sort V. V. Moroz
collection DOAJ
description The study was undertaken to develop a method for detection of occult damages to erythrocytic membranes exposed to a pulsed electric field, ionizing radiation of various nature, the blood substitute perfluorane, and some chemicals. The experimental results led to the conclusion that calibration electroporation was effective in identifying occult erythrocytic membrane damages when perfluorane was administered at different concentrations and when y-radiation was used in small doses (0.5—10 cGy). Non-additivity of the rate constants of a reduction in the suspension count of red blood cells was observed when perfluorane was added or when y-radiation and a pulsed electric field had impact on biological membranes.
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spelling doaj.art-cc43a6924e78400a8f14dd75914102ba2023-03-13T09:32:46ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102006-12-0126556010.15360/1813-9779-2006-6-55-601362Occult Erythrocytic Membrane Damages Upon Physical and Pharmacological ExposuresV. V. Moroz0A. M. Chernysh1M. S. Bogushevich2Ye. K, Kozlova3U. A. Bliznyuk4P. Yu. Alekseyeva5A. P. Kozlov6Research Institute of General Reanimatology, Russian Academy of Medical Sciences, MoscowМосковская медицинская академия им. И. М. СеченоваГУ НИИ общей реаниматологии РАМН, МоскваМосковская медицинская академия им. И. М. СеченоваФизический факультет МГУ им. М. В. ЛомоносоваФизический факультет МГУ им. М. В. ЛомоносоваФизический факультет МГУ им. М. В. ЛомоносоваThe study was undertaken to develop a method for detection of occult damages to erythrocytic membranes exposed to a pulsed electric field, ionizing radiation of various nature, the blood substitute perfluorane, and some chemicals. The experimental results led to the conclusion that calibration electroporation was effective in identifying occult erythrocytic membrane damages when perfluorane was administered at different concentrations and when y-radiation was used in small doses (0.5—10 cGy). Non-additivity of the rate constants of a reduction in the suspension count of red blood cells was observed when perfluorane was added or when y-radiation and a pulsed electric field had impact on biological membranes.https://www.reanimatology.com/rmt/article/view/1362электропорациямембраны эритроцитовперфторану-излучениянаведенный трансмембранный потенциал
spellingShingle V. V. Moroz
A. M. Chernysh
M. S. Bogushevich
Ye. K, Kozlova
U. A. Bliznyuk
P. Yu. Alekseyeva
A. P. Kozlov
Occult Erythrocytic Membrane Damages Upon Physical and Pharmacological Exposures
Общая реаниматология
электропорация
мембраны эритроцитов
перфторан
у-излучения
наведенный трансмембранный потенциал
title Occult Erythrocytic Membrane Damages Upon Physical and Pharmacological Exposures
title_full Occult Erythrocytic Membrane Damages Upon Physical and Pharmacological Exposures
title_fullStr Occult Erythrocytic Membrane Damages Upon Physical and Pharmacological Exposures
title_full_unstemmed Occult Erythrocytic Membrane Damages Upon Physical and Pharmacological Exposures
title_short Occult Erythrocytic Membrane Damages Upon Physical and Pharmacological Exposures
title_sort occult erythrocytic membrane damages upon physical and pharmacological exposures
topic электропорация
мембраны эритроцитов
перфторан
у-излучения
наведенный трансмембранный потенциал
url https://www.reanimatology.com/rmt/article/view/1362
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AT amchernysh occulterythrocyticmembranedamagesuponphysicalandpharmacologicalexposures
AT msbogushevich occulterythrocyticmembranedamagesuponphysicalandpharmacologicalexposures
AT yekkozlova occulterythrocyticmembranedamagesuponphysicalandpharmacologicalexposures
AT uabliznyuk occulterythrocyticmembranedamagesuponphysicalandpharmacologicalexposures
AT pyualekseyeva occulterythrocyticmembranedamagesuponphysicalandpharmacologicalexposures
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