Long‐term anxiety and depression signatures of participants that received esophageal cancer screening: A multicenter population‐based cohort study
Abstract Background Current evidence on the psychological impact of screening and diagnosis of esophageal cancer (EC) is limited and unclear. Methods This multicenter, population‐based, prospective study was conducted in five high‐incidence regions in China from 2017 to 2020. The screened participan...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.5404 |
| _version_ | 1797866867637878784 |
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| author | Juan Zhu Shanrui Ma Ru Chen Shuanghua Xie Zhaorui Liu Zhengkui Liu Wenqiang Wei |
| author_facet | Juan Zhu Shanrui Ma Ru Chen Shuanghua Xie Zhaorui Liu Zhengkui Liu Wenqiang Wei |
| author_sort | Juan Zhu |
| collection | DOAJ |
| description | Abstract Background Current evidence on the psychological impact of screening and diagnosis of esophageal cancer (EC) is limited and unclear. Methods This multicenter, population‐based, prospective study was conducted in five high‐incidence regions in China from 2017 to 2020. The screened participants were diagnosed as healthy, esophagitis, low‐grade intraepithelial neoplasia (LGIN), high‐grade intraepithelial neoplasia (HGIN), or EC based on pathological biopsy. The psychological impact of the screening was assessed by comparing anxiety and depression symptoms at baseline and follow‐up. Results A total of 1973 individuals were ultimately included, with an average follow‐up of 22.2 months. The prevalence of anxiety and depression symptoms in screened population at baseline was 14.3% and 18.4%. The prevalence of anxiety and depression symptoms of screeners at follow‐up declined (all p < 0.001). The anxiety (RR [95% CI]: 0.37 [0.30–0.46]) and depression (0.29 [0.24–0.36]) of screeners weakened over time, but the anxiety and depression symptoms was continuous for patients with HGIN and patients with EC. Compared with the participants classified as normal, the RRs(95% CI) of anxiety and depression symptoms were 2.20 (1.10–4.30) and 2.03 (1.07–3.86) for the patients with HGIN and 2.30 (0.82–6.20) and 3.79 (01.71–8.43) for the patients with EC. Conclusion The anxiety and depression symptoms of screeners weakened over time, except in patients with HGIN and EC, for whom it remained lasting and high. Psychological assistance and interventions are urgently needed for individuals who are ready for screening and for those diagnosed as having HGIN or EC. |
| first_indexed | 2024-04-09T23:31:12Z |
| format | Article |
| id | doaj.art-cc43d313b87f43e2a0181094c8dd38a1 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-09T23:31:12Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-cc43d313b87f43e2a0181094c8dd38a12023-03-21T05:20:41ZengWileyCancer Medicine2045-76342023-03-011256294630610.1002/cam4.5404Long‐term anxiety and depression signatures of participants that received esophageal cancer screening: A multicenter population‐based cohort studyJuan Zhu0Shanrui Ma1Ru Chen2Shuanghua Xie3Zhaorui Liu4Zhengkui Liu5Wenqiang Wei6National Central Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer / Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaNational Central Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer / Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaNational Central Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer / Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaNational Central Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer / Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaKey Laboratory of Mental Health, Ministry of Health (Peking University) Institute of Mental Health, Peking University Beijing ChinaKey Laboratory of Mental Health Institute of Psychology, Chinese Academy of Sciences Beijing ChinaNational Central Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer / Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaAbstract Background Current evidence on the psychological impact of screening and diagnosis of esophageal cancer (EC) is limited and unclear. Methods This multicenter, population‐based, prospective study was conducted in five high‐incidence regions in China from 2017 to 2020. The screened participants were diagnosed as healthy, esophagitis, low‐grade intraepithelial neoplasia (LGIN), high‐grade intraepithelial neoplasia (HGIN), or EC based on pathological biopsy. The psychological impact of the screening was assessed by comparing anxiety and depression symptoms at baseline and follow‐up. Results A total of 1973 individuals were ultimately included, with an average follow‐up of 22.2 months. The prevalence of anxiety and depression symptoms in screened population at baseline was 14.3% and 18.4%. The prevalence of anxiety and depression symptoms of screeners at follow‐up declined (all p < 0.001). The anxiety (RR [95% CI]: 0.37 [0.30–0.46]) and depression (0.29 [0.24–0.36]) of screeners weakened over time, but the anxiety and depression symptoms was continuous for patients with HGIN and patients with EC. Compared with the participants classified as normal, the RRs(95% CI) of anxiety and depression symptoms were 2.20 (1.10–4.30) and 2.03 (1.07–3.86) for the patients with HGIN and 2.30 (0.82–6.20) and 3.79 (01.71–8.43) for the patients with EC. Conclusion The anxiety and depression symptoms of screeners weakened over time, except in patients with HGIN and EC, for whom it remained lasting and high. Psychological assistance and interventions are urgently needed for individuals who are ready for screening and for those diagnosed as having HGIN or EC.https://doi.org/10.1002/cam4.5404anxietycohortdepressionendoscopic screeningesophageal cancerhigh‐grade intraepithelial neoplasia |
| spellingShingle | Juan Zhu Shanrui Ma Ru Chen Shuanghua Xie Zhaorui Liu Zhengkui Liu Wenqiang Wei Long‐term anxiety and depression signatures of participants that received esophageal cancer screening: A multicenter population‐based cohort study Cancer Medicine anxiety cohort depression endoscopic screening esophageal cancer high‐grade intraepithelial neoplasia |
| title | Long‐term anxiety and depression signatures of participants that received esophageal cancer screening: A multicenter population‐based cohort study |
| title_full | Long‐term anxiety and depression signatures of participants that received esophageal cancer screening: A multicenter population‐based cohort study |
| title_fullStr | Long‐term anxiety and depression signatures of participants that received esophageal cancer screening: A multicenter population‐based cohort study |
| title_full_unstemmed | Long‐term anxiety and depression signatures of participants that received esophageal cancer screening: A multicenter population‐based cohort study |
| title_short | Long‐term anxiety and depression signatures of participants that received esophageal cancer screening: A multicenter population‐based cohort study |
| title_sort | long term anxiety and depression signatures of participants that received esophageal cancer screening a multicenter population based cohort study |
| topic | anxiety cohort depression endoscopic screening esophageal cancer high‐grade intraepithelial neoplasia |
| url | https://doi.org/10.1002/cam4.5404 |
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