As Yet Uncultured, or Poorly Culturable Microbes as Sources of Bioactive Agents
In this short review, I am discussing the relatively recent awareness of the role of symbionts in plant, marine and fungal areas. It is now quite obvious that in the marine area, a majority of compounds found are from either as yet unculturable or poorly culturable microbes, and techniques involvin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-11-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01832/full |
| _version_ | 1818560684637552640 |
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| author | David John Newman |
| author_facet | David John Newman |
| author_sort | David John Newman |
| collection | DOAJ |
| description | In this short review, I am discussing the relatively recent awareness of the role of symbionts in plant, marine and fungal areas. It is now quite obvious that in the marine area, a majority of compounds found are from either as yet unculturable or poorly culturable microbes, and techniques involving state of the art genomic analyses and subsequent computerized analyses are required to investigate these interactions. In the plant kingdom evidence is amassing that endophytes (mainly fungal in nature) are heavily involved in secondary metabolite production and that mimicking the microbial interactions of fermentable microbes leads to involvement of previously unrecognized gene clusters (cryptic clusters is one name used), that when activated, produce previously unknown bioactive molecules. |
| first_indexed | 2024-12-14T00:41:26Z |
| format | Article |
| id | doaj.art-cc43ecb9bf0a4e6a8cce09838ea0397f |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-14T00:41:26Z |
| publishDate | 2016-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-cc43ecb9bf0a4e6a8cce09838ea0397f2022-12-21T23:24:22ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2016-11-01710.3389/fmicb.2016.01832219369As Yet Uncultured, or Poorly Culturable Microbes as Sources of Bioactive AgentsDavid John Newman0Newman Consulting LLCIn this short review, I am discussing the relatively recent awareness of the role of symbionts in plant, marine and fungal areas. It is now quite obvious that in the marine area, a majority of compounds found are from either as yet unculturable or poorly culturable microbes, and techniques involving state of the art genomic analyses and subsequent computerized analyses are required to investigate these interactions. In the plant kingdom evidence is amassing that endophytes (mainly fungal in nature) are heavily involved in secondary metabolite production and that mimicking the microbial interactions of fermentable microbes leads to involvement of previously unrecognized gene clusters (cryptic clusters is one name used), that when activated, produce previously unknown bioactive molecules.http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01832/fullEndophytesuncultured microbesmicrobe-microbe interactionsNatural Product Sourcespoor producing microbes |
| spellingShingle | David John Newman As Yet Uncultured, or Poorly Culturable Microbes as Sources of Bioactive Agents Frontiers in Microbiology Endophytes uncultured microbes microbe-microbe interactions Natural Product Sources poor producing microbes |
| title | As Yet Uncultured, or Poorly Culturable Microbes as Sources of Bioactive Agents |
| title_full | As Yet Uncultured, or Poorly Culturable Microbes as Sources of Bioactive Agents |
| title_fullStr | As Yet Uncultured, or Poorly Culturable Microbes as Sources of Bioactive Agents |
| title_full_unstemmed | As Yet Uncultured, or Poorly Culturable Microbes as Sources of Bioactive Agents |
| title_short | As Yet Uncultured, or Poorly Culturable Microbes as Sources of Bioactive Agents |
| title_sort | as yet uncultured or poorly culturable microbes as sources of bioactive agents |
| topic | Endophytes uncultured microbes microbe-microbe interactions Natural Product Sources poor producing microbes |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01832/full |
| work_keys_str_mv | AT davidjohnnewman asyetunculturedorpoorlyculturablemicrobesassourcesofbioactiveagents |