Association of lipoprotein(a) with left ventricular hypertrophy assessed by electrocardiogram in adults: a large cross-sectional study
Background and aimsIncreasing evidence supports a causal relationship between lipoprotein(a) [Lp(a)] and atherosclerotic cardiovascular disease, yet its association with left ventricular hypertrophy (LVH) assessed by electrocardiogram (ECG) remains unknown. The aim of this study was to explore the r...
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Frontiers Media S.A.
2023-11-01
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Series: | Frontiers in Endocrinology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1260050/full |
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author | Xuejiao Yan Jing Gong Zhenwei Wang Fangfang Wang Chunjian Qi |
author_facet | Xuejiao Yan Jing Gong Zhenwei Wang Fangfang Wang Chunjian Qi |
author_sort | Xuejiao Yan |
collection | DOAJ |
description | Background and aimsIncreasing evidence supports a causal relationship between lipoprotein(a) [Lp(a)] and atherosclerotic cardiovascular disease, yet its association with left ventricular hypertrophy (LVH) assessed by electrocardiogram (ECG) remains unknown. The aim of this study was to explore the relationship between Lp(a) and LVH assessed by ECG in general population.Methods and resultsIn this cross-sectional study, we screened 4,052 adults from the participants of the third National Health and Nutrition Examination Survey for analysis. Lp(a) was regarded as an exposure variable. LVH defined by the left ventricular mass index estimated from ECG was considered as an outcome variable. Multivariate logistic regression and restricted cubic spline (RCS) were used to assess the relationship between Lp(a) and LVH. Individuals with LVH had higher Lp(a) compared to individuals without LVH (P< 0.001). In the fully adjusted model, Lp(a) was strongly associated with LVH when as a continuous variable (per 1-unit increment, OR: 1.366, 95% CI: 1.043-1.789, P = 0.024), and higher Lp(a) remained independently associated with a higher risk of LVH when participants were divided into four groups according to quartiles of Lp(a) (Q4 vs Q1, OR: 1.508, 95% CI: 1.185-1.918, P = 0.001). And in subgroup analysis, this association remained significant among participants< 60 years, ≥ 60 years, male, with body mass index< 30 kg/m2, with hypertension and without diabetes (P< 0.05). In addition, we did not observe a nonlinear and threshold effect of Lp(a) with LVH in the RCS analysis (P for nonlinearity = 0.113).ConclusionLp(a) was closely associated with LVH assessed by ECG in general population. |
first_indexed | 2024-03-09T10:45:50Z |
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issn | 1664-2392 |
language | English |
last_indexed | 2024-03-09T10:45:50Z |
publishDate | 2023-11-01 |
publisher | Frontiers Media S.A. |
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series | Frontiers in Endocrinology |
spelling | doaj.art-cc48779b39ee4a299cab8f3ba6bc55c52023-12-01T10:04:35ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-11-011410.3389/fendo.2023.12600501260050Association of lipoprotein(a) with left ventricular hypertrophy assessed by electrocardiogram in adults: a large cross-sectional studyXuejiao Yan0Jing Gong1Zhenwei Wang2Fangfang Wang3Chunjian Qi4Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, ChinaDepartment of Geriatrics, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, ChinaMedical Research Center, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, ChinaBackground and aimsIncreasing evidence supports a causal relationship between lipoprotein(a) [Lp(a)] and atherosclerotic cardiovascular disease, yet its association with left ventricular hypertrophy (LVH) assessed by electrocardiogram (ECG) remains unknown. The aim of this study was to explore the relationship between Lp(a) and LVH assessed by ECG in general population.Methods and resultsIn this cross-sectional study, we screened 4,052 adults from the participants of the third National Health and Nutrition Examination Survey for analysis. Lp(a) was regarded as an exposure variable. LVH defined by the left ventricular mass index estimated from ECG was considered as an outcome variable. Multivariate logistic regression and restricted cubic spline (RCS) were used to assess the relationship between Lp(a) and LVH. Individuals with LVH had higher Lp(a) compared to individuals without LVH (P< 0.001). In the fully adjusted model, Lp(a) was strongly associated with LVH when as a continuous variable (per 1-unit increment, OR: 1.366, 95% CI: 1.043-1.789, P = 0.024), and higher Lp(a) remained independently associated with a higher risk of LVH when participants were divided into four groups according to quartiles of Lp(a) (Q4 vs Q1, OR: 1.508, 95% CI: 1.185-1.918, P = 0.001). And in subgroup analysis, this association remained significant among participants< 60 years, ≥ 60 years, male, with body mass index< 30 kg/m2, with hypertension and without diabetes (P< 0.05). In addition, we did not observe a nonlinear and threshold effect of Lp(a) with LVH in the RCS analysis (P for nonlinearity = 0.113).ConclusionLp(a) was closely associated with LVH assessed by ECG in general population.https://www.frontiersin.org/articles/10.3389/fendo.2023.1260050/fulllipoprotein(a)left ventricular hypertrophyleft ventricular mass indexcardiovascular diseasegeneral population |
spellingShingle | Xuejiao Yan Jing Gong Zhenwei Wang Fangfang Wang Chunjian Qi Association of lipoprotein(a) with left ventricular hypertrophy assessed by electrocardiogram in adults: a large cross-sectional study Frontiers in Endocrinology lipoprotein(a) left ventricular hypertrophy left ventricular mass index cardiovascular disease general population |
title | Association of lipoprotein(a) with left ventricular hypertrophy assessed by electrocardiogram in adults: a large cross-sectional study |
title_full | Association of lipoprotein(a) with left ventricular hypertrophy assessed by electrocardiogram in adults: a large cross-sectional study |
title_fullStr | Association of lipoprotein(a) with left ventricular hypertrophy assessed by electrocardiogram in adults: a large cross-sectional study |
title_full_unstemmed | Association of lipoprotein(a) with left ventricular hypertrophy assessed by electrocardiogram in adults: a large cross-sectional study |
title_short | Association of lipoprotein(a) with left ventricular hypertrophy assessed by electrocardiogram in adults: a large cross-sectional study |
title_sort | association of lipoprotein a with left ventricular hypertrophy assessed by electrocardiogram in adults a large cross sectional study |
topic | lipoprotein(a) left ventricular hypertrophy left ventricular mass index cardiovascular disease general population |
url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1260050/full |
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