Production of Defective Interfering Particles of Influenza A Virus in Parallel Continuous Cultures at Two Residence Times—Insights From qPCR Measurements and Viral Dynamics Modeling

Production of Defective Interfering Particles of Influenza A Virus in Parallel Continuous Cultures at Two Residence Times—Insights From qPCR Measurements and Viral Dynamics Modeling

Defective interfering particles (DIPs) are a natural byproduct of influenza A virus (IAV) replication. DIPs interfere with the propagation and spread of infectious standard virus (STV), reduce virus yields by competing for viral and cellular resources, and induce antiviral responses. These propertie...

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Bibliographic Details
Main Authors: Felipe Tapia, Tanja Laske, Milena A. Wasik, Markus Rammhold, Yvonne Genzel, Udo Reichl
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
influenza A virus
continuous virus production
suspension MDCK cells
defective interfering particles
mathematical model
virus evolution
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00275/full

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