Psoriasis/Psoriatic Arthritis Patients’ Long-term Treatment Patterns and Adherence to Systemic Treatments Monitoring Recommendations
Limited information exists regarding treatment of patients with psoriasis/psoriatic arthritis in primary care. The aim of this study is to assess treatment patterns, adherence, persistence, and compliance in newly diagnosed patients with psoriasis/psoriatic arthritis from 2012 to 2018 in Stockholm,...
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2023-06-01
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| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: | https://medicaljournalssweden.se/actadv/article/view/6505 |
| _version_ | 1797803687623524352 |
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| author | Åsa Krantz Juan Jesus Carrero Yuanhang Yang Lovisa Schalin Josefin Lysell Faizan Mazhar |
| author_facet | Åsa Krantz Juan Jesus Carrero Yuanhang Yang Lovisa Schalin Josefin Lysell Faizan Mazhar |
| author_sort | Åsa Krantz |
| collection | DOAJ |
| description | Limited information exists regarding treatment of patients with psoriasis/psoriatic arthritis in primary care. The aim of this study is to assess treatment patterns, adherence, persistence, and compliance in newly diagnosed patients with psoriasis/psoriatic arthritis from 2012 to 2018 in Stockholm, Sweden. In addition, laboratory monitoring before initiation of treatment and at recommended intervals was quantified for patients prescribed methotrexate or biologics. A total of 51,639 individuals were included, with 39% initiating treatment with topical corticosteroids and < 5% receiving systemic treatment within 6 months post-diagnosis. During a median (interquartile range) follow-up of 7 (4–8) years, 18% of patients received systemic treatments at some point. Overall, 5-year persistence rates were 32%, 45% and 19% for methotrexate, biologics, and other systemic treatments, respectively. Pre-initiation laboratory tests, as recommended by guidelines, were performed in approximately 70% and 62% of methotrexate and biologics users, respectively. Follow-up monitoring at recommended time intervals occurred in 14–20% and 31–33% of patients prescribed methotrexate and biologics, respectively. These findings highlight gaps in the pharmacological care of patients with psoriasis/psoriatic arthritis, including suboptimal adherence/persistence and inadequate laboratory monitoring.
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| first_indexed | 2024-03-13T05:24:39Z |
| format | Article |
| id | doaj.art-cc4ca1b427454d24b4502a1c7fcf24e6 |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-03-13T05:24:39Z |
| publishDate | 2023-06-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-cc4ca1b427454d24b4502a1c7fcf24e62023-06-15T09:09:51ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572023-06-0110310.2340/actadv.v103.6505Psoriasis/Psoriatic Arthritis Patients’ Long-term Treatment Patterns and Adherence to Systemic Treatments Monitoring RecommendationsÅsa Krantz0Juan Jesus Carrero1Yuanhang Yang2Lovisa Schalin3Josefin Lysell4Faizan Mazhar5Dermatology and Venereology Section, Department of Medicine Solna, Karolinska Institutet, Stockholm, SwedenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, SwedenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, SwedenAmgen SwedenDermatology and Venereology Section, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SwedenLimited information exists regarding treatment of patients with psoriasis/psoriatic arthritis in primary care. The aim of this study is to assess treatment patterns, adherence, persistence, and compliance in newly diagnosed patients with psoriasis/psoriatic arthritis from 2012 to 2018 in Stockholm, Sweden. In addition, laboratory monitoring before initiation of treatment and at recommended intervals was quantified for patients prescribed methotrexate or biologics. A total of 51,639 individuals were included, with 39% initiating treatment with topical corticosteroids and < 5% receiving systemic treatment within 6 months post-diagnosis. During a median (interquartile range) follow-up of 7 (4–8) years, 18% of patients received systemic treatments at some point. Overall, 5-year persistence rates were 32%, 45% and 19% for methotrexate, biologics, and other systemic treatments, respectively. Pre-initiation laboratory tests, as recommended by guidelines, were performed in approximately 70% and 62% of methotrexate and biologics users, respectively. Follow-up monitoring at recommended time intervals occurred in 14–20% and 31–33% of patients prescribed methotrexate and biologics, respectively. These findings highlight gaps in the pharmacological care of patients with psoriasis/psoriatic arthritis, including suboptimal adherence/persistence and inadequate laboratory monitoring. https://medicaljournalssweden.se/actadv/article/view/6505guideline concordancemonitoringtreatment patternsAdherencepersistencepsoriasis |
| spellingShingle | Åsa Krantz Juan Jesus Carrero Yuanhang Yang Lovisa Schalin Josefin Lysell Faizan Mazhar Psoriasis/Psoriatic Arthritis Patients’ Long-term Treatment Patterns and Adherence to Systemic Treatments Monitoring Recommendations Acta Dermato-Venereologica guideline concordance monitoring treatment patterns Adherence persistence psoriasis |
| title | Psoriasis/Psoriatic Arthritis Patients’ Long-term Treatment Patterns and Adherence to Systemic Treatments Monitoring Recommendations |
| title_full | Psoriasis/Psoriatic Arthritis Patients’ Long-term Treatment Patterns and Adherence to Systemic Treatments Monitoring Recommendations |
| title_fullStr | Psoriasis/Psoriatic Arthritis Patients’ Long-term Treatment Patterns and Adherence to Systemic Treatments Monitoring Recommendations |
| title_full_unstemmed | Psoriasis/Psoriatic Arthritis Patients’ Long-term Treatment Patterns and Adherence to Systemic Treatments Monitoring Recommendations |
| title_short | Psoriasis/Psoriatic Arthritis Patients’ Long-term Treatment Patterns and Adherence to Systemic Treatments Monitoring Recommendations |
| title_sort | psoriasis psoriatic arthritis patients long term treatment patterns and adherence to systemic treatments monitoring recommendations |
| topic | guideline concordance monitoring treatment patterns Adherence persistence psoriasis |
| url | https://medicaljournalssweden.se/actadv/article/view/6505 |
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