Effects of growth hormone plus gonadotropins on controlled ovarian stimulation in infertile women of advanced age, poor responders, and previous in vitro fertilization failure patients
Objective: To investigate the effects of growth hormone (GH) cotreatment in ovarian stimulation in infertile women of advanced age, poor responders, and patients with one or more previous IVF treatment failures. Materials and methods: We conducted a retrospective observational study of 436 patients...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-12-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455917302577 |
| _version_ | 1818277462100934656 |
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| author | Yao-Kai Ho Tsung-Hsien Lee Chun-I. Lee En-Hui Cheng Chun-Chia Huang Lii-Shung Huang Maw-Sheng Lee |
| author_facet | Yao-Kai Ho Tsung-Hsien Lee Chun-I. Lee En-Hui Cheng Chun-Chia Huang Lii-Shung Huang Maw-Sheng Lee |
| author_sort | Yao-Kai Ho |
| collection | DOAJ |
| description | Objective: To investigate the effects of growth hormone (GH) cotreatment in ovarian stimulation in infertile women of advanced age, poor responders, and patients with one or more previous IVF treatment failures.
Materials and methods: We conducted a retrospective observational study of 436 patients undergoing GH cotreatment in ovarian stimulation. The first arm included 134 infertile women of advanced age. The second arm included 236 patients with one or more IVF previous treatment failures, and the third arm included 66 younger poor responders. Main outcome measures were the number of oocytes and embryos, quality of embryos, and implantation and pregnancy rates.
Results: In infertile women of advanced age, GH plus ovarian stimulation yielded no statistical differences in the numbers of oocytes and embryos, quality of embryo, and rates of implantation and pregnancy. In the second arm, the mature oocyte number (8.2 vs. 6.8), implantation rate (16.1% vs. 0%), and pregnancy rate (33.9% vs. 0%) in the GH cotreatment group differed significantly from those in the control group; the rate of good-quality embryos in the GH cotreatment group improved from 35.5% ± 31.1%–41.4% ± 30.6% in this arm. Similar results were observed in the third arm; in this arm, the clinical pregnancy rate was 30.3% in the GH cotreatment group and 6.1% in the control group.
Conclusion: No significant differences were observed in infertile women of advanced age, which may be due to the low GH dose. The GH adjuvant therapy for patients with one or more previous IVF treatment failures and for poor responders significantly improved the oocyte and embryo numbers as well as implantation and pregnancy rates. |
| first_indexed | 2024-12-12T23:01:55Z |
| format | Article |
| id | doaj.art-cc4e8195c01b44388987133ce9c9e9e4 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-12T23:01:55Z |
| publishDate | 2017-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-cc4e8195c01b44388987133ce9c9e9e42022-12-22T00:08:48ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592017-12-0156680681010.1016/j.tjog.2017.10.018Effects of growth hormone plus gonadotropins on controlled ovarian stimulation in infertile women of advanced age, poor responders, and previous in vitro fertilization failure patientsYao-Kai Ho0Tsung-Hsien Lee1Chun-I. Lee2En-Hui Cheng3Chun-Chia Huang4Lii-Shung Huang5Maw-Sheng Lee6Institute of Medicine, Chung Shan Medial University, Taichung, Taiwan, ROCInstitute of Medicine, Chung Shan Medial University, Taichung, Taiwan, ROCInstitute of Medicine, Chung Shan Medial University, Taichung, Taiwan, ROCGenetic Diagnosis Laboratory, Lee Women's Hospital, Taichung, Taiwan, ROCDivision of Infertility Clinic, Lee Women's Hospital, Taichung, Taiwan, ROCNursing Department, Lee Women's Hospital, Taichung, Taiwan, ROCInstitute of Medicine, Chung Shan Medial University, Taichung, Taiwan, ROCObjective: To investigate the effects of growth hormone (GH) cotreatment in ovarian stimulation in infertile women of advanced age, poor responders, and patients with one or more previous IVF treatment failures. Materials and methods: We conducted a retrospective observational study of 436 patients undergoing GH cotreatment in ovarian stimulation. The first arm included 134 infertile women of advanced age. The second arm included 236 patients with one or more IVF previous treatment failures, and the third arm included 66 younger poor responders. Main outcome measures were the number of oocytes and embryos, quality of embryos, and implantation and pregnancy rates. Results: In infertile women of advanced age, GH plus ovarian stimulation yielded no statistical differences in the numbers of oocytes and embryos, quality of embryo, and rates of implantation and pregnancy. In the second arm, the mature oocyte number (8.2 vs. 6.8), implantation rate (16.1% vs. 0%), and pregnancy rate (33.9% vs. 0%) in the GH cotreatment group differed significantly from those in the control group; the rate of good-quality embryos in the GH cotreatment group improved from 35.5% ± 31.1%–41.4% ± 30.6% in this arm. Similar results were observed in the third arm; in this arm, the clinical pregnancy rate was 30.3% in the GH cotreatment group and 6.1% in the control group. Conclusion: No significant differences were observed in infertile women of advanced age, which may be due to the low GH dose. The GH adjuvant therapy for patients with one or more previous IVF treatment failures and for poor responders significantly improved the oocyte and embryo numbers as well as implantation and pregnancy rates.http://www.sciencedirect.com/science/article/pii/S1028455917302577Infertile women of advanced ageGrowth hormoneIn vitro fertilization failurePoor ovarian response |
| spellingShingle | Yao-Kai Ho Tsung-Hsien Lee Chun-I. Lee En-Hui Cheng Chun-Chia Huang Lii-Shung Huang Maw-Sheng Lee Effects of growth hormone plus gonadotropins on controlled ovarian stimulation in infertile women of advanced age, poor responders, and previous in vitro fertilization failure patients Taiwanese Journal of Obstetrics & Gynecology Infertile women of advanced age Growth hormone In vitro fertilization failure Poor ovarian response |
| title | Effects of growth hormone plus gonadotropins on controlled ovarian stimulation in infertile women of advanced age, poor responders, and previous in vitro fertilization failure patients |
| title_full | Effects of growth hormone plus gonadotropins on controlled ovarian stimulation in infertile women of advanced age, poor responders, and previous in vitro fertilization failure patients |
| title_fullStr | Effects of growth hormone plus gonadotropins on controlled ovarian stimulation in infertile women of advanced age, poor responders, and previous in vitro fertilization failure patients |
| title_full_unstemmed | Effects of growth hormone plus gonadotropins on controlled ovarian stimulation in infertile women of advanced age, poor responders, and previous in vitro fertilization failure patients |
| title_short | Effects of growth hormone plus gonadotropins on controlled ovarian stimulation in infertile women of advanced age, poor responders, and previous in vitro fertilization failure patients |
| title_sort | effects of growth hormone plus gonadotropins on controlled ovarian stimulation in infertile women of advanced age poor responders and previous in vitro fertilization failure patients |
| topic | Infertile women of advanced age Growth hormone In vitro fertilization failure Poor ovarian response |
| url | http://www.sciencedirect.com/science/article/pii/S1028455917302577 |
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