Phosphoinositide 3-Kinase P110δ-Signaling Is Critical for Microbiota-Activated IL-10 Production by B Cells that Regulate Intestinal Inflammation

Phosphoinositide 3-Kinase P110δ-Signaling Is Critical for Microbiota-Activated IL-10 Production by B Cells that Regulate Intestinal Inflammation

The phosphoinositide 3-kinase catalytic subunit p110δ (PI3Kδ) gene maps to a human inflammatory bowel diseases (IBD) susceptibility locus, and genetic deletion of PI3Kδ signaling causes spontaneous colitis in mice. However, little is known regarding the role of PI3K&#9...

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Bibliographic Details
Main Authors: Akihiko Oka, Yoshiyuki Mishima, Bo Liu, Jeremy W. Herzog, Erin C. Steinbach, Taku Kobayashi, Scott E. Plevy, R. Balfour Sartor
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
PI3Kδ
inflammatory bowel diseases
regulatory B cells
IL-10
residential microbiota
Online Access:https://www.mdpi.com/2073-4409/8/10/1121

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https://www.mdpi.com/2073-4409/8/10/1121

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