Polyphenolic compounds of litchi leaf augment kidney and heart functions in 2K1C rats
The study aimed to investigate the nephroprotective and cardioprotective effects of ethanol extract of litchi leaf (LI) in two-kidney-one-clip (2K1C) rat model. HPLC analysis revealed the presence of several polyphenolic antioxidants in LI. Correspondingly, LI at 50–200 mg/kg reduced the level of ox...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619305869 |
| _version_ | 1818617873841520640 |
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| author | Fariha Mamun Md. Mizanur Rahman Mushfera Zamila Nusrat Subhan Hemayet Hossain S.M. Raquibul Hasan Md Ashraful Alam Md. Areeful Haque |
| author_facet | Fariha Mamun Md. Mizanur Rahman Mushfera Zamila Nusrat Subhan Hemayet Hossain S.M. Raquibul Hasan Md Ashraful Alam Md. Areeful Haque |
| author_sort | Fariha Mamun |
| collection | DOAJ |
| description | The study aimed to investigate the nephroprotective and cardioprotective effects of ethanol extract of litchi leaf (LI) in two-kidney-one-clip (2K1C) rat model. HPLC analysis revealed the presence of several polyphenolic antioxidants in LI. Correspondingly, LI at 50–200 mg/kg reduced the level of oxidative stress markers (MDA, APOP, NO) and improved level of endogenous antioxidant enzymes (CAT, SOD) in 2K1C rats. Besides, LI caused significant improvements in kidney and heart functions in 2K1C rats by reducing the plasma level of uric acid and creatinine as well as CK-MB. Consistent with the biochemical findings, histopathological data further confirmed that LI is effective in decreasing heart and kidney injuries, oxidative stress and inflammation which ensued in 2K1C rats. Collectively, the outcomes suggest that the LI enriched in polyphenolic antioxidants may provide the protection against excessive oxidative stress, inflammation and tissue injury, thereby improving the kidney and heart function in 2K1C rats. |
| first_indexed | 2024-12-16T17:12:37Z |
| format | Article |
| id | doaj.art-cc51ebf63d314de386d9456e116ae47b |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-16T17:12:37Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-cc51ebf63d314de386d9456e116ae47b2022-12-21T22:23:23ZengElsevierJournal of Functional Foods1756-46462020-01-0164103662Polyphenolic compounds of litchi leaf augment kidney and heart functions in 2K1C ratsFariha Mamun0Md. Mizanur Rahman1Mushfera Zamila2Nusrat Subhan3Hemayet Hossain4S.M. Raquibul Hasan5Md Ashraful Alam6Md. Areeful Haque7Department of Pharmaceutical Sciences, North South University, BangladeshDepartment of Pharmaceutical Sciences, North South University, BangladeshDepartment of Pharmaceutical Sciences, North South University, BangladeshDepartment of Pharmaceutical Sciences, North South University, BangladeshBCSIR Laboratories, Bangladesh Council of Scientific and Industrial Research, Dhaka, BangladeshDepartment of Pharmaceutical Sciences, Mercer University, 3001 Mercer University Drive, Suite 114, Atlanta, GA 30341, United StatesDepartment of Pharmaceutical Sciences, North South University, Bangladesh; Corresponding authors at: Department of Pharmaceutical Sciences, North South University, Bangladesh (M.A. Alam). Department of Pharmacy, International Islamic University Chittagong, Chittagong-4318, Bangladesh (M.A. Haque).Department of Pharmacy, International Islamic University Chittagong, Chittagong-4318, Bangladesh; Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia; Corresponding authors at: Department of Pharmaceutical Sciences, North South University, Bangladesh (M.A. Alam). Department of Pharmacy, International Islamic University Chittagong, Chittagong-4318, Bangladesh (M.A. Haque).The study aimed to investigate the nephroprotective and cardioprotective effects of ethanol extract of litchi leaf (LI) in two-kidney-one-clip (2K1C) rat model. HPLC analysis revealed the presence of several polyphenolic antioxidants in LI. Correspondingly, LI at 50–200 mg/kg reduced the level of oxidative stress markers (MDA, APOP, NO) and improved level of endogenous antioxidant enzymes (CAT, SOD) in 2K1C rats. Besides, LI caused significant improvements in kidney and heart functions in 2K1C rats by reducing the plasma level of uric acid and creatinine as well as CK-MB. Consistent with the biochemical findings, histopathological data further confirmed that LI is effective in decreasing heart and kidney injuries, oxidative stress and inflammation which ensued in 2K1C rats. Collectively, the outcomes suggest that the LI enriched in polyphenolic antioxidants may provide the protection against excessive oxidative stress, inflammation and tissue injury, thereby improving the kidney and heart function in 2K1C rats.http://www.sciencedirect.com/science/article/pii/S1756464619305869Polyphenolic antioxidantsLitchi chinensis Sonn.Renal artery stenosisCK-MBCardioprotective effect |
| spellingShingle | Fariha Mamun Md. Mizanur Rahman Mushfera Zamila Nusrat Subhan Hemayet Hossain S.M. Raquibul Hasan Md Ashraful Alam Md. Areeful Haque Polyphenolic compounds of litchi leaf augment kidney and heart functions in 2K1C rats Journal of Functional Foods Polyphenolic antioxidants Litchi chinensis Sonn. Renal artery stenosis CK-MB Cardioprotective effect |
| title | Polyphenolic compounds of litchi leaf augment kidney and heart functions in 2K1C rats |
| title_full | Polyphenolic compounds of litchi leaf augment kidney and heart functions in 2K1C rats |
| title_fullStr | Polyphenolic compounds of litchi leaf augment kidney and heart functions in 2K1C rats |
| title_full_unstemmed | Polyphenolic compounds of litchi leaf augment kidney and heart functions in 2K1C rats |
| title_short | Polyphenolic compounds of litchi leaf augment kidney and heart functions in 2K1C rats |
| title_sort | polyphenolic compounds of litchi leaf augment kidney and heart functions in 2k1c rats |
| topic | Polyphenolic antioxidants Litchi chinensis Sonn. Renal artery stenosis CK-MB Cardioprotective effect |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619305869 |
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